Electrochemical K-562 cells sensor based on origami paper device for point-of-care testing

Ge, Shenguang; Zhang, Lina; Zhang, Yan; Liu, Haiyun; Huang, Jiadong; Yan, Mei; Yu, Jinghua

doi:10.1016/j.talanta.2015.05.008

Cited by 53 publications

(25 citation statements)

References 40 publications

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“…53 Moreover, AuNPs can be used in combination with materials such as graphene, which has been exploited for the detection of K-562 cells, one of the most aggressive human chronic myelogenous leukemia cell lines. 54 In another report that aimed to detect multiple cancer cells, AuNPs were conjugated to palladium and concanavalin-A bioconjugates in order to improve detection. 55 In order to detect acetaminophen in the presence of ascorbic acid, conjugation of AuNPs to polyglutamic acid and single wall carbon nanotubes was implemented by Lee and colleagues.…”

Section: ·4 Electrodes Characterization: Fabrication and Surface Modmentioning

confidence: 99%

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Trends in Paper-based Electrochemical Biosensors: From Design to Application

et al. 2018

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Electrochemical bio-sensing using paper-based detection systems is the main focus of this review. The different existing designs of 2-dimensional and 3-dimensional sensors, and fabrication techniques are discussed. This review highlights the effect of adopting different sensor designs, distinct fabrication techniques, as well as different modification methods, in order to produce reliable and reproducible reading. The use of various nanomaterials have been demonstrated in order to modify the surface of electrodes during fabrication to further enhance the signal for subsequent analysis. The reviewed sensors were classified into categories based on their applications, such as diagnostics, environmental and food testing. One of the major advantages of using paper-based electrochemical sensors is the potential for miniaturization, which only requires relatively small amount of samples, and the low cost for the purpose of mass production. Additionally, most of the devices reviewed were made to be portable, making them well-suited for on-site detection. Finally, paper-based detection is an ideal platform to fabricate cost-effective, user-friendly and sensitive electrochemical biosensors, with large capacity for customization depending on functional needs.

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Section: ·4 Electrodes Characterization: Fabrication and Surface Modmentioning

confidence: 99%

“…54 In this biosensor, 3D Au nanoparticles/graphene composite was added onto the working electrode, which resulted in a higher specific surface area that allowed for more concanavalin A (Con A) attachment as well as enhancement in electronic transmission.…”

Section: ·1 Clinical Diagnosticsmentioning

confidence: 99%

Trends in Paper-based Electrochemical Biosensors: From Design to Application

et al. 2018

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“…An interesting portable graphene-based sensor in conjugation with 3D-AuNPs was fabricated on origami-paper for the detection of H 2 O 2 release from K-562 cells via the simulation of phorbol 12-myristase-13-acetate. 134 Tehrani et al have fabricated a highly sensitive, inexpensive, and disposable graphene-copper based glucose biosensor chip for selective non-enzymatic glucose detection. The electrochemical properties of the modified graphene electrodes were inspected by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and amperometry with a LOD of 0.025-0.9 mM.…”

Section: Electrochemical Based Biosensing Systemmentioning

confidence: 99%

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

2017

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Graphene has emerged as a champion material for a variety of applications cutting across multiple disciplines in science and engineering. Graphene and its derivatives have displayed huge potential as a biosensing material due to their unique physicochemical properties, good electrical conductivity, optical properties, biocompatibility, ease of functionalization, and flexibility. Their widespread use in making biosensors has opened up new possibilities for early diagnosis of life-threatening diseases and real-time health monitoring. Following an introduction and discussion on the significance of fabrication protocols and assembly, this review is intended to assess why graphene is suitable to build better biosensors, the working of existing biosensing schemes and their current status toward commercialization for wearable diagnostic and prognostic devices. We believe this review will provide a critical insight for harnessing graphene as a suitable biosensor for the clinical diagnostics, its future prospects and challenges ahead.

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“…Nevertheless, the direct measurement of an electroactive product of the reaction (e.g., H 2 O 2 ) in first generation biosensor configurations [35], or direct electron transfer based enzyme biosensors (third generation) were reported [32,43]. Several screen-printed paper-based affinity biosensors have also been proposed (e.g., immunosensors) [34,38]; although the biorecognition event is based on a non-catalytic process (e.g., antigen–antibody interaction) these are frequently coupled with signal amplification systems composed of redox enzymes or enzyme-like electrocatalysts.…”

Section: Paper-based Electrochemical Biosensorsmentioning

confidence: 99%

“…A similar approach was proposed by Ge and co-workers for the construction of a paper-based biosensor for detecting K-562 cancer cells [38]. For this purpose, concanavalin A (Con A) was immobilized in a highly conductive and biocompatible electrode surface prepared with composites of 3D-AuNPs/graphene oxide (GN) and ionic liquid (IL) films (1-ethyl-3-methyl imidazolium tetra-fluoroborate ([BMIM]BF4)).…”

Section: Paper-based Electrochemical Biosensorsmentioning

confidence: 99%

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

2016

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From the bench-mark work on microfluidics from the Whitesides’s group in 2007, paper technology has experienced significant growth, particularly regarding applications in biomedical research and clinical diagnostics. Besides the structural properties supporting microfluidics, other advantageous features of paper materials, including their versatility, disposability and low cost, show off the great potential for the development of advanced and eco-friendly analytical tools. Consequently, paper was quickly employed in the field of electrochemical sensors, being an ideal material for producing custom, tailored and miniaturized devices. Stencil-, inkjet-, or screen-printing are the preferential techniques for electrode manufacturing. Not surprisingly, we witnessed a rapid increase in the number of publications on paper based screen-printed sensors at the turn of the past decade. Among the sensing strategies, various biosensors, coupling electrochemical detectors with biomolecules, have been proposed. This work provides a critical review and a discussion on the future progress of paper technology in the context of miniaturized printed electrochemical biosensors.

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Electrochemical K-562 cells sensor based on origami paper device for point-of-care testing

Cited by 53 publications

References 40 publications

Trends in Paper-based Electrochemical Biosensors: From Design to Application

Trends in Paper-based Electrochemical Biosensors: From Design to Application

Graphene based biosensors—Accelerating medical diagnostics to new-dimensions

Biosensing with Paper-Based Miniaturized Printed Electrodes–A Modern Trend

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