Electrospun collagen–chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell

Chen, Z.G.; Wang, P.W.; Wei, Bo; Mo, Xiu; Cui, Fu Zhai

doi:10.1016/j.actbio.2009.07.024

Cited by 339 publications

(217 citation statements)

References 23 publications

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…Chitosan is soluble in acidic solution but the chitosan solution becomes highly viscous when its concentration goes high, making the preparation of chitosan nanofibers by electrospinning quite problematic. To overcome this difficulty, chitosan has to dissolve in high concentration of acetic acid or organic solvents such as trifluotoacetic acid (TFA) and hexafluoroisopropanol (HFIP) [14][15][16]. However, TFA and HFIP are highly corrosive and expensive.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

et al. 2017

View full text Add to dashboard Cite

It is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.

show abstract

Section: Introductionmentioning

confidence: 99%

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recently, a library of various polymer-solvent combinations which has a crucial role in transforming chitosan into nanofibers has been developed for many ground breaking applications in different disciplines of biomedical technology such as such as in tissue engineering, wound healing, drug delivery, and anti-bacterial applications [33,34,[40][41][42][43][44][45][46][47]. These studies as well as steady state growth of number of publications of chitosan based nanofibers in each year (Figure 3) demonstrate enormous potential of chitosan nanofibers in the biomedical field.…”

Section: Progress In Eletrospinning Of Chitosanmentioning

confidence: 98%

Nanofibrous Structure of Chitosan for Biomedical Applications

Bhattarai¹

2012

J Nanomedic Biotherapeu Discover

View full text Add to dashboard Cite

“…The constructs showed no cytotoxicity toward growth of 3T3 FBs and had good in vitro biocompatibility [30]. In another study, collagen blended with chitosan showed both endothelial cell (EC) and smooth muscle cell (SMC) proliferation on or within the nanofibers [31]. Yeo et al used collagen and SF to create two types of electrospun scaffolds, a blend scaffold and a hybrid scaffold.…”

Section: Electrospinning Collagen and Natural Polymer Blendsmentioning

confidence: 99%

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

et al. 2010

View full text Add to dashboard Cite

Natural polymers such as collagens, elastin, and fibrinogen make up much of the body's native extracellular matrix (ECM). This ECM provides structure and mechanical integrity to tissues, as well as communicating with the cellular components it supports to help facilitate and regulate daily cellular processes and wound healing. An ideal tissue engineering scaffold would not only replicate the structure of this ECM, but would also replicate the many functions that the ECM performs. In the past decade, the process of electrospinning has proven effective in creating non-woven ECM analogue scaffolds of micro to nanoscale diameter fibers from an array of synthetic and natural polymers. The ability of this fabrication technique to utilize the aforementioned natural polymers to create tissue engineering scaffolds has yielded promising results, both in vitro and in vivo, due in part to the enhanced bioactivity afforded by materials normally found within the human body. This review will present the process of electrospinning and describe the use of natural polymers in the creation of bioactive ECM analogues in tissue engineering.

show abstract

Electrospun collagen–chitosan nanofiber: A biomimetic extracellular matrix for endothelial cell and smooth muscle cell

Cited by 339 publications

References 23 publications

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Nanofibrous Structure of Chitosan for Biomedical Applications

The Use of Natural Polymers in Tissue Engineering: A Focus on Electrospun Extracellular Matrix Analogues

Contact Info

Product

Resources

About