Electrospinning/electrospraying coatings for metal microneedles: A design of experiments (DOE) and quality by design (QbD) approach

Abstract

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Understanding the role of bond point strain in the mechanical response of nonwoven polypropylene materials

“…Electrospinning and electrospraying are both similar electrohydrodynamic processes where micron and sub-micron fibers or particles can be made by utilizing an electrical field as the driving force to atomize liquids. [23][24][25] Simplicity of preparation is the main advantage of these methods; they are flexible, facile, and cost effective 26,24 with applications in drug delivery, food industry, tissue engineering, mass spectrometry, nanodevices, electronics, and filtration. Using electrospraying a liquid that is passing through a capillary with a low flow rate is used as the ink to produce micron/submicron droplets that will be deposited on the collector's surface (made of steel).…”

“…26,27 Various researchers have studied the influence of these parameters in electrospinning [28][29][30][31][32] and electrospraying techniques. 25,27,33,34 Flow rate and voltage are two critical process parameters, higher voltage and lower flow rates provide smaller droplets. Figure 2 presents a schematic of the electrospraying setup.…”

Recent applications of electrical, centrifugal, and pressurised emerging technologies for fibrous structure engineering in drug delivery, regenerative medicine and theranostics

“…chitosan [152][153][154][155][156], collagen [157][158][159][160], SF [161][162][163][164], gelatin [165][166][167][168][169][170]) and synthetic polymers (e.g. PGA [171][172][173], poly lactic acid (PLA) [174][175][176][177][178][179], PLGA [180][181][182][183][184][185][186][187][188], poly vinylpyrrolidone (PVP) [77,[189][190][191][192][193][194], PCL [195][196][197][198][199][200]<...…”

“…The ES process has also found to be advantageous in developing fibrous mats for novel controlled drug delivery systems via an array of administration routes such as buccal [59,371,372], nasal [373][374][375], transdermal [194,376,377] and ocular [378][379][380][381][382]. ES has found to have the ability to overcome limitations of conventional drug delivery routes of administrations e.g.…”

Electrohydrodynamic atomisation driven design and engineering of opportunistic particulate systems for applications in drug delivery, therapeutics and pharmaceutics

“…This method overcomes the challenges associated with the aforementioned ROA, such as poor absorption and degradation of drugs occurring in the gastrointestinal tract or the liver, whilst providing a sustained release of drugs with a single application. It should be noted, only a selective number of medications can be delivered via the transdermal route in therapeutic amounts, however microneedles can be employed to improve transdermal delivery [184][185][186]. Microneedles work by creating micropunctures in the skin through which drugs and nutrients can be transported into deeper layers within the skin.…”