Electrochemical red-ox therapy of prostate cancer in nude mice

Direct electric current modifies important cellular aspects and ultrastructure features of Candida albicans yeasts: Influence of doses and polarities

“…Previous studies developed with direct electric current indicated the importance of pH variation in tumoral [Veiga et al, ; Cury et al, ; Holandino et al, ] and non‐tumoral damage [Gomes et al, , ]. For that reason, pH variation was registered with the same values of electric charge previously evaluated in cell viability experiments.…”

“…DC cytotoxic effects are dependent on polarity, intensity, and exposure time to this physical agent [Gault and Gatens, 1976;Nordenstr€ om, 1994;Brighton et al, 1995;Veiga et al, 2000;Holandino et al, 2001;Vijh, 2004;Von Euler et al, 2004;Cury et al, 2015;Holandino et al, 2016]. Despite the efficacy of DC treatment, the mechanisms of action, as well as the absence of clinical standard protocol, are important reasons to motivate further direct electric current studies.…”

“…When it comes to fungus, previous papers showed DC susceptibility of C. albicans , especially when treated with silver electrodes [Berger et al, ; Aydin et al, ; Devrim Seçinti et al, ]. DC effects are also related to polarity and intensity in different cellular models, including tumoral cells, protozoa, and bacteria [Veiga et al, ; Gomes et al, ; Ciria et al, ; Cury et al, ; Holandino et al, ].…”

Mutagenic and genotoxic potential of direct electric current in Escherichia coli and Salmonella thyphimurium strains

“…Another important biological DC property is its anticancer potential, commonly known as electrochemical treatment (EChT) [Nordenström, , ; Liu et al, ; Nilsson et al, ; Ciria et al, , ]. Advantages of EChT include its local action (i.e., damage can be focused on the tumor), with minor effects to surrounding tissues, slight and self‐limited adverse effects, as well as low cost [Ciria et al, ; Cury et al, ]. Besides, EChT uses inert electrodes, which can be distributed in different positions and distances, as well as linked to specific polarities [Miklavčič et al, , ; Li et al, ; Jiménez et al, ].…”

“…Besides, EChT uses inert electrodes, which can be distributed in different positions and distances, as well as linked to specific polarities [Miklavčič et al, , ; Li et al, ; Jiménez et al, ]. Most DC effects on EChT have been attributed to electrolytic products resulting from anodic or cathodic reactions [Veiga et al, ; Cury et al, ]. Anodic reactions, generated by anodic flow induced dryness and local acidity.…”