Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Chang, Jau-Yang; Lee, Yen Hsien; Wu, Meng Hsiu; Yang, Ming; Chien, Chiang Ting

doi:10.1016/j.carbpol.2012.02.011

Cited by 64 publications

(32 citation statements)

References 43 publications

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“…Because silk easily forms β‐sheet secondary structures, giving it a smooth surface, silk is a good material candidate as an anti‐adhesion material. However, previous anti‐adhesion material studies mainly focused on synthetic polymers, such as poly( l ‐lactic acid), polyethylene glycol (PEG), poly(D,L‐lactic‐co‐glycolic acid), poly(ethylene oxide) (PEO), poly(vinyl alcohol) (PVA), and poly(lactide)‐b‐poly(ethylene glycol); Recently, some studies have evaluated natural polymers, such as chitosan and sodium alginate and hyaluronic acid Peritoneal adhesions are the most common complication after abdominal surgery, often leading to chronic pelvic pain, infertility, and even bowel obstruction. The best methods for preventing adhesion involve minimizing abdominal trauma, maintaining hemostasis, avoiding infection, and applying tension sutures.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Wang

Bai

Hsu

et al. 2017

J Biomedical Materials Res

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A novel anti-adhesion nonwoven mat mainly composed of silk fibroin protein (SFP) was fabricated via the single-spinneret electrospinning technique. A series of SFPbased electrospun nonwoven mats containing additives of different synthetic polymer ratios, such as pure SFP, SFP/poly(vinyl alcohol) (PVA), SFP/polyethylene glycol (PEG), and SFP/ polyethylene oxide (PEO) were produced and compared. All membranes were porous and had diameters of 324.02 6 113.7, 308.86 6 74.02, 366.22 6 115.81, and 341.82 6 119.42 nm, respectively. The average pore size for each membrane was

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Section: Introductionmentioning

confidence: 99%

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Wang

Bai

Hsu

et al. 2017

J Biomedical Materials Res

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“…Natural polymers, however, have excellent biocompatibility. Natural polymer based antiadhesives utilize materials such as hyaluronic acid, chitosan, and carboxymethylcellulose . A number of products showed good clinical results in abdominal surgery .…”

Section: Discussion and Conclusionmentioning

confidence: 99%

“…Natural polymer based antiadhesives utilize materials such as hyaluronic acid, chitosan, and carboxymethylcellulose. [28][29][30] A number of products showed good clinical results in abdominal surgery. [31][32][33] Most natural polymer based products, however, are biomechanically weak and degrade too quickly to be used during tendon surgery.…”

Section: Discussionmentioning

confidence: 99%

Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

et al. 2019

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Cartilage extracellular matrix contains antiadhesive and antiangiogenic molecules such as chondromodulin‐1, thrombospondin‐1, and endostatin. We have aimed to develop a cross‐linked cartilage acellular matrix (CAM) barrier for peritendinous adhesion prevention. CAM film was fabricated using decellularized porcine cartilage tissue powder and chemical cross‐linking. Biochemical analysis of the film showed retention of collagen and glycosaminoglycans after the fabrication process. Physical characterization of the film showed denser collagen microstructure, increased water contact angle, and higher tensile strength after cross‐linking. The degradation time in vivo was 14 d after cross‐linking. The film extract and film surface showed similar cell proliferation, while inhibiting cell migration and cell adhesion compared to standard media and culture plate, respectively. Application of the film after repair resulted in similar tendon healing and significantly less peritendinous adhesions in a rabbit Achilles tendon injury model compared to repair only group, demonstrated by histology, ultrasonography, and biomechanical testing. In conclusion, the current study developed a CAM film having biological properties of antiadhesion, together with biomechanical properties and degradation profile suitable for prevention of peritendinous adhesions.

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“…Despite the fact that the aim of this study was to reduce peritoneal adhesions, the outcomes could be easily translated to tendon tissues, particularly affected by adhesion formation, and consequently with limitation in restoring local tissue function [51]. Despite the fact that the aim of this study was to reduce peritoneal adhesions, the outcomes could be easily translated to tendon tissues, particularly affected by adhesion formation, and consequently with limitation in restoring local tissue function [51].…”

Section: Chitosanmentioning

confidence: 98%

Biomaterials in Preclinical Approaches for Engineering Skeletal Tissues

Rodrigues

Carvalho

Gomes

et al. 2015

Translational Regenerative Medicine

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Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Cited by 64 publications

References 43 publications

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Evaluation of a series of silk fibroin protein‐based nonwoven mats for use as an anti‐adhesion patch for wound management in robotic surgery

Cross‐linked cartilage acellular matrix film decreases postsurgical peritendinous adhesions

Biomaterials in Preclinical Approaches for Engineering Skeletal Tissues

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