Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts

Noh, Hyung Kil; Lee, Sung Won; Kim, Jin Man; Oh, Joo Hyun; Kim, Kyung-Hwa; Chung, Chong-Pyoung; Choi, Sun-Ho; Park, Won Ho; Min, Byung‐Moo

doi:10.1016/j.biomaterials.2006.03.016

Cited by 302 publications

(146 citation statements)

References 24 publications

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“…Electrospinning is a commonly used technology to obtain polymer nanofibers with diameters in the range of several nanometers to micrometers [1][2][3][4]. During the electrospinning process electrostatic repulsion is used to overcome the surface tension of a solution droplet at the needle tip, thus stretching the droplet to form a jet, which dries while flying toward a collector, to produce nanofibers [5].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

et al. 2017

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It is difficult to fabricate chitosan-wrapped coaxial nanofibers, because highly viscous chitosan solutions might hinder the manufacturing process. To overcome this difficulty, our newly developed method, which included the addition of a small amount of gum arabic, was utilized to prepare much less viscous chitosan solutions. In this way, coaxial polyvinyl alcohol (PVA)/chitosan (as core/shell) nanofiber membranes were fabricated successfully by coaxial electrospinning. The core/shell structures were confirmed by TEM, and the existence of PVA and chitosan was also verified using FT-IR and TGA. The tensile strength of the nanofiber membranes was increased from 0.6-0.7 MPa to 0.8-0.9 MPa after being crosslinked with glutaraldehyde. The application potential of the PVA/chitosan nanofiber membranes was tested in drug release experiments by loading the core (PVA) with theophylline as a model drug. The use of the coaxial PVA/chitosan nanofiber membranes in drug release extended the release time of theophylline from 5 minutes to 24 hours. Further, the release mechanisms could be described by the Korsmeyer-Peppas model. In summary, by combining the advantages of PVA and chitosan (good mechanical strength and good biocompatibility respectively), the coaxial PVA/chitosan nanofiber membranes are potential biomaterials for various biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

et al. 2017

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“…Кроме того, ФБ секретируют различные факторы роста и протеазы, необ-ходимые для заживления ран: фактор-2 роста ФБ (FGF2), фактор роста эндотелия сосудов (VEGF), фактор роста ге-патоцитов (HGF) и другие факторы, стимулирующие ми-грацию и пролиферацию клеток различных типов, уча-ствующих в процессах регенерации [10,11]. Поэтому спо-собность МН поддерживать адгезию и пролиферацию ФБ является важным показателем возможности их примене-ния для клеточной терапии кожных ран.…”

Section: рис 2 культивирование мышиных фб линии 3т3 на мн двух типовunclassified

“…Одним из таких материа-лов, обладающих свойствами, необходимыми для культи-вирования клеток, является фиброин -основной компо-нент шелка тутового шелкопряда [4][5][6][7]. Работы по иссле-дованию фиброина как субстрата для культивирования клеток, задействованных в регенерации кожных ран, по-казывают перспективность его использования: фиброин шелка эффективно поддерживает адгезию и пролифера-цию клеток эпидермиса и ФБ [8][9][10][11][12].…”

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Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice

Moisenovich

Куликов²,

Arkhipova

et al. 2015

Ter. arkh.

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“…Recent studies showed that the biocompatibility of chitin and CS nanofibers were found to promote cell attachment and spreading of normal human keratinocytes and fibroblasts. 22 This may be a consequence of the high surface are available for cell attachment and growing. 12 Therefore two types of CS scaffolds can be considered as biocompatible material biologically.…”

Section: 폴리머 제36권 제4호 2012년mentioning

confidence: 99%

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

Lim¹,

Oh²,

Choi³

et al. 2012

Polymer Korea

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For bone regeneration from KUSA-A1 oesteoblast cells (KUSA), chitosan (CS) scaffolds possessing different surface properties, sponge-type (CSS) and nonwoven-type (CSNW), were manufactured. Surface area and pore size of CSNW were larger than those of CSS. On the other hand, the pore volume of CSNW was smaller than that of CSS. Cell attachment evaluation showed CSNW was more adequate then CSS, and this was attributed to the large surface area. For in vivo investigation, KUSA were seeded into CS scaffolds in wells followed by a week of cell culture. Obtained CS scaffolds with KUSA were implanted on the subcutaneous tissue of BALB/C nude mice. After surgery, implanted scaffolds were harvested and assayed by immunological staining. Network stability of CSS was better than that of CSNW, even if CSS scaffolds were destroyed between 4 and 6 weeks. Calcification was observed after 4 and 8 weeks for CSNW and CSS, respectively.

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Electrospinning of chitin nanofibers: Degradation behavior and cellular response to normal human keratinocytes and fibroblasts

Cited by 302 publications

References 24 publications

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Fabrication and application of coaxial polyvinyl alcohol/chitosan nanofiber membranes

Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice

In vivo Bone Regeneration by Using Chitosan Scaffolds with KUSA-A1 Oesteoblast Cells

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