Electrophysiological properties of nigrothalamic neurons after 6-hydroxydopamine lesions in the rat

Macleod, Neil; Ryman, Ann; Arbuthnott, G.W.

doi:10.1016/0306-4522(90)90041-2

Cited by 71 publications

(65 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Firing rates of neurons recorded in the SNpr of the two preparations were not significantly different (Table 1), despite the marked difference in firing pattern after dopamine loss. These observations are consistent with a number of studies showing increased burstiness or oscillatory activity in the SNpr 2-8 weeks after dopamine cell lesion in anesthetized rats (Sanderson et al, 1986;MacLeod et al, 1990;Burbaud et al, 1995;Murer et al, 1997;Rohlfs et al, 1997;Tseng et al, 2000Tseng et al, ,2001aBelluscio et al, 2003).…”

Section: Snpr Spike Train Firing Patterns and Spike-lfp Phase Relatiosupporting

confidence: 92%

“…Mean firing rates were significantly increased in the STN and the striatum but not significantly altered in the GP and SNpr at this post lesion time point. In general, the firing pattern changes observed are consistent with previous reports of alterations in individual basal ganglia nuclei in anesthetized, dopamine-depleted preparations at time periods 1-10 weeks after lesion (Sanderson et al, 1986;MacLeod et al, 1990;Hollerman and Grace, 1992;Burbaud et al, 1995;Hassani et al, 1996;Murer et al, 1997;Rohlfs et al, 1997;Magill et al, 2000Magill et al, , 2001Ni et al, 2000aNi et al, , 2001Tseng et al, 2000Tseng et al, , 2001aVila et al, 2000;Belluscio et al, 2003;Tai et al, 2003). It is interesting to note that dopamine receptor antagonist-induced reductions in dopamine receptor stimulation also induce changes in firing pattern in basal ganglia output nuclei in anesthetized rats (Degos et al, 2005).…”

Section: Firing Patterns In the Basal Ganglia Network After Dopamine supporting

confidence: 90%

“…In addition, they provide an opportunity to examine relationships between interconnected nuclei to gain insight into the extent to which firing pattern changes in individual nuclei are linked to broader changes engaging the entire basal ganglia network. In one commonly used animal model of PD, the anesthetized rodent with a unilateral 6-hydroxydopamine (6-OHDA)-induced medial forebrain bundle lesion, a number of studies have found that firing patterns in STN and SNpr become more bursty (Sanderson et al, 1986;MacLeod et al, 1990;Hollerman and Grace, 1992;Burbaud et al, 1995;Hassani et al, 1996;Murer et al, 1997;Rohlfs et al, 1997;Tseng et al, 2000Tseng et al, , 2001aVila et al, 2000;Magill et al, 2001;Ni et al, 2001;Belluscio et al, 2003;Tai et al, 2003). This bursty activity has been shown to be correlated with slow oscillations in cortical EEG (Magill et al, 2001;Tseng et al, 2001b;Belluscio et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

et al. 2007

View full text Add to dashboard Cite

The goal of the present study was to determine the phase relationships of the slow oscillatory activity that emerges in basal ganglia nuclei in anesthetized rats after dopamine cell lesion in order to gain insight into the passage of this oscillatory activity through the basal ganglia network. Spike train recordings from striatum, subthalamic nucleus (STN), globus pallidus (GP), and substantia nigra pars reticulata (SNpr) were paired with simultaneous local field potential (LFP) recordings from SNpr or motor cortex ipsilateral to a unilateral lesion of substantia nigra dopamine neurons in urethane anesthetized rats. Dopamine cell lesion induced a striking increase in incidence of slow oscillations (0.3-2.5 Hz) in firing rate in all nuclei. Phase relationships assessed through paired recordings using SNpr LFP as a temporal reference showed that slow oscillatory activity in GP spike trains is predominantly antiphase with oscillations in striatum, and slow oscillatory activity in STN spike trains is in-phase with oscillatory activity in cortex but predominantly antiphase with GP oscillatory activity. Taken together, these results imply that after dopamine cell lesion in urethane anesthetized rats, increased oscillatory activity in GP spike trains is shaped more by increased phasic inhibitory input from the striatum than by phasic excitatory input from STN. In addition, results show that oscillatory activity in SNpr spike trains is typically antiphase with GP oscillatory activity and in-phase with STN oscillatory activity. While these observations do not rule out additional mechanisms contributing to the emergence of slow oscillations in the basal ganglia after dopamine cell lesion in the anesthetized preparation, they are compatible with 1) increased oscillatory activity in the GP facilitated by an effect of dopamine loss on striatal 'filtering' of slow components of oscillatory cortical input, 2) increased oscillatory activity in STN spike trains supported by convergent antiphase inhibitory and excitatory oscillatory input from GP and cortex, respectively, and 3) increased oscillatory activity in SNpr spike trains organized by convergent antiphase inhibitory and excitatory oscillatory input from GP and STN, respectively. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errorsmaybe discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeuroscience. Author manuscript; available in PMC 2012 May 17. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript KeywordsParkinson's disease; subthalamic nucleus; substantia nigra; globus pallidus; striatum; bursting; local field potentials Dopa...

show abstract

Section: Snpr Spike Train Firing Patterns and Spike-lfp Phase Relatiosupporting

confidence: 92%

Section: Firing Patterns In the Basal Ganglia Network After Dopamine supporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

et al. 2007

View full text Add to dashboard Cite

show abstract

“…DA suppresses slow firing oscillations and regular bursting of BG neurons (∼ 1 Hz) in anaesthesized and sleeping rats (Pan & Walters, 1988;MacLeod et al, 1990;Murer et al, 1997;Tseng et al, 2000;. Since rhythmic bursts have been interpreted as the result of spreading of cortical activity into BG nuclei, these changes may reflect a barrier between cortex and BG.…”

Section: Da Modulation Of Global Field Dynamicsmentioning

confidence: 99%

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Alcaro

Huber

Panksepp

2007

Brain Research Reviews

514

294

View full text Add to dashboard Cite

The mesolimbic dopaminergic (ML-DA) system has been recognized for its central role in motivated behaviors, various types of reward, and, more recently, in cognitive processes. Functional theories have emphasized DA's involvement in the orchestration of goal-directed behaviors, and in the promotion and reinforcement of learning. The affective neuroethological perspective presented here, views the ML-DA system in terms of its ability to activate an instinctual emotional appetitive state (SEEKING) evolved to induce organisms to search for all varieties of life-supporting stimuli and to avoid harms.A description of the anatomical framework in which the ML system is embedded is followed by the argument that the SEEKING disposition emerges through functional integration of ventral basal ganglia (BG) into thalamocortical activities. Filtering cortical and limbic input that spread into BG, DA transmission promotes the "release" of neural activity patterns that induce active SEEKING behaviors when expressed at the motor level. Reverberation of these patterns constitutes a neurodynamic process for the inclusion of cognitive and perceptual representations within the extended networks of the SEEKING urge. In this way, the SEEKING disposition influences attention, incentive salience, associative learning, and anticipatory predictions.In our view, the rewarding properties of drugs of abuse are, in part, caused by the activation of the SEEKING disposition, ranging from appetitive drive to persistent craving depending on the intensity of the affect. The implications of such a view for understanding addiction are considered, with particular emphasis on factors predisposing individuals to develop compulsive drug seeking behaviors.

show abstract

“…Cortical activity in the urethane-anesthetised rat is highly synchronized, characteristically oscillates at ∼1Hz, and is relatively stable over time (Steriade et al, 1993;Steriade, 1995, 1997;Amzica and Steriade, 1998). Many studies have shown changes in firing pattern and increased oscillatory activity in the basal ganglia following dopamine cell lesion in the anesthetized rat (Sanderson et al, 1986;MacLeod et al, 1990;Hollerman and Grace, 1992;Burbaud et al, 1995;Hassani et al, 1996;Murer et al, 1997;Rohlfs et al, 1997;Tseng et al, 2000Tseng et al, , 2001aTseng et al, , 2001bPerier et al, 2000;Vila et al, 2000;Magill et al, 2001;Ni et al, 2001;Belluscio et al, 2003;Tai et al, 2003;Walters et al, 2005Walters et al, , 2007Parr-Brownlie et al, 2007;Zold et al, 2007). Recently, this cortical oscillatory activity has been used as a probe signal in the urethane-anesthetized rat to investigate the effects of dopamine loss on the phase relationships between oscillatory activity in the external segment of the globus pallidus (GPe), the substantia nigra pars reticulata (SNpr), the subthalamic nucleus (STN), and the striatum .…”

Section: Introductionmentioning

confidence: 99%

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Aravamuthan

Bergstrom

French

et al. 2008

Experimental Neurology

View full text Add to dashboard Cite

The pedunculopontine nucleus (PPN) is a new deep brain stimulation (DBS) target for Parkinson's disease (PD), but little is known about PPN firing pattern alterations in PD. The anesthetized rat is a useful model for investigating the effects of dopamine loss on the transmission of oscillatory cortical activity through basal ganglia structures. After dopamine loss, synchronous oscillatory activity emerges in the subthalamic nucleus and substantia nigra pars reticulata in phase with cortical slow oscillations. To investigate the impact of dopamine cell lesion-induced changes in basal ganglia output on activity in the PPN, this study examines PPN spike timing with reference to motor cortex (MCx) local field potential (LFP) activity in urethane-and ketamine-anesthetized rats. Seven -ten days after unilateral 6-hydroxydopamine lesion of the medial forebrain bundle, spectral power in PPN spike trains and coherence between PPN spiking and PPN LFP activity increased in the ∼1 Hz range in urethane-anesthetized rats. PPN spike timing also changed from firing predominantly in-phase with MCx slow oscillations in the intact urethane-anesthetized rat to firing predominantly antiphase to MCx oscillations in the hemi-parkinsonian rat. These changes were not observed in the ketamine-anesthetized preparation. These observations suggest that dopamine loss alters PPN spike timing by increasing inhibitory oscillatory input to the PPN from basal ganglia output nuclei, a phenomenon that may be relevant to motor dysfunction and PPN DBS efficacy in PD patients.

show abstract

Electrophysiological properties of nigrothalamic neurons after 6-hydroxydopamine lesions in the rat

Cited by 71 publications

References 52 publications

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

Behavioral functions of the mesolimbic dopaminergic system: An affective neuroethological perspective

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Contact Info

Product

Resources

About