Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

Wium‐Andersen, Marie Kim; Ørsted, David D.; Nielsen, Sune F.; Nordestgaard, Børge G.

doi:10.1001/2013.jamapsychiatry.102

Cited by 415 publications

(262 citation statements)

References 38 publications

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“…However, in a prospective analysis, increasing CRP levels were associated with increasing risk for hospitalisation with depression (Wium-Andersen et al, 2013). Greater CRP levels were also identified as an independent risk marker for de novo depression in women (Pasco et al, 2010).…”

Section: The Potential Of Biomarkers To Predict the Onset Of Depressionmentioning

confidence: 89%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

302

180

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Biomarkers are regularly used in medicine to provide objective indicators of normal biological processes, pathogenic processes or pharmacological responses to therapeutic interventions, and have proved invaluable in expanding our understanding and treatment of medical diseases. In the field of psychiatry, assessment and treatment has, however, primarily relied on patient interviews and questionnaires for diagnostic and treatment purposes. Biomarkers in psychiatry present a promising addition to advance the diagnosis, treatment and prevention of psychiatric diseases. This review provides a summary on the potential of peripheral biomarkers in major depression with a specific emphasis on those related to inflammatory/immune and oxidative stress/antioxidant defences. The complexities associated with biomarker assessment are reviewed specifically around their collection, analysis and interpretation. Focus is placed on the potential of peripheral biomarkers to aid diagnosis, predict treatment response, enhance treatment-matching, and prevent the onset or relapse of major depression.

show abstract

Section: The Potential Of Biomarkers To Predict the Onset Of Depressionmentioning

confidence: 89%

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Lopresti

Maker

Hood

et al. 2014

Progress in Neuro-Psychopharmacology and Biological Psychiatry

302

180

View full text Add to dashboard Cite

show abstract

“…This categorization has been used in previous studies of CRP and depression. 3 To assess the association of depressive symptoms with CRP levels, we built linear regression models using logtransformed CRP levels as the outcome. CRP levels were log transformed to approximate normality because CRP levels were skewed.…”

Section: Crp Level Association With Depressive Symptomsmentioning

confidence: 99%

Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide

Cepeda¹,

Stang²,

Makadia³

2016

J. Clin. Psychiatry

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“…They concluded that MDD reduced levels of ferritin, transferrin and fibrinogen in CVD in a gender specific way. 17 Another two studies concluded that depression is associated with decreased levels of serum ferritin concentrations. 18 But there are studies which did not find any significant association.…”

Section: Discussionmentioning

confidence: 99%

Role of inflammation as reflected by serum hsCRP and ferritin level in major depressive disorder

et al. 2016

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Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

Cited by 415 publications

References 38 publications

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Depression Is Associated With High Levels of C-Reactive Protein and Low Levels of Fractional Exhaled Nitric Oxide

Role of inflammation as reflected by serum hsCRP and ferritin level in major depressive disorder

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