Electrophysiological properties of intralaminar thalamocortical cells discharging rhythmic (≈40 HZ) spike-bursts at ≈1000 HZ during waking and rapid eye movement sleep

Steriade, Mircea; Dossi, R. Curró; Contreras, Diego

doi:10.1016/0306-4522(93)90556-u

Cited by 233 publications

(154 citation statements)

References 15 publications

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“…A comparison of the firing properties of Pf cells at −60 mV and −80 mV indicated that the majority of cells failed to display significant changes in firing properties. None of the cells displayed rhythmic LTS-like burst firing, such as that underlying slow oscillations in thalamic neurons triggered by hyperpolarizing current pulses or occurring spontaneously (Steriade et al, 1993), at any membrane potential. The slow membrane oscillations that are common in thalamic relay neurons (Steriade et al, 1993) were present in only a few Pf cells (Fig.…”

Section: Voltage-dependent Firing Patterns Of Pf Cellsmentioning

confidence: 99%

“…Not surprisingly, therefore, none of our Pf cells displayed repetitive slow oscillations and they lacked the prominent plateau potentials that characterize classic thalamic relay neurons (Jahnsen and Llinas, 1984a;Jahnsen and Llinas, 1984b;Jahnsen and Llinas, 1984c). This indicates that cells in Pf have different firing properties than cells in neighboring regions of the intralaminar thalamus that do express rhythmic high frequency bursting behaviors (Steriade et al, 1993).…”

Section: Lack Of Bipotential Firing In Pf Cellsmentioning

confidence: 99%

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Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

Phelan

Mahler

Deere

et al. 2005

THL

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Thalamic relay neurons have homogeneous, adult-like firing properties and similar morphology by 12 days postnatally (PN 12). Parafascicular (Pf) neurons have a different morphology compared with typical thalamic relay neurons, but the development of their electrophysiological properties is not well studied. Intracellular recordings in PN 12-50 Pf neurons revealed several heterogeneous firing patterns different from those in thalamic relay neurons. Two types of cells were identified: Type I cells displayed a fast afterhyperpolarization (AHP) followed by a large-amplitude, slow AHP; whereas Type II cells had only a fast AHP. These cell types had overlapping membrane properties but differences in excitability. Some properties of Pf neurons were adult-like by PN 12, but, unlike thalamic relay neurons, there were significant maturational changes thereafter, including decreased action potential (AP) duration, increased fast AHP amplitude and increased excitability. Pf neurons did not exhibit rhythmic bursting and generally lacked low-threshold spike (LTS) responses that characterize thalamic relay neurons. Pf neurons exhibited nonlinear I-V relationships, and only a third of the cells expressed the time and voltage-dependent hyperpolarization activated (Ih) current, which declined with age. These results indicate that the morphological differences between Pf neurons and typical thalamic relay neurons are paralleled by electrophysiological differences, and that Pf membrane properties change during postnatal development.

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Section: Voltage-dependent Firing Patterns Of Pf Cellsmentioning

confidence: 99%

Section: Lack Of Bipotential Firing In Pf Cellsmentioning

confidence: 99%

Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

Phelan

Mahler

Deere

et al. 2005

THL

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“…GAMMA OSCILLATIONS-Several types of cortical (Llinás et al, 1991;Nuñez et al, 1992) and thalamic neurons (Steriade et al, 1991b;Steriade et al, 1993c) display either fast subthreshold resonance or act as bone fide high frequency pacemakers (Gray and McCormick, 1996). Mutually coupled networks of interneurons are sufficient to produce gamma oscillations under certain circumstances (30-90 Hz) in cortical circuits Wang and Buzsáki, 1996;Traub et al, 1999;Bartos et al, 2002).…”

Section: Slow (<1 Hz) Rhythms-mirceamentioning

confidence: 99%

Interaction between neocortical and hippocampal networks via slow oscillations

Sirota

Buzsáki

2005

THL

230

219

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Both the thalamocortical and limbic systems generate a variety of brain state-dependent rhythms but the relationship between the oscillatory families is not well understood. Transfer of information across structures can be controlled by the offset oscillations. We suggest that slow oscillation of the neocortex, which was discovered by Mircea Steriade, temporally coordinates the self-organized oscillations in the neocortex, entorhinal cortex, subiculum and hippocampus. Transient coupling between rhythms can guide bidirectional information transfer among these structures and might serve to consolidate memory traces.

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“…Phase resets of this system have been proposed to underlie magnetoencephalographic signatures of cognitive binding processes identified during auditory discrimination experiments (Joliot et al, 1994). Steriade et al (1993Steriade et al ( , 1996 have simultaneously recorded intralaminar thalamic and cortical neurons with synchronous firing in these high-frequency ranges.…”

Section: Physiologic Evidence Of Cerebral Gating Processesmentioning

confidence: 99%

The Role of Arousal and “Gating” Systems in the Neurology of Impaired Consciousness

Schiff

Plum

2000

Journal of Clinical Neurophysiology

161

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Summary:A brief taxonomy of neurologic disorders resulting in global impairments of consciousness is presented. Particular emphasis is placed on focal injuries of subcortical structures that may produce disorders that are otherwise associated to large bilateral cortical injuries. A distinction between subcortical arousal and "gating" systems is developed. Both clinical and experimental studies are reviewed in the context of these disorders and their possible underlying mechanisms. Key Words: Awareness-Persistent vegetative state-Intralaminar thalamic nuclei-Akinetic mutism-Reticular formation.Understanding the disorders of human consciousness provides an empirical first step toward understanding mechanisms underlying human awareness. The neurologist's view of consciousness is derived from reliable observations of brain structure and function that lead to implicit hypotheses. These hypotheses represent implied models that may be examined in light of many recent advances in clinical and experimental neuroscience. Impaired consciousness of a variety of kinds may result from focal brain injuries that induce widespread functional changes. Differences in the clinical features of these human disabilities illustrate the interdependent relationships of brain mechanisms underlying arousal, gating, and expression of several specific neuropsychologic traits. In many cases, brain damage is too severe to permit meaningful recovery, as exemplified by the vegetative state. In others, transient or permanent behavioral abnormalities precipitated by focal lesions may reveal the contribution of specific brain systems to the overall conscious state. Global disorders of consciousness include stupor and coma, vegetative states, akinetic mutism, absence and partial complex seizures, hyperkinetic mutism, and others. These disturbances can be acute, and relatively brief, or may persist as protracted states. The authors explore the neurology of impaired consciousness, developing a brief taxonomy of global disorders of consciousness, and placing these neurologic diseases in the context of the underlying anatomy and physiology of arousal and "gating" systems. Definition of consciousness: A definition closely following that of James (1890) is offered for the psychological dimension of consciousness:At its least, normal human consciousness consists of a serially time-ordered, organized, restricted and reflective awareness of self and the environment. Moreover, it is an experience of graded complexity and quantity.

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Electrophysiological properties of intralaminar thalamocortical cells discharging rhythmic (≈40 HZ) spike-bursts at ≈1000 HZ during waking and rapid eye movement sleep

Cited by 233 publications

References 15 publications

Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

Postnatal maturational properties of rat parafascicular thalamic neurons recorded in vitro

Interaction between neocortical and hippocampal networks via slow oscillations

The Role of Arousal and “Gating” Systems in the Neurology of Impaired Consciousness

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