Electrophysiological connectivity measures from deep brain stimulation (DBS)-targets in Parkinson’s disease and dystonia

Lofredi, Roxanne; Kühn, Andrea A.

doi:10.1016/b978-0-12-821861-7.00007-5

Cited by 2 publications

(1 citation statement)

References 83 publications

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“…Intracerebral recordings from patients undergoing deep brain stimulation (DBS) surgery for Parkinson' disease (PD) have revealed increased subthalamic oscillatory beta band activity as a pathophysiological hallmark of the PD motor state [1][2][3][4][5][6] . Both dopaminergic medication as well as DBS are associated with a decrease of this pathologically enhanced activity, specifically in the low beta sub-band (LB=13-20 Hz), which has primarily been related to bradykinetic-rigid symptoms [7][8][9][10][11][12] .…”

Section: Introductionmentioning

confidence: 99%

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Lofredi

Okudzhava

Irmen

et al. 2022

Preprint

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Background: Pathologically increased beta power has been described as a biomarker for Parkinsons disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Methods: Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinsons patients in the ON- and OFF- medication state, suing two different methods of beta burst determination. Results: We report a frequency-specific correlation of low beta power and burst duration with motor impairment OFF dopaminergic medication. Furthermore, reduction of power and burst duration correlated significantly with symptom alleviation through dopaminergic medication. Importantly, qualitatively similar results were yielded with two different methods of beta burst definition. Conclusions: Our findings validate the robustness of previous results on pathological changes in subcortical oscillations both in the frequency- as well as in the time-domain in the largest cohort of PD patients to date with important implications for next-generation adaptive deep brain stimulation control algorithms.

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Section: Introductionmentioning

confidence: 99%

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Lofredi

Okudzhava

Irmen

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Lofredi

Okudzhava

Irmen

et al. 2023

npj Parkinsons Dis.

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View full text Add to dashboard Cite

Pathologically increased beta power has been described as a biomarker for Parkinson’s disease (PD) and related to prolonged bursts of subthalamic beta synchronization. Here, we investigate the association between subthalamic beta dynamics and motor impairment in a cohort of 106 Parkinson’s patients in the ON- and OFF-medication state, using two different methods of beta burst determination. We report a frequency-specific correlation of low beta power and burst duration with motor impairment OFF dopaminergic medication. Furthermore, reduction of power and burst duration correlated significantly with symptom alleviation through dopaminergic medication. Importantly, qualitatively similar results were yielded with two different methods of beta burst definition. Our findings validate the robustness of previous results on pathological changes in subcortical oscillations both in the frequency- as well as in the time-domain in the largest cohort of PD patients to date with important implications for next-generation adaptive deep brain stimulation control algorithms.

show abstract

Electrophysiological connectivity measures from deep brain stimulation (DBS)-targets in Parkinson’s disease and dystonia

Cited by 2 publications

References 83 publications

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

Subthalamic beta bursts correlate with dopamine-dependent motor symptoms in 106 Parkinson’s patients

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