Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

An Analysis on the Impact of Childhood Adversity, Anxiety, and C-Reactive Protein on Adult Chronic Pain in the Midlife in the United States (MIDUS) Study

“…These findings differ from those of a Denmark crosssectional and prospective study of 73,131 individuals, where higher CRP level predicted greater psychological distress, depression symptoms, or risk of hospitalization (with depression) 4 to 12 years later in young, middle-aged, or older adults (32). Contrary to previous CRP research, it did not find that the association disappeared when adjusting for confounding variables such as BMI and chronic disease (32). In this way, the present results differed in that anxiety did not have an impact in any of the regression interactions, whereas sociodemographic variables did play a substantial role.…”

“…Significant interactions to explain chronic pain included CAs interacting with each other and CRP with sociodemographic variables such as income and education level. These findings differ from those of a Denmark cross-sectional and prospective study of 73,131 individuals, where higher CRP level predicted greater psychological distress, depression symptoms, or risk of hospitalization (with depression) 4 to 12 years later in young, middle-aged, or older adults (32). Contrary to previous CRP research, it did not find that the association disappeared when adjusting for confounding variables such as BMI and chronic disease (32).…”

Prevalence and correlates of low-grade systemic inflammation in adult psychiatric inpatients: An electronic health record-based study

“…Our results are in line with previous studies reporting prevalence of low-grade inflammation (CRP >3 mg/L) in depression ( Cizza et al, 2009 ; Raison et al, 2013 ; Wium-Andersen et al, 2013 ). These studies have investigated inflammation in depression in specific contexts such as in premenopausal women, in depressed outpatients, or in the general population.…”

Association between Elevated C-Reactive Protein and Manic Polarity in Acute Psychiatric Inpatients with Affective Symptomatology

“…The results show elevated CRP levels in patients hospitalized due to manic exacerbation compared to depressed exacerbation, suggesting that, in affective patients, manic polarity has a stronger link to inflammation compared to depressed polarity. The results of this study concur with recent reports suggesting increased immune activation in bipolar patients compared to non-bipolar patients [2, 3, 7, 9, 16-20], and increased immune activation in manic patients compared both to the non-manic bipolar patients and the non-bipolar patients [9, 14, 15, 17, 21-23]. However, in those studies, patients were selected and categorized based on their DSM diagnoses, while we employed a transdiagnositc approach and included all inpatients with acute affective exacerbation leading to hospitalization, regardless of their primary DSM diagnoses.…”