Electrospun fibers for the treatment of skin diseases

Gürtler, Anna-Lena; Rades, Thomas; Heinz, Andrea

doi:10.1016/j.jconrel.2023.10.009

Cited by 7 publications

(3 citation statements)

References 190 publications

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“…All the samples exhibited an average thickness ranging from approximately 0.70 to 0.85 mm, as depicted in Figure S3. We believe this thickness is suitable for their potential application as antimicrobial patches (e.g., for topical application in skin). − Furthermore, there is a noticeable change in color and intensity as the concentration of TPPF 20 -Zn increases: EC mats are entirely white, and the addition of TPPF 20 -Zn into the polymeric solution transforms the color to pink, corroborating the inclusion of the porphyrin. Additionally, the intensity is higher in the case of EC/TPPF 20 -Zn-2 compared to EC/TPPF 20 -Zn-1.…”

Section: Resultsmentioning

confidence: 99%

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

González López,

Palacios,

Martinez

et al. 2024

ACS Appl. Polym. Mater.

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A system composed of ethylcellulose (EC) nanofibers loading with [5,10,15,20-tetrakis(pentafluorophenyl)porphyrinato]zinc(II) (TPPF 20 -Zn) was developed as electrospun mats to contribute to the inactivation of resistant bacteria strains. This tetrapyrrolic macrocycle was chosen for its excellent photostability and straightforward large-scale preparation, which are crucial attributes for practical applications. The synthesis and subsequent characterization of TPPF 20 -Zn demonstrated scalability and its ability to generate reactive oxygen species (ROS). Subsequently, nanofibrous mats based on EC loaded with different amounts of the porphyrin were obtained using the single-nozzle electrospinning technique after dissolution in a binary solvent mix of N,Ndimethylacetamide/ethanol. The fibers exhibited an adequate morphology at the nanoscale, a narrow diameter distribution, and an absence of beads. Additionally, the thermal and surface properties of the systems were analyzed, revealing no significant changes upon porphyrin incorporation. The developed electrospun composite nanofibrous mats demonstrated the capability to photokill Escherichia coli, as confirmed in planktonic suspension and using advanced fluorescence microscopy. Considering all the studies reported herein, we believe that the EC/TPPF 20 -Zn mats show promise for practical application in the field of antimicrobial patches or self-sterilizing surfaces.

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Section: Resultsmentioning

confidence: 99%

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

González López,

Palacios,

Martinez

et al. 2024

ACS Appl. Polym. Mater.

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“…This textile-based therapy is a wellestablished method used in the treatment of skin diseases. 26 To effectively treat atopic dermatitis, a sustained release is desired to provide constant drug concentration and keep the skin hydration level high. 27 Thus, skin patches are widely used in dermatology because they deliver the desired substances directly to the skin.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Hydrating formulas can be applied either directly to the skin surface or delivered from patches applied on the skin. This textile-based therapy is a well-established method used in the treatment of skin diseases …”

Section: Introductionmentioning

confidence: 99%

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

Sroczyk,

Tarasiuk,

Talar

et al. 2024

ACS Appl. Mater. Interfaces

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Atopic skin is dry and itchy and lacks integrity. Impaired skin barrier results from altered lipid composition of the skin. A crucial skin lipid, cholesterol, provides flexibility and homeostasis of the cell membranes' lipid bilayer. Cholesterol-based creams and natural oils, especially blackcurrant seed oil, are beneficial for skin care as they hydrate the skin and improve its integrity. The major atopic symptom, skin dryness, can be overcome by the application of porous patches enhanced with cholesterol and natural oil. The base of the patches is constructed of polyimide (PI) nanofibers with cholesterol coatings and externally added blackcurrant seed oil. The presence of cholesterol in PI mats hinders the passage of oil through the patches to the skin, resulting in sustained and prolonged skin hydration. The theoretical and numerical investigations of oil dynamics in porous mats confirmed the experimental results, showing a prolonged skin hydration effect up to 6 h. Additionally, as demonstrated by in vivo tests on atopic mice, cholesterol patches lower serum immunoglobulin E levels and expression of proinflammatory cytokines in the skin, thereby accelerating skin healing. Our results hold great promise for the longterm application of the patches in atopic dermatitis treatment.

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A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing

Zhang,

Wu,

Gong

et al. 2024

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Chronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus‐responsive glycopeptide hydrogel constructed by oxidized Bletilla striata polysaccharide (OBSP), gallic acid‐grafted ε‐Polylysine (PLY‐GA), and paeoniflorin‐loaded micelles (MIC@Pae), called OBPG&MP. The hydrogel emulates the structure of glycoprotein fibers of the extracellular matrix (ECM), exhibiting exceptional injectability, self‐healing, and biocompatibility. It adapts responsively to the inflammatory microenvironment of chronic wounds, sequentially releasing therapeutic agents to eradicate bacterial infection, neutralize reactive oxygen species (ROS), modulate macrophage polarization, suppress inflammation, and encourage vascular regeneration and ECM remodeling, playing a critical role across the inflammatory, proliferative, and remodeling phases of wound healing. Both in vitro and in vivo studies confirmed the efficacy of OBPG&MP hydrogel in regulating the wound microenvironment and enhancing the regeneration and remodeling of chronic wound skin tissue. This research supports the vast potential for herb‐derived multifunctional hydrogels in tissue engineering and regenerative medicine.

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Electrospun fibers for the treatment of skin diseases

Cited by 7 publications

References 190 publications

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

Light-Activated Antibacterial Ethylcellulose Electrospun Nanofibrous Mats Containing Fluorinated Zn(II) Porphyrin

Cholesterol Nanofiber Patches with Sustainable Oil Delivery Eliminate Inflammation in Atopic Skin

A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing

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