Am J Dis Child
 1986
DOI: 10.1001/archpedi.1986.02140250078039
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Elevated Serum Calcium and Osteocalcin Levels From Calcitriol in Preterm Infants

Winston Koo1
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Cited by 20 publications

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“…An interventional study found that preterm infants showed no calcemic response to short courses of supraphysiological doses of calcitriol (0.1-3.0 g/kg), which suggests that the preterm intestines are refractory to calcitriol (708). For perspective, the adult requirement in hypoparathyroidism is typically a total daily dose of 0.25-1.0 g. A second interventional study used 4.0 g/kg of calcitriol administered intravenously for three consecutive days and found a significant increase in serum calcium (325). However, that effect was not the result of an alteration in intestinal calcium absorption but likely reflected an increase in bone resorption: oral intake was minimal, osteocalcin increased significantly, and urine calcium/ creatinine ratio did not change (325).…”
Section: Human Datamentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…An interventional study found that preterm infants showed no calcemic response to short courses of supraphysiological doses of calcitriol (0.1-3.0 g/kg), which suggests that the preterm intestines are refractory to calcitriol (708). For perspective, the adult requirement in hypoparathyroidism is typically a total daily dose of 0.25-1.0 g. A second interventional study used 4.0 g/kg of calcitriol administered intravenously for three consecutive days and found a significant increase in serum calcium (325). However, that effect was not the result of an alteration in intestinal calcium absorption but likely reflected an increase in bone resorption: oral intake was minimal, osteocalcin increased significantly, and urine calcium/ creatinine ratio did not change (325).…”
Section: Human Datamentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…an end-organ resistance to the physiologic effect of the most biologically active vitamin D metabolite, 1,25 dihydroxyvitamin D [1,25(OHhD) (2,3), which theoretically may result in a greater vitamin D requirement in these infants .…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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