Electrochemical sensing with nanopores: A mini review

Makra, István; Gyurcsányi, Róbert E.

doi:10.1016/j.elecom.2014.03.007

Cited by 52 publications

(51 citation statements)

References 38 publications

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“…In electrochemical analysis, enhanced catalytic effect of nanoporous structures comes from its geometrical features, such as irregularity, large roughness and high porosity. Significant electrical signal amplification is supported by the nano-confinement effect, which allows increased probability for charge transfer between molecules and electrode surface [32,33]. It was reported that nanoporous gold coupled with several enzymes were able to show good sensing performance in detections of ethanol (with alcohol dehydrogenase (ADH)), hydrogen peroxide (with artificial peroxidase) and glucose (with glucose oxidase) [34].…”

Section: Introductionmentioning

confidence: 99%

Non-enzymatic amperometric detection of phenol and catechol using nanoporous gold

Quynh

Byun

Kim

2015

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Non-enzymatic amperometric detection of phenol and catechol using nanoporous gold

Quynh

Byun

Kim

2015

Sensors and Actuators B: Chemical

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“…Several excellent reviews have summarized the recent progress on single-entity analysis by using electrochemical techniques, [14][15][16][17][18][19][20][21][22][23] mainly focusing on strategies and methodologies for single-entity analysis, especially for hard particles. First, electrochemical experiments are conducted in solution, even in solutions with high salt concentrations, which can largely maintain the structures and properties of vesicles as in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Counting and Sizing of Single Vesicles/Liposomes by Electrochemical Events

Liu

et al. 2018

ChemElectroChem

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The analysis of single entities in a liquid phase by electrochemical events has received much attention in recent years due to innovations and advances in exciting electrochemical methods as well as precise manufacturing techniques. Vesicles, as a special type of entity, play an important role in biological systems. However, the soft character and complex surface chemistry of vesicles present inherent challenges for single‐vesicle analysis. This minireview mainly focuses on the theory and recent progress of single‐vesicle/liposome analysis based on electrochemical events. Three different analytical principles, namely, pore/channel translocation, microelectrode impact and nanopipette collision, are reviewed and expatiated. Not only the capabilities for size determination, vesicle/liposome counting and the electroactive quantification of the contents within vesicles/liposomes but also the specificities of vesicle/liposome or entity‐pore/electrode interactions reflected in translocation or collision events are discussed in detail. Moreover, the advantages and disadvantages of each method of single‐vesicle analysis are discussed in this minireview.

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“…With the ability to characterize a single particle, nanofluidic RPS is a strong candidate for resolving the technological gap of conventional nanoparticle analyses, e.g., nanoparticle‐tracking analysis and dynamic light scattering . Currently, two major obstacles in this technology are the extremely low particle‐to‐pore volume ratio (<0.01%) and short nanoparticle translocation time (10–1000 µs) . The magnitude of resistive pulses is proportional to the particle‐to‐pore volume ratio; therefore, an extremely small volume of nanoparticles causes the generation of a minute pulse that is difficult to detect .…”

Section: Introductionmentioning

confidence: 99%

Nanopore Sensing in Aqueous Two‐Phase System: Simultaneous Enhancement of Signal and Translocation Time via Conformal Coating

Lee

Kang

Choi

et al. 2016

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Nanofluidic resistive pulse sensing (RPS) has been extensively used to measure the size, concentration, and surface charge of nanoparticles in electrically conducting solutions. Although various methods have been explored for improving detection performances, intrinsic problems including the extremely low particle-to-pore volume ratio (<0.01%) and fast nanoparticle translocation (10-1000 µs) still induce difficulties in detection, such as low signal magnitudes and short translocation times. Herein, we present an aqueous two-phase system (ATPS) in a nanofluidic RPS for amplifying translocation signals and decreasing translocation speeds simultaneously. Two immiscible aqueous liquids build a liquid-liquid interface inside nanopores. As particles translocate from a high-affinity liquid phase into a lower-affinity one, the high-affinity liquid forms a conformal coating on the particles, which increases the effective particle size and amplifies the current-blockage signal. The translocation time is also increased, as the ATPS interface impedes the particle translocation. For 20 nm particles, 7.92-fold and 5.82-fold enhancements of signal magnitude and translocation time can be achieved. To our knowledge, this is the first attempt to improve nanofluidic RPS by treating an interface of solution reservoirs for manipulating target particles rather than nanopores. This direct particle manipulation allows us to solve the two intrinsic problems all at once.

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Electrochemical sensing with nanopores: A mini review

Abstract: 13We discuss representative electrochemical nanopore sensing strategies, highlighting their 14 underlying theoretical principles, and limitations.

Cited by 52 publications

References 38 publications

Non-enzymatic amperometric detection of phenol and catechol using nanoporous gold

Non-enzymatic amperometric detection of phenol and catechol using nanoporous gold

Counting and Sizing of Single Vesicles/Liposomes by Electrochemical Events

Nanopore Sensing in Aqueous Two‐Phase System: Simultaneous Enhancement of Signal and Translocation Time via Conformal Coating

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