Electrostatics of nanosystems: Application to microtubules and the ribosome

Abstract

T he importance of electrostatic modeling to biophysics is well established; electrostatics have been shown to influence various aspects of nearly all biochemical reactions. Advances in NMR, x-ray, and cryo-electron microscopy techniques for structure elucidation have drastically increased the size and number of biomolecules and molecular complexes for which coordinates are available. However, although the biophysical community continues to examine macromolecular systems of increasing scale, the computational…