Electroencephalography in acute stroke

Синкин, М. В.; Kaimovsky, I.; Komoltsev, Ilia; Трифонов, И. С.; Shtekleyn, A A; Guekht, Alla

doi:10.17116/jnevro202012008210

Cited by 6 publications

(1 citation statement)

References 23 publications

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“…Although interictal spikes normally indicate epileptic events, they are not a consistent biomarker for the development of chronic epilepsy. Other severe neurological conditions, such as stroke also shared the similar patterns of interictal spikes ( 70 , 71 ). Our study duration was 4 weeks and omitted animals that had only been observed with IEDs but not seizures.…”

Section: Discussionmentioning

confidence: 89%

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

Zhu

Wang

et al. 2023

Front. Neurol.

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ObjectiveTo test the feasibility and reliability of intracranial electrophysiological recordings in an acute status epilepticus model on laboratory swine.MethodIntrahippocampal injection of kainic acid (KA) was performed on 17 male Bama pigs (Sus scrofa domestica) weighing between 25 and 35 kg. Two stereoelectroencephalography (SEEG) electrodes with a total of 16 channels were implanted bilaterally along the sensorimotor cortex to the hippocampus. Brain electrical activity was recorded 2 h daily for 9–28 days. Three KA dosages were tested to evaluate the quantities capable of evoking status epilepticus. Local field potentials (LFPs) were recorded and compared before and after the KA injection. We quantified the epileptic patterns, including the interictal spikes, seizures, and high-frequency oscillations (HFOs), up to 4 weeks after the KA injection. Test–retest reliability using intraclass correlation coefficients (ICCs) were performed on interictal HFO rates to evaluate the recording stability of this model.ResultsThe KA dosage test suggested that a 10 μl (1.0 μg/μl) intrahippocampal injection could successfully evoke status epilepticus lasting from 4 to 12 h. At this dosage, eight pigs (50% of total) had prolonged epileptic events (tonic-chronic seizures + interictal spikes n = 5, interictal spikes alone n = 3) in the later 4 weeks of the video-SEEG recording period. Four pigs (25% of total) had no epileptic activities, and another four (25%) had lost the cap or did not complete the experiments. Animals that showed epileptiform events were grouped as E + (n = 8) and the four animals showing no signs of epileptic events were grouped as E– (n = 4). A total of 46 electrophysiological seizures were captured in the 4-week post-KA period from 4 E + animals, with the earliest onset on day 9. The seizure durations ranged from 12 to 45 s. A significant increase of hippocampal HFOs rate (num/min) was observed in the E+ group during the post-KA period (weeks 1, 2,4, p < 0.05) compared to the baseline. But the E-showed no change or a decrease (in week 2, p = 0.43) compared to their baseline rate. The between-group comparison showed much higher HFO rates in E + vs. E – (F = 35, p < 0.01). The high ICC value [ICC (1, k) = 0.81, p < 0.05] quantified from the HFO rate suggested that this model had a stable measurement of HFOs during the four-week post-KA periods.SignificanceThis study measured intracranial electrophysiological activity in a swine model of KA-induced mesial temporal lobe epilepsy (mTLE). Using the clinical SEEG electrode, we distinguished abnormal EEG patterns in the swine brain. The high test–retest reliability of HFO rates in the post-KA period suggests the utility of this model for studying mechanisms of epileptogenesis. The use of swine may provide satisfactory translational value for clinical epilepsy research.

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Section: Discussionmentioning

confidence: 89%

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

Zhu

Wang

et al. 2023

Front. Neurol.

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Abnormal EEG Background Activity

Wang

Yan

2021

Multi-Modal EEG Monitoring of Severely Neurologically Ill Patients

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Intraoperative neurophysiological monitoring in patients with delayed cerebral ischemia after clipping of ruptured arterial aneurysms

Bobriakov,

Petrov,

Sereda

et al. 2024

Nejrohirurgiâ (Mosk.)

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Aim. Research of significant changes in parameters (SCP) by intraoperative neurophysiological monitoring (IONM) during clipping of ruptured cerebral aneurysms in patients with delayed cerebral ischemia (DCI) in the postoperative period.Materials and methods. The study included 16 patients, 7 (43.8 %) men and 9 (56.2 %) women, aged 51.1 ± 9.3 years, who underwent clipping of ruptured cerebral aneurysms for the period 2016–2021, in which the neurological deficit (ND) remained at the preoperative level on the first postoperative day, but increased by the end of hospitalization. In order to study the factors leading to the development of DCI, 2 groups were identified with transient SCP according to IONM: with the development of DCI – 7 patients out of the above 16 patients, including 3 men (42.9 %) and 4 women (57.1 %), aged 49.6 ± 8.5 years; and control group – 19 patients, including 9 men (47.4 %) and 10 women (52.6 %), aged 46.2 ± 10.9 years, in whom ND did not increase on the first postoperative day and by the time of discharge. The groups did not differ significantly in age, sex, aneurysm location, rupture period, and baseline ND.Results. In patients with DCI, in 9 cases (56.2 %), during the operation, SCP from the side of somatosensory evoked potentials (SSEP) and transcranial motor evoked potentials (TcMEP) was not registered, in 7 cases (43.8 %) transient SCP was registered, of which 3 patients (42.8 %) had TcMEP and SSEP, in 2 patients (28.6 %) – only TcMEP and in 2 patients (28.6 %) – only SSEP. In the control group, transient SCR of TcMEPs and SSEPs were registered in 4 patients (21.6 %), only TcMEPs – in 9 patients (47.4 %), only SSEPs – in 6 patients (31.6 %). When comparing two groups of patients with transient SCR (DCI‑group and control group), a statistically significant predominance was revealed in the first group of patients with severity 3 according to the Hunt–Hess scale (42.9 % vs 5.2 %), while in the second group patients of severity 1 and 2 prevailed (94.8 % vs 57.2 %) (p <0.05). When analyzing the data of ultrasonic duplex scanning of extra- and intracranial arteries in both groups, a statistically significant increase in peak systolic blood flow velocity in the middle cerebral artery was revealed (in the group with DCI before surgery – 100 (80–139) cm/s, after surgery – 175 (139–278) cm/s (p = 0.001), in the control group before surgery – 100 (100–118) cm/s, after surgery – 150 (116–194) cm/s (p = 0.0001)), as well as the Lindegaard index (in the group with DCI before surgery – 2.5 ± 0.7, after surgery – 3.5 ± 1.1 (p = 0.01), in the control group before surgery – 2.1 ± 0.3, after surgery 2.9 ± 1.1 (p = 0.0002)), but the differences between the groups were not statistically significant (p = 0.092).Conclusion. At this stage, it cannot be unequivocally stated that transient SCP according to IONM may be one of the risk factors for the development of DCI after clipping of ruptured cerebral aneurysms. However, patients with transient SCR according to IONM, whose severity at admission is estimated at 3 points on the Hunt–Hess scale, are statistically significantly more likely to develop DCI.

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Electroencephalography in acute stroke

Cited by 6 publications

References 23 publications

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

Intracranial electrophysiological recordings on a swine model of mesial temporal lobe epilepsy

Abnormal EEG Background Activity

Intraoperative neurophysiological monitoring in patients with delayed cerebral ischemia after clipping of ruptured arterial aneurysms

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