Elevated plasma histamine levels in systemic sclerosis (scleroderma)

Falanga, Vincent

doi:10.1001/archderm.126.3.336

Cited by 14 publications

(4 citation statements)

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“…There was also increased MC degranulation in early but not late disease, and also in currently healthy skin, suggesting that increases in MC numbers and degranulation precede clinically apparent dermal fibrosis. Falanga et al reported raised histamine levels in the plasma of patients with systemic sclerosis providing further evidence of MC activation in this disease.…”

Section: Mast Cells In Human Systemic Sclerosismentioning

confidence: 86%

The controversial role of mast cells in fibrosis

Bradding

Pejler

2018

Immunological Reviews

113

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Fibrosis is a medical condition characterized by an excessive deposition of extracellular matrix compounds such as collagen in tissues. Fibrotic lesions are present in many diseases and can affect all organs. The excessive extracellular matrix accumulation in these conditions can often have serious consequences and in many cases be life-threatening. A typical event seen in many fibrotic conditions is a profound accumulation of mast cells (MCs), suggesting that these cells can contribute to the pathology. Indeed, there is now substantialv evidence pointing to an important role of MCs in fibrotic disease. However, investigations from various clinical settings and different animal models have arrived at partly contradictory conclusions as to how MCs affect fibrosis, with many studies suggesting a detrimental role of MCs whereas others suggest that MCs can be protective. Here, we review the current knowledge of how MCs can affect fibrosis.

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Section: Mast Cells In Human Systemic Sclerosismentioning

confidence: 86%

The controversial role of mast cells in fibrosis

Bradding

Pejler

2018

Immunological Reviews

113

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“…Abnormal metabolic stimulation of the formation of extracellular matrix in the skin causes keloid or hypertrophic scars in which the over-activated chronic inflammatory process is involved 8,9. The signaling pathway of abnormal fibrosis caused by cellular proliferation and inflammation is now being studied from a different point of view, and recent reports have shown some proof that TLR activation can increase inflammatory cytokines in fibroblasts 7…”

Section: Discussionmentioning

confidence: 99%

The Expression of Toll-Like Receptors (TLRs) in Cultured Human Skin Fibroblast is Modulated by Histamine

et al. 2012

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Fibroblasts are responsible for the synthesis and degradation of various connective tissue components and soluble mediators of extracellular matrix metabolism. Few studies have been conducted concerning the expression of toll-like receptors (TLRs) in fibroblasts until now. This study aimed first to determine the quantitative expression of TLRs 1 to 10 in human skin fibroblasts and secondarily to explore any influence of expression by histamine, which is a well-known factor engaged in dermal inflammation. It was found that all 10 TLRs were expressed in fibroblasts. Interestingly, the expression of TLRs 4, 5, and 10 was increased after 2 and 6 hours of histamine treatment during culture. However, the expression of TLRs 2, 3, 6, 7, 8, and 9 was decreased after 6 hours of histamine treatment. Among the TLRs with a decreasing expression pattern, TLRs 7 and 8 showed a persistent tendency to decrease. All of these changes in TLR expression with histamine treatment were antagonized by treatment with diphenhydramine, a well-known antihistamine. Thus, these results suggest a role of histamine in the early phase of the dermal inflammatory reaction mediated by TLRs.

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“…It is a collagen vascular disease leading to induration of the skin caused by excessive collagen deposition in the dermis and subcutis, with only small amounts of mucin, if present at all. 9 The typical histologic finding in scleredema is a thickening of the reticular dermis with large collagen bundles that extend into the subcutis. 16 An important entity in the differential diagnosis of scleromyxedema in human medicine is nephrogenic fibrosing dermatopathy, which may develop with chronic renal disease and lead to skin lesions histologically identical to those of scleromyxedema.…”

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confidence: 99%

Scleromyxedema-like Syndrome With Systemic Involvement in a Cat

et al. 2010

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Scleromyxedema-the generalized form of lichen myxedematosus, a primary mucinosis-is a rare disease in human patients. It is characterized by dermal mucin deposits, increased numbers of fibroblasts, and variable fibrosis in the absence of thyroid disease. It is accompanied in 80% of cases by a monoclonal gammopathy. To date, scleromyxedema with systemic involvement has not been documented in domestic animals. This is the first report of a scleromyxedema-like syndrome in a cat, which had a substantial deposition of mucin in the dermis of the head and paws with a mild gammaglobulinemia of 2.25 g/dl (reference range, 1.39-2.22 g/dl). At necropsy, multiple nodules of connective tissue intermingled with mucin deposits were conspicuous on the surface of thoracic and abdominal organs. Such severe systemic accumulations of mucin have not been reported in human or veterinary medicine.

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Elevated plasma histamine levels in systemic sclerosis (scleroderma)

Cited by 14 publications

References 0 publications

The controversial role of mast cells in fibrosis

The controversial role of mast cells in fibrosis

The Expression of Toll-Like Receptors (TLRs) in Cultured Human Skin Fibroblast is Modulated by Histamine

Scleromyxedema-like Syndrome With Systemic Involvement in a Cat

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