Electrochemical sensor for detection of cancer cell based on folic acid and octadecylamine-functionalized graphene aerogel microspheres

Ruiyi, Li; Cui, Fangchao; Zhu, Hao; Sun, Xiulan; Li, Zaijun

doi:10.1016/j.bios.2018.07.060

Cited by 56 publications

(24 citation statements)

References 26 publications

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“…The poly-L-lysine/GO-modified electrode has been utilized for the adhesion and detection of leukemia K562 cancer cells through the electrostatic interaction [140]. Li et al reported an electrochemical biosensor for the detection of cancer cells based on FA and octadecylamine-modified graphene aerogel microspheres [141]. As displayed in Figure 8B, GO sheets in the emulsion were self-assembled into graphene oxide gel microspheres on the water/toluene interfaces.…”

Section: Direct Detectionmentioning

confidence: 99%

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

2021

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The accurate analysis of circulating tumor cells (CTCs) holds great promise in early diagnosis and prognosis of cancers. However, the extremely low abundance of CTCs in peripheral blood samples limits the practical utility of the traditional methods for CTCs detection. Thus, novel and powerful strategies have been proposed for sensitive detection of CTCs. In particular, nanomaterials with exceptional physical and chemical properties have been used to fabricate cytosensors for amplifying the signal and enhancing the sensitivity. In this review, we summarize the recent development of nanomaterials-based optical and electrochemical analytical techniques for CTCs detection, including fluorescence, colorimetry, surface-enhanced Raman scattering, chemiluminescence, electrochemistry, electrochemiluminescence, photoelectrochemistry and so on.

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Section: Direct Detectionmentioning

confidence: 99%

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

2021

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“…The electrochemical test results showed a wide linear range of 50–2.0 × 10 6 cells/mL and a detection limit as low as 15 cells/mL. In another study, Li and colleagues demonstrated an electrochemical sensor based on folic acid (FA) and octadecylamine (OA)-functionalized graphene aerogel microspheres (FA-GAM-OA) for detection of HepG2 cells [ 47 ]. The FA-GAM-OA synthesized using the Pickering emulsion method differs from ordinary GO in that it consists of smaller graphene sheets.…”

Section: Electrochemical Detection Of Markers On Tumor Cellsmentioning

confidence: 99%

Electrochemical Sensors for Detection of Markers on Tumor Cells

Zhou

Zhang

2021

IJMS

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In recent years, the increasing incidence and mortality of cancer have inspired the development of accurate and rapid early diagnosis methods in order to successfully cure cancer; however, conventional methods used for detecting tumor cells, including histopathological and immunological methods, often involve complex operation processes, high analytical costs, and high false positive rates, in addition to requiring experienced personnel. With the rapid emergence of sensing techniques, electrochemical cytosensors have attracted wide attention in the field of tumor cell detection because of their advantages, such as their high sensitivity, simple equipment, and low cost. These cytosensors are not only able to differentiate tumor cells from normal cells, but can also allow targeted protein detection of tumor cells. In this review, the research achievements of various electrochemical cytosensors for tumor cell detection reported in the past five years are reviewed, including the structures, detection ranges, and detection limits of the cytosensors. Certain trends and prospects related to the electrochemical cytosensors are also discussed.

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“…The ordered alignment and covalent linkage of the folic acid groups at the FA-GAM-OA surface show strong affection with specific cancer and trap these cells with high capture efficiency. The electrochemical sensor based on FA-GAM-OA offers tremendous analytical performance, and it is helpful in the detection of liver cancer cells with a linear range of 5 to 105 cell mL -1 with a limit of detection of 5 cells mL -1 (S/N = 3) [76].…”

Section: Hydrogen Peroxide Sensormentioning

confidence: 99%

Aerogels for Sensor Application

Kumar

2021

Aerogels II

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Aerogels with air-filled pores and interconnected 3D solid networks show unique characteristics and, therefore, have tremendous applications in various fields. Integrating specific characteristics of aerogels, large surface area, low density, and high porosity are included which opens up possibilities for new application areas. Aerogels' advanced features provide high selectivity and sensitivity, fast recovery and response to sensing materials in sensors such as biosensors, gas, pressure, and strain sensors. In recent years significant work has been done regarding the development of aerogel-based sensors. In this chapter, recent challenges and some approaches to high-performance aerogel-based sensor development are summarized.

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Electrochemical sensor for detection of cancer cell based on folic acid and octadecylamine-functionalized graphene aerogel microspheres

Cited by 56 publications

References 26 publications

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

Recent Development of Nanomaterials-Based Cytosensors for the Detection of Circulating Tumor Cells

Electrochemical Sensors for Detection of Markers on Tumor Cells

Aerogels for Sensor Application

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