Electrophysiologic effects of intravenous dipyridamole

Bubiński, R; Markiewicz, K; M, Cholewa; Górski, L; Gawor, Z; Kuś, Włodzimierz

doi:10.1016/0167-5273(89)90012-0

Cited by 14 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These actions include prolongation of intra-atrial and atrioventricular conduction, without prolongation of the QTc interval [11]. Shortening of the atrial action potential and hyperpolarisation of atrial cells also occurs as a result of increased potassium conductance [12].…”

Section: Discussionmentioning

confidence: 99%

“…This possibility is supported by the significant sinus bradycardia during the adenosine infusion. This response occurs in sino-atrial disease with dipyridamole [11], which exerts its effects by increasing interstitial levels of adenosine [13], and asystole has been recorded following oral dipyridamole for thallium imaging [14]. There is also evidence that intravenous adenosine exerts a marked bradycardic effect in patients with sino-atrial disease, and cycle lengths of greater than 11 s have been recorded in such patients [15].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Bradycardia progressing to cardiac arrest during adenosine thallium myocardial perfusion imaging in occult sino-atrial disease

et al. 1994

View full text Add to dashboard Cite

Adenosine is used increasingly as an alternative to dynamic exercise during myocardial perfusion imaging because it is a powerful coronary vasodilator with a short half-life. Minor side-effects are common but life-threatening events are rare. We report two cases of provocation by adenosine infusion of profound sinus bradycardia progressing to atrial and ventricular asystole. Despite discontinuation of the infusion, asystole persisted for up to 1 min in one case and was accompanied by a grand mal seizure. Normal sinus rhythm returned spontaneously in both cases without long-term sequelae. Sino-atrial disease was later suggested in both cases by 24-h electrocardiographic monitoring. We conclude that patients to whom adenosine is given may have occult sino-atrial disease and may be susceptible to life-threatening arrhythmias. Significant sinus bradycardia during the infusion may provide a warning of its presence.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bradycardia progressing to cardiac arrest during adenosine thallium myocardial perfusion imaging in occult sino-atrial disease

et al. 1994

View full text Add to dashboard Cite

show abstract

“…Activation of K + channels hyperpolarises supraventricular tissue and shortens the duration of the atrial action potential (Belardinelli and Isenberg 1983). In addition, adenosine also prolongs intra-atrial conduction times (Bubinski et al 1989). These effects are thought to be important in the occasional cases of induction by adenosine of atrial flutter (DiMarco et al 1985;Lerman et al 1989).…”

Section: Electrophysiological Effects Of Dipyridamole On the Atriummentioning

confidence: 99%

Atrial fibrillation after intravenous dipyridamole for thallium imaging

Pennell

Ell

1992

Eur J Nucl Med

View full text Add to dashboard Cite

Dipyridamole 0.56 mg/kg was administered intravenously for thallium tomography after myocardial infarction. Fast atrial fibrillation developed which failed to resolve with aminophylline. Sinus rhythm returned within 3 days. Myocardial tomography revealed apical infarction without reversible ischaemia. Atrial fibrillation after dipyridamole is rare and may be caused by direct electrophysiological effects on the atrial myocardium.

show abstract

Section: Introductionmentioning

confidence: 99%

“…[2] While electrophysiologic effects of adenosine and dipyridamole at the atrial and atrioventricular (AV) node have been fully demonstrated, their effects on His-Purkinje conduction have not been reported. [3,4] We describe two patients exhibiting intermittent left bundle branch block (LBBB) during dipyridamole intravenous infusion. At 1 year of follow-up, both patients developed permanent LBBB.…”

Section: Introductionmentioning

confidence: 99%

Unusual dipyridamole-induced aberrant conduction in the absence of myocardial ischemia

Ricca-Mallada¹,

Ferrando-Castagnetto

Ferrando

et al. 2017

World J Nucl Med

View full text Add to dashboard Cite

We report two patients referred to 2 day stress-rest single photon emission computed tomography for diagnosis of ischemia who elicited a transient left bundle branch block during dipyridamole intravenous infusion. The conduction disturbance disappeared after aminophyline infusion and became permanent during follow-up. Possible mechanisms underlying this unusual phenomenon in the absence of myocardial ischemia are discussed.

show abstract

Electrophysiologic effects of intravenous dipyridamole

Cited by 14 publications

References 34 publications

Bradycardia progressing to cardiac arrest during adenosine thallium myocardial perfusion imaging in occult sino-atrial disease

Bradycardia progressing to cardiac arrest during adenosine thallium myocardial perfusion imaging in occult sino-atrial disease

Atrial fibrillation after intravenous dipyridamole for thallium imaging

Unusual dipyridamole-induced aberrant conduction in the absence of myocardial ischemia

Contact Info

Product

Resources

About