Element distribution in the corrosion layer and cytotoxicity of alloy Mg–10Dy during in vitro biodegradation

Yang, Lei; Hort, Norbert; Laipple, Daniel; Höche, Daniel; Huang, Yuanding; Kainer, Karl Ulrich; Willumeit‐Römer, Regine; Feyerabend, Frank

doi:10.1016/j.actbio.2012.10.001

Cited by 90 publications

(60 citation statements)

References 43 publications

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“…It could be shown that in cell culture environment degradation rates more similar to those observed in vivo could be obtained 8 . Moreover, in this artificial environment additional chemical reactions are taking place, which lead to a very complex degradation environment, also more comparable to the findings in vivo 5,6,[9][10][11] .…”

Section: Introductionsupporting

confidence: 81%

Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Feyerabend

Dose

et al. 2016

SPIE Proceedings

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The use of degradable magnesium based implants is becoming clinically relevant, e.g. for the use as bone screws. Still there is a lack of analyzing techniques to characterize the in vitro degradation behavior of implant prototypes. The aim of this study was to design an in situ environment to continuously monitor the degradation processes under physiological conditions by time-lapse SRµCT. The use of physiological conditions was chosen to get a better approach to the in vivo situation, as it could be shown by many studies, that these conditions change on the one hand the degradation rate and on the other hand also the formed degradation products. The resulting in situ environment contains a closed bioreactor system to control and monitor the relevant parameters (37°C, 5 % O 2 , 20 % CO 2 ) and to grant sterility of the setup. A flow cell was designed and manufactured from polyether etherketone (PEEK), which was chosen because of the good mechanical properties, high thermal and chemical resistance and radiographic translucency. Sterilization of the system including the sample was reached by a transient flush with 70 % ethanol and subsequent replacement by physiological medium (Modified Eagle Medium alpha). As proof of principle it could be shown that the system remained sterile during a beamtime of several days and that the continuous SRµCT imaging was feasible.

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Section: Introductionsupporting

confidence: 81%

Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Feyerabend

Dose

et al. 2016

SPIE Proceedings

Self Cite

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“…51,52 On the contrary, a previous study showed that the cell viability of osteoblasts was not reduced below 70% for a Mg-10Dy alloy. 53 The reduced relative metabolic activity of the Mg-10Dy alloy may be attributable to an increased Mg 2þ content in the extract. 53 In vitro experiments have shown increases in pH values during degradation of magnesium alloys because of the production of OH À .…”

Section: Discussionmentioning

confidence: 99%

“…53 The reduced relative metabolic activity of the Mg-10Dy alloy may be attributable to an increased Mg 2þ content in the extract. 53 In vitro experiments have shown increases in pH values during degradation of magnesium alloys because of the production of OH À . 9 The optimal pH of HOB is within the range of 7.0-7.6.…”

Section: Discussionmentioning

confidence: 99%

Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

et al. 2014

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Degradable magnesium alloys are promising biomaterials for orthopedic applications. The aim of this study was to evaluate the potential effects on both the synovial membrane (synovialis) and the synovial fluid (synovia) of the degradation products of a MgYREZr-pin implanted in the intercondylar femoral notch in a rabbit model. Thirty-six animals were randomized into two groups (MgYREZr or Ti6Al4V alloy) of 18 animals each. Each group was then divided into three subgroups with implantation periods of 1, 4, and 12 weeks, with six animals in each subgroup. The initial inflammatory reaction caused by the surgical trauma declined after 12 weeks of implantation, and elucidated a progressive recovery of the synovial membrane. Compared with control Ti6Al4V pins, there were no significant differences between the groups. However, after 12 weeks, recovery of the synovial membrane was more advanced in the titanium group, in which 92% showed no signs of synovitis, than in the magnesium group. A cytotoxicity test with L929 cells and human osteoblasts (HOB) was also conducted, according to EN ISO 10993-5/12, and no toxic leachable products were observed after 24 h of incubation. In conclusion, the MgYREZr alloy seems to be a suitable material for intra-articular degradable implants.

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“…However, these β′ precipitates show no adverse effect on the corrosion rate. In CCM, a protective corrosion film forms on the surface of Mg alloys during corrosion [23]. Moreover, organic materials such as proteins would be adsorbed on the surface of the corrosion film [23].…”

Section: Corrosionmentioning

confidence: 99%

“…Previous work has shown that Mg-10Dy alloy has a low corrosion rate, uniform corrosion behavior and good cytocompatibility [22,23]. However, the mechanical properties of Mg-10Dy alloy are not satisfactory.…”

Section: Introductionmentioning

confidence: 98%

Microstructure, mechanical and corrosion properties of Mg–Dy–Gd–Zr alloys for medical applications

et al. 2013

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In previous investigations Mg-10Dy (wt.%) alloy with a good combination of corrosion resistance and cytocompatibility showed a great potential for the use as biodegradable implant material. However, the mechanical properties of Mg-10Dy alloy are not satisfactory. In order to allow the tailoring of mechanical properties required for various medical applications, four Mg-10(Dy+Gd)-0.2Zr (wt.%) alloys were investigated with respect to microstructure, mechanical and corrosion properties.With the increase of Gd content, the amount of second phase particles increased in the as-cast alloys and the age hardening response increased at 200 °C. The yield strength increased while the ductility reduced especially for peak-aged alloys with the addition of Gd. Additionally, with increasing Gd content, the corrosion rate increased in the as-cast condition due to galvanic effect, but all the alloys have a similar corrosion rate (about 0.5 mm/year) in solution treated and aged condition.

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Element distribution in the corrosion layer and cytotoxicity of alloy Mg–10Dy during in vitro biodegradation

Cited by 90 publications

References 43 publications

Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Magnesium degradation observed in situ under flow by synchrotron radiation based microtomography

Biodegradation of a magnesium alloy implant in the intercondylar femoral notch showed an appropriate response to the synovial membrane in a rabbit model in vivo

Microstructure, mechanical and corrosion properties of Mg–Dy–Gd–Zr alloys for medical applications

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