Electroretinographic diagnosis in families with X‐linked retinitis pigmentosa

Abstract

Four families with X-chromosome linked retinitis pigmentosa (14 patients, 14 carriers and 11 normal relatives) were investigated with full-field ERG with computer averaging and an electronic narrow bandpass filter. Reliable ERGs were obtained with 30 Hz flickering white light from 13 out of 14 patients with the disease, all severely affected. Further, B-wave implicit times were found to be more informative than B-wave amplitudes for identifying carriers of the disease. Full-field ERG appears to be a valuable tool for studying X-chromosome linked retinitis pigmentosa families, when necessary supported with computer averaging and a narrow bandpass filter.

Full‐field electroretinogram in a patient with cutaneous melanoma‐associated retinopathy

“…Electroretinograms were recorded in a Nicolet Compact Four analysis system as described previously (Andreasson & Ehinger 1990). After dilatation of the pupil with topical pehnylephrine and cyclopentolate HCl, a Burian-Allen bipolar contact lens ERG electrode was applied together with a ground electrode on the forehead.…”

Full‐field electroretinogram in a patient with cutaneous melanoma‐associated retinopathy

“…Electroretinograms were recorded in a Nicolet Compact Four analysis system as described previously (Andreasson & Ehinger 1990). After dilatation of the pupil with topical pehnylephrine and cyclopentolate HCl, a Burian-Allen bipolar contact lens ERG electrode was applied together with a ground electrode on the forehead.…”

Full‐field electroretinograms in a family with Mohr‐Tranebjaerg syndrome

“…Full-field electroretinograms from all patients were recorded in a Nicolet Compact Four analysis system (Nicolet Biomedical Instruments, Madison, Wisconsin), as described previously (Rabin & Berson 1974;Andreasson & Ehinger 1990;Andreasson et al 1993). Each eye was tested after maximal pupil dilation with topical 10% phenylephrine hydrochloride and 1 % cyclopentolate hydro-chloride, and after 40 min of dark adaption.…”

Full‐field electroretinogram in a patient with cutaneous melanoma‐associated retinopathy

“…Electroretinograms were recorded in a Nicolet Compact Four analysis system as described previously (Andreasson & Ehinger 1990). After dilatation of the pupil with topical pehnylephrine and cyclopentolate HCl, a Burian-Allen bipolar contact lens ERG electrode was applied together with a ground electrode on the forehead.…”

Full‐field electroretinograms in a family with Mohr‐Tranebjaerg syndrome

“…Full-field electroretinograms from all patients were recorded in a Nicolet Compact Four analysis system (Nicolet Biomedical Instruments, Madison, Wisconsin), as described previously (Rabin & Berson 1974;Andreasson & Ehinger 1990;Andreasson et al 1993). Each eye was tested after maximal pupil dilation with topical 10% phenylephrine hydrochloride and 1 % cyclopentolate hydro-chloride, and after 40 min of dark adaption.…”

Full‐field electroretinogram in a patient with cutaneous melanoma‐associated retinopathy

“…Electroretinograms were recorded in a Nicolet Compact Four analysis system as described previously (Andreasson & Ehinger 1990). After dilatation of the pupil with topical pehnylephrine and cyclopentolate HCl, a Burian-Allen bipolar contact lens ERG electrode was applied together with a ground electrode on the forehead.…”

Full‐field electroretinograms in a family with Mohr‐Tranebjaerg syndrome

“…Full-field electroretinograms from all patients were recorded in a Nicolet Compact Four analysis system (Nicolet Biomedical Instruments, Madison, Wisconsin), as described previously (Rabin & Berson 1974;Andreasson & Ehinger 1990;Andreasson et al 1993). Each eye was tested after maximal pupil dilation with topical 10% phenylephrine hydrochloride and 1 % cyclopentolate hydro-chloride, and after 40 min of dark adaption.…”