Elevated Immune Response Among Children 4 Years of Age With Pronounced Local Adverse Events After the Fifth Diphtheria, Tetanus, Acellular Pertussis Vaccination

Abstract

Children with pronounced local reactions show higher humoral and cellular immune responses. Acellular vaccines are known to skew toward more Th2 responses. The pronounced local AEs may be associated with more Th2 skewing after the fifth DTaP-IPV vaccination, but other biologic factors may also impact the occurrence of these pronounced local reactions.

Safety Surveillance of Diphtheria and Tetanus Toxoids and Acellular Pertussis (DTaP) Vaccines

“…Increased local reactogenicity after a booster of DTaP-containing vaccines has been well documented, and it has been potentially attributed to cellular and humoral immune responses to the vaccine [46,47]. We also found higher disproportional reporting mainly for other labeled events, ‘intussusception,’ ‘haematochezia’ and other related gastrointestinal conditions that may have been related to the concomitant administration of rotavirus vaccines, for which the associations with intussusception and/or hematochezia have been well documented [47–50]. Through our clinical review of a sample of serious DTaP reports, we also noted that intussusception was the most common diagnosis among gastrointestinal events, and in all these selected reports, rotavirus vaccines were co-administered with a DTaP vaccine.…”

Robust Humoral and Cellular Immune Responses to Pertussis in Adults After a First Acellular Booster Vaccination

“…For T-cell responses, PBMCs were stimulated for 5 days with PT (heat inactivated), FHA, Prn, Dd, or Td after which supernatants were collected and stored at −80°C ( 26 ). Unstimulated and pokeweed mitogen-stimulated cells served as negative and positive controls, respectively.…”