Electrochemical sensing in paper-based microfluidic devices

Abstract

This paper describes the fabrication and the performance of microfluidic paper-based electrochemical sensing devices (we call the microfluidic paper-based electrochemical devices, μPEDs). The μPEDs comprise paper-based microfluidic channels patterned by photolithography or wax printing, and electrodes screen-printed from conducting inks (e.g., carbon or Ag/AgCl). We demonstrated that the μPEDs are capable of quantifying the concentrations of various analytes (e.g., heavy-metal ions and glucose) in aqueous solutions. This low-cost analytical device should be useful for applications in public health, environmental monitoring, and the developing world.

Paper-based electroanalytical devices with an integrated, stable reference electrode

“…Figure S3a demonstrates a linear relationship between the peak current, i p , at 0.19 V (vs. Ag/AgCl) and the concentration of K 3 [Fe(CN) 6 ] in the range of 1 to 10 mM (a typical range for cyclic voltammetry), in agreement with the Randles-Sevcik equation (eq S1).…”

Electrochemical biosensors based on nanomodified screen-printed electrodes: Recent applications in clinical analysis

“…A glucose quantification in artificial urine using a paper-based microfluidic devices with electrochemical detection (μPED) and glucose oxidase was reported in 2010 by Whiteside's group [26]. As highlighted by the authors, the developed μPED confines fluids in the paper channel and inhibits the convective movement of fluids, facilitating the chronoamperometric measurements (Fig.…”

Thread as a Matrix for Biomedical Assays

“…We and others have used hydrophilic paper as the basis for diagnostic assays (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). One strategy for using paper for diagnostic devices is to pattern channels into the paper using lines of hydrophobic polymer; the hydrophilic channels thus define the microfluidic paper analytical devices (µ-PADs) (3).…”