Electrophysiology of dopamine D-1 receptors in the basal ganglia: Old facts and new perspectives

Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning

“…In contrast, dopamine neurons shift their activity from reward presentation to the associated cue as animals learn [11,12]. The release of dopamine in the striatum is known to enhance dSPN activity through D1 receptors [22,23], a step thought to enhance the likelihood of action initiation [7,24,25]. While our findings are consistent with these models, they further reveal that VS dSPNs are specifically responsive to actions that fulfill the learned CS-reward association.…”

Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning

“…In contrast, dopamine neurons shift their activity from reward presentation to the associated cue as animals learn [11,12]. The release of dopamine in the striatum is known to enhance dSPN activity through D1 receptors [22,23], a step thought to enhance the likelihood of action initiation [7,24,25]. While our findings are consistent with these models, they further reveal that VS dSPNs are specifically responsive to actions that fulfill the learned CS-reward association.…”

Dysregulation of brain dopamine systems in major depressive disorder

“…20 D1-like receptor activation can contribute to either excitation or inhibition, dependent on cell type; D2-like receptor activation is usually inhibitory. [21][22][23] DA signaling is typically terminated by re-uptake of DA through a high-affinity presynaptic transporter (DAT).…”

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

“…DA modulates MSN firing (Cepeda et al 1993;Hernandez-Lopez et al 1997;Surmeier 2006) as well as facilitates changes in synaptic efficacy in the striatum (Calabresi et al 1992;Stefani et al 1995;Schultz 1998;Shen et al 2008). DA likely also filters cortico-basal ganglia input (Rolls et al 1984;Bamford et al 2004) such that only the strongest inputs are sent forward (Toan and Schultz 1985).…”

Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning

“…In contrast, dopamine neurons shift their activity from reward presentation to the associated cue as animals learn [11,12]. The release of dopamine in the striatum is known to enhance dSPN activity through D1 receptors [22,23], a step thought to enhance the likelihood of action initiation [7,24,25]. While our findings are consistent with these models, they further reveal that VS dSPNs are specifically responsive to actions that fulfill the learned CS-reward association.…”

Dysregulation of brain dopamine systems in major depressive disorder

“…20 D1-like receptor activation can contribute to either excitation or inhibition, dependent on cell type; D2-like receptor activation is usually inhibitory. [21][22][23] DA signaling is typically terminated by re-uptake of DA through a high-affinity presynaptic transporter (DAT).…”

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

“…DA modulates MSN firing (Cepeda et al 1993;Hernandez-Lopez et al 1997;Surmeier 2006) as well as facilitates changes in synaptic efficacy in the striatum (Calabresi et al 1992;Stefani et al 1995;Schultz 1998;Shen et al 2008). DA likely also filters cortico-basal ganglia input (Rolls et al 1984;Bamford et al 2004) such that only the strongest inputs are sent forward (Toan and Schultz 1985).…”

Direct Pathway Neurons in the Mouse Ventral Striatum Are Active During Goal-Directed Action but Not Reward Consumption During Operant Conditioning

“…In contrast, dopamine neurons shift their activity from reward presentation to the associated cue as animals learn [11,12]. The release of dopamine in the striatum is known to enhance dSPN activity through D1 receptors [22,23], a step thought to enhance the likelihood of action initiation [7,24,25]. While our findings are consistent with these models, they further reveal that VS dSPNs are specifically responsive to actions that fulfill the learned CS-reward association.…”

Dysregulation of brain dopamine systems in major depressive disorder

“…20 D1-like receptor activation can contribute to either excitation or inhibition, dependent on cell type; D2-like receptor activation is usually inhibitory. [21][22][23] DA signaling is typically terminated by re-uptake of DA through a high-affinity presynaptic transporter (DAT).…”

Cortico-basal ganglia circuitry: a review of key research and implications for functional connectivity studies of mood and anxiety disorders

“…DA modulates MSN firing (Cepeda et al 1993;Hernandez-Lopez et al 1997;Surmeier 2006) as well as facilitates changes in synaptic efficacy in the striatum (Calabresi et al 1992;Stefani et al 1995;Schultz 1998;Shen et al 2008). DA likely also filters cortico-basal ganglia input (Rolls et al 1984;Bamford et al 2004) such that only the strongest inputs are sent forward (Toan and Schultz 1985).…”