Elevated IL‐17A and IL‐22 regulate expression of inducible CD38 and Zap‐70 in chronic lymphocytic leukemia

Kouzegaran, Samaneh; Siroosbakht, Soheila; Farsad, Bahram Fariborz; Rezakhaniha, Bijan; Dormanesh, Banafshe; Behnod, Vahid; Tanha, Amir Saber

doi:10.1002/cyto.b.21487

Cited by 12 publications

(15 citation statements)

References 31 publications

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“…High IL-22 concentrations and the elevated expression of CD38 may be implicated in the synergetic stimulation of genes involved in proliferation and programmed cell death. Elevated levels are connected with poor outcome in B-CLL patients [182], and it has been reported as a prognostic biomarker in cancers [183,184].…”

Section: Effects Of Cytokines On the Onset Progression And Complicamentioning

confidence: 99%

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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B-cell chronic lymphocytic leukemia (B-CLL) is the main cause of mortality among hematologic diseases in Western nations. B-CLL is correlated with an intense alteration of the immune system. The altered functions of innate immune elements and adaptive immune factors are interconnected in B-CLL and are decisive for its onset, evolution, and therapeutic response. Modifications in the cytokine balance could support the growth of the leukemic clone via a modulation of cellular proliferation and apoptosis, as some cytokines have been reported to be able to affect the life of B-CLL cells in vivo. In this review, we will examine the role played by cytokines in the cellular dynamics of B-CLL patients, interpret the contradictions sometimes present in the literature regarding their action, and evaluate the possibility of manipulating their production in order to intervene in the natural history of the disease.

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Section: Effects Of Cytokines On the Onset Progression And Complicamentioning

confidence: 99%

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Allegra

Musolino

Tonacci

et al. 2020

Cancers

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“…It has been reported that the PBMCs of CLL patients had higher levels of IL-17A and IL-22 mRNA expressions compared with healthy subjects. Moreover, the IL-17A and IL-22 plasma levels were significantly higher in CLL patients compared with control group among Iranians [43]. IL-1β is a pro-inflammatory cytokine that promotes the B cells and lymphocytes proliferation.…”

Section: Inflammatory Factors and Immune Responsementioning

confidence: 90%

Genetics of blood malignancies among Iranian population: an overview

et al. 2020

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Background Blood malignancies are among the leading causes of cancer related deaths in the world. Different environmental and genetic risk factors are involved in progression of blood malignancies. It has been shown that the lifestyle changes have affected the epidemiological patterns of these malignancies. Hematologic cancers are the 5th common cancer among Iranian population. It has been observed that there is a rising trend of blood malignancies incidences during the recent decades. Therefore, it is required to design novel diagnostic methods for the early detection of such malignancies in this population. Main body In present review we have summarized all of the significant genes which have been reported among Iranian patients with blood malignancies. The reported genes were categorized based on their cell and molecular functions to clarify the molecular biology and genetics of blood malignancies among Iranian patients. Conclusion It was observed that the epigenetic and immune response factors were the most frequent molecular processes associated with progression of blood malignancies among Iranian population. This review paves the way of introducing a population based panel of genetic markers for the early detection of blood malignancies in this population.

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“…Endocan overexpression at either messenger ribonucleic acid (mRNA) or protein level have been observed in pituitary adenoma (9,10), gastric cancer (11), bladder cancer (12), non-small cell lung cancer (13), colorectal cancer (14), glioblastoma (15), renal cell carcinoma (16), hepatocellular carcinoma (17), squamous cell carcinoma of head and neck (18,19), pancreatic neuroendocrine tumor (20) and ovarian cancer (21). It is generally accepted that Endocan overexpression is associated with aggressive progression and poor outcomes of tumors (22).…”

Section: Introductionmentioning

confidence: 99%

Significance of Endocan Expression in Various Types of Epithelial Ovarian Tumors

et al. 2022

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Scan to discover onlineBackground & Objective: Ovarian cancer is associated with the highest mortality rate among gynecologic malignancies. Despite new therapeutic strategies, ovarian cancer still has a high risk of metastasis and mortality. Endocan is a newly identified endothelial cell activation marker, which is responsible for angiogenesis, tumor invasion, and aggressive behavior of tumors. The aim of this study was to assess Endocan expression in different types of ovarian tumors and to identify its relationship with clinicopathologic characteristics of ovarian tumors. Methods:This cross-sectional study was conducted on 183 tissue samples, including benign, borderline, and malignant ovarian tumors collected from the University Kebangsaan Malaysia Medical Center archive of Pathology during 2005-2015. Mouse monoclonal anti-human Endocan/ESM-1 Clone MEP08 was used at a dilution of 1:400 for immunohistochemical (IHC) staining. All the information was collected by a checklist, and the association between clinicopathological features and high or low levels of Endocan -MVD was evaluated using Pearson chi-square, Fischer's exact, or Monte Carlo tests. Results:The prevalence of Endocan positivity was significantly higher in malignant compared to borderline and benign ovarian tumors (P<0.001). There was also a significant association between type of tumor and Endocan status in malignant ovarian tumors (P=0.02), indicating that Endocan positivity was more likely in serous malignant ovarian tumors compared to other ovarian tumor types. However, the tumor stage was not significantly associated with Endocan status (P=0.31). Conclusion:This study showed that Endocan positivity may show the highest prevalence among malignant tumors suggesting that high Endocan expression would be negatively associated with ovarian tumor behavior.

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Elevated IL‐17A and IL‐22 regulate expression of inducible CD38 and Zap‐70 in chronic lymphocytic leukemia

Cited by 12 publications

References 31 publications

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role

Genetics of blood malignancies among Iranian population: an overview

Significance of Endocan Expression in Various Types of Epithelial Ovarian Tumors

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