Electrospinning of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-graft-polylactic acid to produce a fibrillar scaffold

Pitarresi, Giovanna; Palumbo, Fabio Salvatore; Fiorica, Calogero; Calascibetta, Filippo; Giammona, Gaetano

doi:10.1016/j.eurpolymj.2009.09.001

Cited by 20 publications

(11 citation statements)

References 12 publications

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“…In a preliminary work, we demonstrated that PHEA-g-PLA electrospun scaffolds, after 15 days in DPBS pH 7.4 undergo a partial degradation with a loss of micro-pieces due to a slight erosion and not to a chemical hydrolysis of the copolymer. 15 However, for degradation time longer than 15 days, it is reasonable to suppose that a chemical degradation of the copolymer could also occur as demonstrated previously for gels based on PHEA-g-PLA. 8 In any case, even after 28 days, that is, when there is a significant loss of initial weight of each scaffold, fibers are still observed, as showed by SEM images of scaffolds recovered after incubation in DPBS pH 7.4 as a function of time (Fig.…”

Section: Synthesis Of Phea-g-pla-(ibu)mentioning

confidence: 75%

“…In a preliminary work, we demonstrated that PHEA‐ g ‐PLA electrospun scaffolds, after 15 days in DPBS pH 7.4 undergo a partial degradation with a loss of micro‐pieces due to a slight erosion and not to a chemical hydrolysis of the copolymer 15. However, for degradation time longer than 15 days, it is reasonable to suppose that a chemical degradation of the copolymer could also occur as demonstrated previously for gels based on PHEA‐ g ‐PLA 8…”

Section: Resultsmentioning

confidence: 96%

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Polyaspartamide‐polylactide electrospun scaffolds for potential topical release of Ibuprofen

Pitarresi

Fiorica

Palumbo

et al. 2012

J Biomedical Materials Res

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In this work, the production and characterization of electrospun scaffolds of the copolymer α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA), proposed for a potential topical release of Ibuprofen (IBU), are reported. The drug has been chemically linked to PHEA-g-PLA and/or physically mixed to the copolymer before electrospinning. Degradation studies have been performed as a function of time in Dulbecco phosphate buffer solution pH 7.4, for both unloaded and drug-loaded scaffolds. By using an appropriate ratio between drug physically blended to the copolymer and drug-copolymer conjugate, a useful control of its release can be obtained. MTS assay on human dermal fibroblasts cultured onto these scaffolds, showed the absence of toxicity as well as their ability to allow cell adhesion.

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Section: Synthesis Of Phea-g-pla-(ibu)mentioning

confidence: 75%

Section: Resultsmentioning

confidence: 96%

Polyaspartamide‐polylactide electrospun scaffolds for potential topical release of Ibuprofen

Pitarresi

Fiorica

Palumbo

et al. 2012

J Biomedical Materials Res

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“…27 It is mostly used for biomedical implementations such as sutures, scaffolds and drug delivery systems. 28,29,66 The polymer is compostable and is formed either by direct condensation of lactic acid or by the cyclic intermediate dimer through a ring opening process. The conventional melt spinning method can be used for processing PLA fibres.…”

Section: -Dimensional (3d) Printed Wound Dressingsmentioning

confidence: 99%

A review of wound management materials

Uzun¹

2018

JTEFT

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Wound dressing is one of the main external effectors during the healing process of wounds. The following characteristics are required for ideal modern and smart wound dressings; bioadhesiveness to the wound surface, ease of applications, easily sterilised, inhibition of bacterial invasion, biodegradability, oxygen permeability, nontoxic, etc. There is a growing concern about the usage of smart materials as wound dressings. These are natural polymers such as polysaccharides and derivatives (e.g., carboxymethlycellulose, alginates, chitosan and heparin), proteoglycans and proteins (e.g., collagen, gelatine, fibrin, and keratin), and what is more, the impact of such materials on the wound healing process is still under investigation by scientists and experts in general. Development of wound dressing materials is main objectives of this paper which will provide general information on future wound dressing materials.

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“…In previous works, we have performed electrospinning of PHEA‐g‐PLA copolymer and prepared fibrillar scaffolds where drug molecules have been linked to hydroxyl groups of PHEA …”

Section: Introductionmentioning

confidence: 99%

“…In previous works, we have performed electrospinning of PHEA-g-PLA copolymer and prepared fibrillar scaffolds where drug molecules have been linked to hydroxyl groups of PHEA. 8,9 Now, PHEA-EDA-g-PLA has been electrospun in the presence of polycaprolactone (PCL), this latter already used for the production of electrospun vascular grafts. 10 Thanks to the presence of free amino and hydroxyl groups in PHEA-EDA-g-PLA, the electrospun scaffold has been bound to heparin, a known natural anticoagulant molecule.…”

Section: Introductionmentioning

confidence: 99%

Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration

Pitarresi

Fiorica

Palumbo

et al. 2013

J Biomedical Materials Res

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An interesting issue in tissue engineering is the development of a biodegradable vascular graft able to substitute a blood vessel and to allow its complete regeneration. Here, we report a new scaffold potentially useful as a synthetic vascular graft, produced through the electrospinning of α,β-poly(N-2-hydroxyethyl) (2-aminoethylcarbamate)-D,L-aspartamide-graft-polylactic acid (PHEA-EDA-g-PLA) in the presence of polycaprolactone (PCL). The scaffold degradation profile has been evaluated as well as the possibility to bind heparin to electrospun fibers, being it a known anticoagulant molecule able to bind growth factors. In vitro cell compatibility has been investigated using human vascular endothelial cells (ECV 304) and the ability of heparinized PHEA-EDA-g-PLA/PCL scaffold to retain basic fibroblast growth factor has been evaluated in comparison with not heparinized sample.

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Electrospinning of α,β-poly(N-2-hydroxyethyl)-dl-aspartamide-graft-polylactic acid to produce a fibrillar scaffold

Cited by 20 publications

References 12 publications

Polyaspartamide‐polylactide electrospun scaffolds for potential topical release of Ibuprofen

Polyaspartamide‐polylactide electrospun scaffolds for potential topical release of Ibuprofen

A review of wound management materials

Heparin functionalized polyaspartamide/polyester scaffold for potential blood vessel regeneration

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