Electrospun PLGA/PCL/OCP nanofiber membranes promote osteogenic differentiation of mesenchymal stem cells (MSCs)

Wang, Zetao; Liang, Ruiming; Jiang, Xianfang; Xie, Jing; Cai, Peian; Chen, Haimin; Zhan, Xintang; Lei, Danqing; Zhao, Jinmin; Zheng, Li

doi:10.1016/j.msec.2019.109796

Cited by 46 publications

(28 citation statements)

References 34 publications

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“…One of the most promising approaches involves the use of mesenchymal stem cells (MSCs) that are seeded into 3D scaffolds and induce bone generation by osteoinductive cues [1,[4][5][6][7]. The design of such 3D scaffolds as a bone void filler can be implemented at the interface of organic chemistry, polymer chemistry, material science and cell biology by the development of the composites containing biodegradable synthetic polymers and calcium phosphates [8][9][10][11]. This approach seems to be prospective due to the variability of polymer characteristics [12][13][14][15] and osteoinductivity of calcium and phosphate ions [16,17].…”

Section: Introductionmentioning

confidence: 99%

Osteogenic Differentiation of Human Adipose Tissue-Derived MSCs by Non-Toxic Calcium Poly(ethylene phosphate)s

Nifant’ev

Бухарова

Dyakonov

et al. 2019

IJMS

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P.I.) 2 A.V. Topchiev Institute of Petrochemical Synthesis RAS, 29 Leninsky Pr.,Abstract: There is a current clinical need for the development of bone void fillers and bioactive bone graft substitutes. The use of mesenchymal stem cells (MSCs) that are seeded into 3D scaffolds and induce bone generation in the event of MSCs osteogenic differentiation is highly promising. Since calcium ions and phosphates promote the osteogenic differentiation of MSCs, the use of the calcium complexes of phosphate-containing polymers is highly prospective in the development of osteogenic scaffolds. Calcium poly(ethylene phosphate)s (PEP-Ca) appear to be potentially suitable candidates primarily because of PEP's biodegradability. In a series of experiments with human adipose-tissue-derived multipotent mesenchymal stem cells (ADSCs), we demonstrated that PEP-Ca are non-toxic and give rise to osteogenesis gene marker, bone morphogenetic protein 2 (BMP-2) and mineralization of the intercellular matrix. Owing to the synthetic availability of poly(ethylene phosphoric acid) block copolymers, these results hold out the possibility for the development of promising new polymer composites for orthopaedic and maxillofacial surgery.

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Section: Introductionmentioning

confidence: 99%

Osteogenic Differentiation of Human Adipose Tissue-Derived MSCs by Non-Toxic Calcium Poly(ethylene phosphate)s

Nifant’ev

Бухарова

Dyakonov

et al. 2019

IJMS

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“…Figure 5 shows the FTIR results of tissue engineering stents, PVA-PCL/PEG-PEO stents, and the raw materials, which indicate the chemical composition. The test results show that the characteristic peaks of PCL are presented at 2882 cm −1 for stretch of CH 2 , 1726 cm −1 for C=O tensile, and 1099 cm −1 for stretch of C-O [21,22]. Regarding PEG, the stretches of C-H and C-O are presented at 2882 and 1099 cm −1 , respectively.…”

Section: Morphology Observation Of Tissue Engineering Stentsmentioning

confidence: 96%

Tissue engineering stent model with long fiber-reinforced thermoplastic technique

Lin

Huang

et al. 2020

J Mater Sci: Mater Med

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This study aims to construct tissue engineering stents by using the long fiber-reinforced thermoplastic (LFT) technique to develop artery stents. The experimental method combines fibers, the LFT technique, and electrospinning technique. First, the biodegradable polyvinyl alcohol yarns are twisted and coated in polycaprolactone/polyethylene glycol blends through the LFT technique. Next, the weft-knitting and heat treatment are used to establish the stent structure, after which poly (ethylene oxide) (PEO) is electrospun to coat the stents. The morphology, mechanical, and biological properties of tissue engineering stents are evaluated. The test results indicated that the use of the LFT technique retains the softness of filaments, which facilitates the subsequent weft-knitting process. The coating of blends and electrospinning of PEO have a positive influence on the tissue engineering stents, as demonstrated by the tensile strength of 59.93 N and compressive strength of 6.10 N. Moreover, the in vitro degradation of stents exhibits a stabilized process. The water contact angle is 20.33°, and the cell survival rate in 24 h is over 80%. The proposed tissue engineering stents are good candidates for artery stent structure.

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“…Type I and type III collagens derived from bovine and porcine are the commonly used materials for natural polymer membranes (Figure 1(A)) [66,67].…”

Section: Natural Polymersmentioning

confidence: 99%

Barrier membranes for tissue regeneration in dentistry

Sasaki

Abe

et al. 2021

Biomaterial Investigations in Dentistry

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Background: In dentistry, barrier membranes are used for guided tissue regeneration (GTR) and guided bone regeneration (GBR). Various membranes are commercially available and extensive research and development of novel membranes have been conducted. In general, membranes are required to provide barrier function, biosafety, biocompatibility and appropriate mechanical properties. In addition, membranes are expected to be bioactive to promote tissue regeneration.Objectives: This review aims to organize the fundamental characteristics of the barrier membranes that are available and studied for dentistry, based on their components. Results: The principal components of barrier membranes are divided into nonbiodegradable and biodegradable materials. Nonbiodegradable membranes are manufactured from synthetic polymers, metals or composites of these materials. The first reported barrier membrane was made from expanded polytetrafluoroethylene (e-PTFE). Titanium has also been applied for dental regenerative therapy and shows favorable barrier function. Biodegradable membranes are mainly made from natural and synthetic polymers. Collagens are popular materials that are processed for clinical use by crosslinking. Aliphatic polyesters and their copolymers have been relatively recently introduced into GTR and GBR treatments. In addition, to improve the tissue regenerative function and mechanical strength of biodegradable membranes, inorganic materials such as calcium phosphate and bioactive glass have been incorporated at the research stage. Conclusions: Currently, there are still insufficient guidelines for barrier membrane choice in GTR and GBR, therefore dentists are required to understand the characteristics of barrier membranes.

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Electrospun PLGA/PCL/OCP nanofiber membranes promote osteogenic differentiation of mesenchymal stem cells (MSCs)

Cited by 46 publications

References 34 publications

Osteogenic Differentiation of Human Adipose Tissue-Derived MSCs by Non-Toxic Calcium Poly(ethylene phosphate)s

Osteogenic Differentiation of Human Adipose Tissue-Derived MSCs by Non-Toxic Calcium Poly(ethylene phosphate)s

Tissue engineering stent model with long fiber-reinforced thermoplastic technique

Barrier membranes for tissue regeneration in dentistry

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