Archives of Dermatology
 2000
DOI: 10.1001/archderm.136.1.125
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Elevated RANTES Levels in Plasma or Skin and Decreased Plasma IL-10 Levels in Subsets of Patients With Severe Atopic Dermatitis

Y Niwa1
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Cited by 39 publications

(19 citation statements)
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“…Thorough understanding of the effect of IL-10 will help in the interpretation of the pathogenesis of AD. As noted by Niwa [23]; plasma levels of IL-10 seem to correlate inversely with the severity of AD. However, increased production of IL-10 has been demonstrated by other studies [21, 24].…”
Section: Results
mentioning
confidence: 60%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Thorough understanding of the effect of IL-10 will help in the interpretation of the pathogenesis of AD. As noted by Niwa [23]; plasma levels of IL-10 seem to correlate inversely with the severity of AD. However, increased production of IL-10 has been demonstrated by other studies [21, 24].…”
Section: Results
mentioning
confidence: 60%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…An inverse relationship between plasma IL-10 levels and AD severity was reported both by Niwa and colleagues and by Seneviratne et al (8,9). The latter group demonstrated decreased IL-10 + CD4 + T cells in severely symptomatic vs. mildly affected individuals.…”
Section: Discussion
mentioning
confidence: 58%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…These results suggest that atopic individuals have an intrinsic inability to upregulate DC-derived IL-10 production ( 2 ). In line with this, several studies reported diminished antigen-induced, peripheral blood mononuclear cell (PBMC)-derived IL-10 production in children ( 58 , 59 ) and adults ( 31 , 60 , 61 ) with atopic disorders (AR, asthma, or atopic dermatitis).…”
Section: Introduction
mentioning
confidence: 68%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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