Electrochemical sensors targeting salivary biomarkers: A comprehensive review

Mani, Veerappan; Bedük, Tutku; Khushaim, Walaa; Ceylan, Ayse Elcin; Tımur, Suna; Wolfbeis, Otto S.; Salama, Khaled N.

doi:10.1016/j.trac.2020.116164

Cited by 95 publications

(43 citation statements)

References 83 publications

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“…Paper is microscopic and hydrophilic, so it provides the basis for the formation of microscopic channels. They are used to diagnose urine metabolism, blood glucose, pH, liver function and infectious agents [30].…”

Section: Microfluidicsmentioning

confidence: 99%

The Salivary Secretome

Perpétuo¹,

Ferreira²,

Guedes³

et al. 2023

Periodontology - New Insights

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Recently, proteomics has emerged as an important tool for understanding biological systems, protein–protein interactions, and networks that ultimately lead to a deeper understanding of the underlying mechanisms of certain diseases. More recently, the study of secretomes, a type of proteomics, has also been highlighted as a potential next step in the field of diagnosis/prognosis. The secretome is the set of proteins expressed by an organism and secreted into the extracellular space, comprising 13–20% of all proteins. Since almost all, if not all, organs produce secretomes, this means that it is possible to study secretomes and trace these proteins back to their origin, supporting the idea that this could indeed be very important in diagnosing certain diseases. This is often combined with techniques such as mass spectrometry to measure the secretome of, for example, a particular tissue, and bioinformatics tools and databases to give us an idea of what to expect (prediction). In this paper, we will give a general overview of this world, but with a focus on the new bioinformatics tools and databases, their advantages and disadvantages, as well as a deeper look at isolation systems for proteomes, specifically salivary secretomes. Indeed, the salivary secretome represents a valuable new tool capable of providing insights into immunopathology and potentially aiding in diagnostics. Furthermore, we will explore applications of these methods and give an idea of what the future holds for such promising techniques: Salivary secretome in conjunction with bioinformatics tools/databases in the diagnosis of diseases (such as diabetes, Sjogren’s syndrome, and cardiovascular disease).

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Section: Microfluidicsmentioning

confidence: 99%

The Salivary Secretome

Perpétuo¹,

Ferreira²,

Guedes³

et al. 2023

Periodontology - New Insights

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“…Apart from blood, sweat ( Bariya et al, 2018 ), saliva ( Mani et al, 2021 ), tears ( Guo et al, 2021 ), interstitial fluid ( Kim et al, 2018 ),and urine ( Zhang et al, 2021a ) can also be indicators for diabetes as their chemistry is closely related to blood and thus all being the target for the point-of-care testing. Moreover, compared with blood, the collection of these body fluids does not need to destroy the stratum corneum so that is easier to achieve non-invasive and continuous detection of glucose.…”

Section: Biofluids Detectedmentioning

confidence: 99%

“…Furthermore, invasive collection hinders continuous monitoring of blood glucose ( Lee et al, 2018 ). Consequently, more research studies are toward sweat ( Bariya et al, 2018 ), saliva ( Mani et al, 2021 ), tears ( Guo et al, 2021 ), and interstitial fluid ( Kim et al, 2018 ) as alternatives to develop non-invasive, continuous, wearable, and point-of-care monitoring of glucose ( Yoon et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

The Application of Wearable Glucose Sensors in Point-of-Care Testing

Zhang

Zeng

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Diabetes and its complications have become a worldwide concern that influences human health negatively and even leads to death. The real-time and convenient glucose detection in biofluids is urgently needed. Traditional glucose testing is detecting glucose in blood and is invasive, which cannot be continuous and results in discomfort for the users. Consequently, wearable glucose sensors toward continuous point-of-care glucose testing in biofluids have attracted great attention, and the trend of glucose testing is from invasive to non-invasive. In this review, the wearable point-of-care glucose sensors for the detection of different biofluids including blood, sweat, saliva, tears, and interstitial fluid are discussed, and the future trend of development is prospected.

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“…VOC sensors and biosensors have emerged as alternatives to classic analytical tools mainly due to their faster response, cheaper analysis, and portable characteristics, while other features include enhanced selectivity, lower power consumption, or more rapid recovery times. VOC sensors and biosensors have been successfully employed in a large number of applications in food safety analysis, environmental monitoring, clinical analysis and medical diagnosis [ 63 , 64 , 65 , 66 ]; however, it must be highlighted that the majority of sensors and biosensors reported in previous years were developed without, or by poorly considering any green and sustainable characteristics of the final devices or of the production processes.…”

Section: Introductionmentioning

confidence: 99%

Paving the Way for a Green Transition in the Design of Sensors and Biosensors for the Detection of Volatile Organic Compounds (VOCs)

et al. 2022

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The efficient and selective detection of volatile organic compounds (VOCs) provides key information for various purposes ranging from the toxicological analysis of indoor/outdoor environments to the diagnosis of diseases or to the investigation of biological processes. In the last decade, different sensors and biosensors providing reliable, rapid, and economic responses in the detection of VOCs have been successfully conceived and applied in numerous practical cases; however, the global necessity of a sustainable development, has driven the design of devices for the detection of VOCs to greener methods. In this review, the most recent and innovative VOC sensors and biosensors with sustainable features are presented. The sensors are grouped into three of the main industrial sectors of daily life, including environmental analysis, highly important for toxicity issues, food packaging tools, especially aimed at avoiding the spoilage of meat and fish, and the diagnosis of diseases, crucial for the early detection of relevant pathological conditions such as cancer and diabetes. The research outcomes presented in the review underly the necessity of preparing sensors with higher efficiency, lower detection limits, improved selectivity, and enhanced sustainable characteristics to fully address the sustainable manufacturing of VOC sensors and biosensors.

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Electrochemical sensors targeting salivary biomarkers: A comprehensive review

Cited by 95 publications

References 83 publications

The Salivary Secretome

The Salivary Secretome

The Application of Wearable Glucose Sensors in Point-of-Care Testing

Paving the Way for a Green Transition in the Design of Sensors and Biosensors for the Detection of Volatile Organic Compounds (VOCs)

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