Elevated Monoamine Oxidase-A Distribution Volume in Borderline Personality Disorder Is Associated With Severity Across Mood Symptoms, Suicidality, and Cognition

Kolla, Nathan J.; Chiuccariello, Lina; Wilson, Alan A.; Houle, Sylvain; Links, Paul S.; Bagby, R. Michael; McMain, Shelley; Kellow, Charis; Patel, Jalpa; Rekkas, P. Vivien; Pasricha, Suvercha; Meyer, Jeffrey H.

doi:10.1016/j.biopsych.2014.11.024

Cited by 35 publications

(23 citation statements)

References 77 publications

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“…Although sources of oxidative stress outside the brain cannot be ruled out, brain metabolism accounts for 20% of the body's oxygen (O 2 ) budget, out of proportion to its mass. This is because the principal sources of oxidative species are neural activity itself (Halliwell, 1992), intracellular energy cycling (Cobley, Fiorello, & Bailey, 2018), nitrosamine signaling between neurons (Finnell & Wood, 2018), and catabolism of monoamine neuromodulators such as serotonin and norepinephrine by the mitochondrial enzyme monoamine oxidase A (MAO-A; Kolla et al, 2016). Increased neural signaling during periods of psychological stress would thus be expected to increase the oxidation burden.…”

Section: Discussionmentioning

confidence: 99%

“…Increased neural signaling during periods of psychological stress would thus be expected to increase the oxidation burden. Interestingly, elevated MAO-A activity is increased in the prefrontal cortex of individuals with BPD (Kolla et al, 2016). Upregulation of MAO-A activity would be expected to generate oxidative species through the oxidation of monoamine neurotransmitters and could increase circulating 8-OH-DG levels.…”

Section: Discussionmentioning

confidence: 99%

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Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Lee

Gozal

Coccaro

et al. 2020

Journal of Personality Disorders

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The authors hypothesized that personality disorders characterized by interpersonal hypersensitivity would be associated with an elevated concentration of 8-hydroxy-2'-deoxyguanosine (8-OH-DG), the oxidized form of guanine, and a biomarker of oxidative stress burden. One hundred ninety-five male and female adults underwent semistructured diagnostic interviews, completed questionnaire measures of social cognition and emotional attribution, and had blood drawn for determination of plasma 8-OH-DG. A hierarchical linear regression model revealed that narcissistic and borderline personality disorders predicted 8-OH-DG level independently of the effects of age, gender, recent alcohol and cigarette use, current major depression, and posttraumatic stress disorder. In all subjects, 8-OH-DG level was also correlated with the number of borderline personality disorder symptoms present. Narcissistic and borderline personality disorders predicted oxidative stress burden independently of potentially confounding factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Lee

Gozal

Coccaro

et al. 2020

Journal of Personality Disorders

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“…To address this issue and increase the robustness of the analyses, BPD and ASPD subjects were combined into a single group. Although ASPD and BPD have been conceptualized as different aspects of the same disorder manifested in a gender‐specific manner , it is now widely accepted that the two conditions are separate disorders , with growing research to suggest that ASPD and BPD have distinct neurobiological underpinnings . While externalized aggression is a DSM‐5 diagnostic criterion for both disorders and several laboratories investigating aggression include mixed samples of ASPD and BPD subjects , it is likely that there are subtle differences in the personality characteristics of ASPD and BPD underlying high trait physical aggression.…”

Section: Discussionmentioning

confidence: 99%

Trait Anger, Physical Aggression, and Violent Offending in Antisocial and Borderline Personality Disorders

Kolla

Meyer

Bagby

et al. 2016

Journal of Forensic Sciences

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Antisocial personality disorder (ASPD) and borderline personality disorder (BPD) are common conditions in forensic settings that present high rates of violence. Personality traits related to the five-factor model personality domains of neuroticism and agreeableness have shown a relationship with physical aggression in nonclinical and general psychiatric samples. The aim of the present investigation was to examine the association of these personality traits with violence and aggression in ASPD and BPD. Results revealed that trait anger/hostility predicted self-reported physical aggression in 47 ASPD and BPD subjects (β = 0.5, p = 0.03) and number of violent convictions in a subsample of the ASPD participants (β = 0.2, p = 0.009). These preliminary results suggest that high anger and hostility are associated with physical aggression in BPD and ASPD. Application of validated, self-report personality measures could provide useful and easily accessible information to supplement clinical risk assessment of violence in these conditions.

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“…A few studies that investigated neurotransmitter systems other than 5-HT implicated the ACC in relation to SI. For example, a positive association was shown between SI and ACC monoamine oxidase-A density in adults with BPD [88]. A relation between SI and increased ACC neuroinflammation (as assessed by translocator protein (TSPO) availability) was reported in adults with MDD [89].…”

Section: Anterior Cingulate Cortexmentioning

confidence: 98%

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Elevated Monoamine Oxidase-A Distribution Volume in Borderline Personality Disorder Is Associated With Severity Across Mood Symptoms, Suicidality, and Cognition

Abstract: These results suggest that elevated MAO-A VT is associated with multiple indicators of BPD severity, including BPD symptomatology, mood symptoms, suicidality, and neurocognitive impairment.

Cited by 35 publications

References 77 publications

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

Trait Anger, Physical Aggression, and Violent Offending in Antisocial and Borderline Personality Disorders

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

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