Electrochemical Impedance Spectroscopy: Evaluation of Drug Delivery System of Alpha-Tricalcium Phosphate Cement

Abstract

Tricalcium phosphate cement (α-TCP) can be used in various fields of health, including as drug delivery systems. The application of a biomaterial based on α-TCP could enable both the constant drug delivery as support and shape damaged muscleskeletics tissues until which can be regenerated by the organism itself, replacing the biomaterial, while maintaining stable levels of the drug in the organism. The aim of this study was to evaluate the release of gentamicin sulfate using the technique of electrochemical impedance spectroscopy in drug delivery systems of α-TCP. The results obtained in vitro study validated the proposed methodology for assessment of controlled drug delivery systems on the basis of α-TCP.

In situ drug release measuring in α-TCP cement by electrochemical impedance spectroscopy

“…Electrochemical impedance spectroscopy (EIS) is a widely used technique in the characterization of electrical materials that require specific electrical properties, for example, photovoltaic cells, materials submitted to corrosive environments, and fuel cells, amongst others [ 29 – 31 ]. It is a promising technique to determine the amount of drug transported to the body during the release processes, promoting a non-destructive and high sensitivity analysis of the characterized material [ 32 , 33 ].…”