Electrodeless Electrohydrodynamic Drop-on-Demand Encapsulation of Drugs into Porous Polymer Films for Fabrication of Personalized Dosage Units

Personalised dosing: Printing a dose of one’s own medicine

“…The concept has been developed into technology that can dispense continuous streams of droplets, known as continuous ink-jetting (CIJ) (Priest et al, 1997). An alternative method is drop-on-demand (DOD) ejection of droplets (Wang and Bokor, 2007), which produces precise droplets at high speeds when needed (Elele et al, 2012). Due to its relative simplicity, lower cost and high precision, DOD printing is favoured over continuous ink-jet printing in desktop printer markets, and it is the technology that is most often used in printing applications (Le, 1999;Pond, 1996;Jang et al, 2009).…”

“…The colour was used to visualise the deposited solution and might be used to quantify the dose deposited. An alternative suggestion is the use of gravimetry, as microbalances with high sensitivity can measure the weight of the substances deposited on the substrate (Elele et al, 2012).…”

Dropwise Additive Manufacturing of Pharmaceutical Products for Solvent-Based Dosage Forms

“…Because of the system's ability to print melt‐based systems and the noncontact nature of drug‐on‐demand, it can be used to print on a variety of sensitive substrates. In this work, we discuss printing only on edible polymeric films, but other DoD methods used to deposit drug systems have been shown to applicable on a variety of porous or nonporous films . DAMPP could also possibly be used to deposit material onto inert tablets, into capsules, or into micro‐sized wells to create granules.…”

Electro-Hydrodynamic Drop-on-Demand Printing of Aqueous Suspensions of Drug Nanoparticles

“…The use of the EHD DOD method for pharmaceutical applications was tested in [19] by printing polyethylene glycol (PEG), 400 solutions of poorly water-soluble ibuprofen (a non-steroidal anti-inflammatory drug), and griseofulvin (an antifungal drug) onto a porous hydroxypropyl methylcellulose (HPMC) film prepared by freeze-drying. Viscosities of these solutions exceeded the operating range of conventional inkjet print heads by a factor of 15-20.…”