Electrochemical sensing based on DNA nanotechnology

Kogikoski, Sergio; Paschoalino, Waldemir J.; Cantelli, Lory; Silva, W. L. A. P.; Kubota, Lauro T.

doi:10.1016/j.trac.2019.06.021

Cited by 41 publications

(22 citation statements)

References 87 publications

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“…Proof: For any initial value (A(0), E (0), F (0)) ∈ R 3 + , there is a unique global positive solution for system (5), so R 3 + is regarded as the whole space. It is easy to verify that the coefficient of the system (5) satisfies the condition (9). According to Lemma 1, in order to prove Theorem 1, it successfully found a C 2 function V (t, A, F, E ) and a closed set U ∈ R 3 + which makes condition (12) hold.…”

Section: The Existence Of Nontrivial Positive Periodic Solutionsmentioning

confidence: 95%

Analysis of Periodic Solution of DNA Catalytic Reaction Model With Random Disturbance

Zhang

2021

IEEE Open J. Nanotechnol.

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The realization of molecular logic circuit is inseparable from the design and analysis of catalytic reaction chain, and the DNA catalytic gate plays an important role in it. Discuss the nature of the solution to DNA catalytic reaction system, using Khasminskii's periodicity and Lyapunov analysis methods to obtain the existence of non-trivial positive periodic solutions of the system, and the solution is globally attractive. The existence of the solution indicates that according to the mathematical model established by the DNA catalytic reaction system, the system may reach the expected concentration value of an ideal state and obtain better reaction data, which provides a theoretical basis for the realization of the DNA catalytic gate function. Numerical simulation results show that under the influence of random disturbance and periodic parameters, the solution to the random DNA catalytic reaction system exists and is globally attractive, which also reflects that the DNA catalytic reaction system can reach an ideal reaction state. The solution to the DNA catalytic system with random disturbance will converge on a certain value and oscillate periodically between the solution to the deterministic system.

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Section: The Existence Of Nontrivial Positive Periodic Solutionsmentioning

confidence: 95%

Analysis of Periodic Solution of DNA Catalytic Reaction Model With Random Disturbance

Zhang

2021

IEEE Open J. Nanotechnol.

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“…Using DNA as a platform for NP assembly is a powerful strategy to create an organized structure that is able to perform different functions, such as enhancing sensing signals [114,115] or creating plasmonic effects [116,117] . DNA architecture provides the desired controllability and programmability as a building block [118] . Its surface is fully addressable and can be easily modified to incorporate different chemical species/structures such as nanoparticles, with high positional precision [119] …”

Section: Bio‐templates For the Synthesis Of Mnmsmentioning

confidence: 99%

Recent Advances in Bio‐Templated Metallic Nanomaterial Synthesis and Electrocatalytic Applications

et al. 2020

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Developing metallic nanocatalysts with high reaction activity, selectivity and practical durability is a promising and active subfield in electrocatalysis. In the classical “bottom‐up” approach to synthesize stable nanomaterials by chemical reduction, stabilizing additives such as polymers or organic surfactants must be present to cap the nanoparticle to prevent material bulk aggregation. In recent years, biological systems have emerged as green alternatives to support the uncoated inorganic components. One key advantage of biological templates is their inherent ability to produce nanostructures with controllable composition, facet, size and morphology under ecologically friendly synthetic conditions, which are difficult to achieve with traditional inorganic synthesis. In addition, through genetic engineering or bioconjugation, bio‐templates can provide numerous possibilities for surface functionalization to incorporate specific binding sites for the target metals. Therefore, in bio‐templated systems, the electrocatalytic performance of the formed nanocatalyst can be tuned by precisely controlling the material surface chemistry. With controlled improvements in size, morphology, facet exposure, surface area and electron conductivity, bio‐inspired nanomaterials often exhibit enhanced catalytic activity towards electrode reactions. In this Review, recent research developments are presented in bio‐approaches for metallic nanomaterial synthesis and their applications in electrocatalysis for sustainable energy storage and conversion systems.

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“…For DLG biosensors, logic calculations are generally obtained by a three‐step procedure (Scheme 1), as follows: (a) targets are recognized as inputs by the biosensor, 19 (b) strand displacement reactions or conformational change occur, 20 and (c) outputs are generated with a recognizable readout 21 . To recognize output signals, multi‐step procedures such as fluorescent labeling, amplification, sequencing, or imaging are commonly required.…”

Section: Introductionmentioning

confidence: 99%

“…To recognize output signals, multi‐step procedures such as fluorescent labeling, amplification, sequencing, or imaging are commonly required. Up to date, various basic logic gates have been realized with output signals detected by different instrumentation techniques, including fluorescence, 22 luminescence, 23 electrochemistry, 19 and colorimetry 24 . Here, we sort these highly diverse DLG biosensors into three groups briefly according to their operational environment, e.g., solution, interfaces, and cellular environment.…”

Section: Introductionmentioning

confidence: 99%

Biosensors based on DNA logic gates

Yin

Wang

Chen

et al. 2020

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Biosensor is a device that responds to a particular target in a selective way by incorporation of biological recognition as sensing unit. For practical biomedical applications, a digital output (a qualitative YES/NO answer) is highly demanded for certain end‐user or point‐of‐care applications. Boolean logic, which can be applied to any type of information expressed as 0 (NO) and 1 (YES), is widely employed to achieve such qualitative analysis. Over the past decade, owing to DNA's advantages of stability, accessibility, and manipulability, significant research efforts have been focused on the design and application of DNA logic gates (DLG)‐based biosensors capable of implementing logic‐gated biomedical functions. This review summarizes the existed representative examples and the advanced developments of DLG biosensors, and discusses the limitations and the future directions on the development of novel nanosensors based on DNA logic operations for realizing highly efficient diagnosis.

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Electrochemical sensing based on DNA nanotechnology

Cited by 41 publications

References 87 publications

Analysis of Periodic Solution of DNA Catalytic Reaction Model With Random Disturbance

Analysis of Periodic Solution of DNA Catalytic Reaction Model With Random Disturbance

Recent Advances in Bio‐Templated Metallic Nanomaterial Synthesis and Electrocatalytic Applications

Biosensors based on DNA logic gates

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