Electrochemical biosensors: recommended definitions and classification1International Union of Pure and Applied Chemistry: Physical Chemistry Division, Commission I.7 (Biophysical Chemistry); Analytical Chemistry Division, Commission V.5 (Electroanalytical Chemistry).1

Thévenot, Daniel; Tóth, Klára; Durst, Richard A.; Wilson, George S.

doi:10.1016/s0956-5663(01)00115-4

Cited by 1,194 publications

(216 citation statements)

References 22 publications

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“…The first one is a biomolecule responsible for recognition of the target substance through specific intermolecular binding or by means of catalytic reactions (D’Orazio, 2003). The second is the transducer that converts the biochemical response into a measurable electric signal, which is mainly proportional to analyte concentration (Higgins and Lowe, 1987; Hulanicki et al, 1991; Thévenot et al, 2001). In addition, diverse transducers can be used for conversion of the biochemical response into a quantifiable analytical signal, being classified according to their physical principles as electrochemical, electrical, optical, piezoelectric, calorimetric, acoustic, and magnetic (Hulanicki et al, 1991; Sethi, 1994; Marco and Barcelo, 1996; Thévenot et al, 2001).…”

Section: Strategies For the Development Of Amp-based Biosensorsmentioning

confidence: 99%

Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis

Silva¹,

Avelino²,

Ribeiro³

et al. 2014

Front. Microbiol.

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Antimicrobial peptides (AMPs) are natural compounds isolated from a wide variety of organisms that include microorganisms, insects, amphibians, plants, and humans. These biomolecules are considered as part of the innate immune system and are known as natural antibiotics, presenting a broad spectrum of activities against bacteria, fungi, and/or viruses. Technological innovations have enabled AMPs to be utilized for the development of novel biodetection devices. Advances in nanotechnology, such as the synthesis of nanocomposites, nanoparticles, and nanotubes have permitted the development of nanostructured platforms with biocompatibility and greater surface areas for the immobilization of biocomponents, arising as additional tools for obtaining more efficient biosensors. Diverse AMPs have been used as biological recognition elements for obtaining biosensors with more specificity and lower detection limits, whose analytical response can be evaluated through electrochemical impedance and fluorescence spectroscopies. AMP-based biosensors have shown potential for applications such as supplementary tools for conventional diagnosis methods of microorganisms. In this review, conventional methods for microorganism diagnosis as well new strategies using AMPs for the development of impedimetric and fluorescent biosensors are highlighted. AMP-based biosensors show promise as methods for diagnosing infections and bacterial contaminations as well as applications in quality control for clinical analyses and microbiological laboratories.

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Section: Strategies For the Development Of Amp-based Biosensorsmentioning

confidence: 99%

Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis

Silva¹,

Avelino²,

Ribeiro³

et al. 2014

Front. Microbiol.

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“…They made up of a biological factor responsible for sampling, as well as a physical element (often called transducer) transmitting sampling outcome for moreover processing [5][6][7][8]. The biological element of a biosensor contains a biosensitive layer, which can either contain bioreceptors or be made of bioreceptors covalently attached to the transducer.Concerning the biological specificity conferring mechanism used one can distinguish 5 major categories of biosensors 1) Antibody/antigen based, 2) Enzymes based (mono-or multi enzyme systems) [9], 3) Nucleic acids based (DNA, cDNA, RNA) [10] 4) Based on cellular interactions (cellular structures/cells),utilisating the whole cells (microorganisms, such asbacteria, fungi, eukaryotic cells or yeast) or cell organellesor particles (mitochondria, cell walls, tissue slices) [11][12][13][14][15][16] 5) Employing biomimetic materials (e.g., synthetic bioreceptors).…”

Section: Biosensorsmentioning

confidence: 99%

The Application of Nanotechnology in Medical Sciences: New Horizon of Treatment

Moshed¹,

Sarkar²,

Khaleque³

2017

Am. J. Biomed. Sci.

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Nanotechnology has become enormously promising technology during last few decades and now it is estimated to have a significant effect on medical equipment. The possible effects of novel nanomedical applications on sickness identification, treatment, as well as anticipation are expected to improve healthiness care greatly. In addition, therapeutic selection may gradually be adapted to all patients' profile. Applications of nanomaterials are reported in operation, cancer diagnosis as well as therapy, biodetection of sickness markers, molecular imaging, implant technology, tissue engineering, as well as devices for drug, protein, and gene and radionuclide release. Various medical nanotechnology applications are at a standstill in their immaturity. A larger amount of nanodevices are presently under medical examination as well as several devices are commercially available. In this review work some applications of nanodevices in medical technology are also summarized.

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“…recognizes the analyte and catalyzes a reaction leading to consumption of the analyte, while in the bioaffinity system, the bioreceptor (e.g. antibody or aptamer) specifically binds to the analyte and an equilibrium is usually reached [21]. In Table 1, common types of biosensors according to different transduction pathways are listed and the related typical biological recognizing elements which are used for each type is defined.…”

Section: Introductionmentioning

confidence: 99%

Noble metal nanoparticles in biosensors: recent studies and applications

Malekzad

Zangabad

Mirshekari

et al. 2017

Nanotechnology Reviews

292

119

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The aim of this review is to cover advances in noble metal nanoparticle (MNP)-based biosensors and to outline the principles and main functions of MNPs in different classes of biosensors according to the transduction methods employed. The important biorecognition elements are enzymes, antibodies, aptamers, DNA sequences, and whole cells. The main readouts are electrochemical (amperometric and voltametric), optical (surface plasmon resonance, colorimetric, chemiluminescence, photoelectrochemical, etc.) and piezoelectric. MNPs have received attention for applications in biosensing due to their fascinating properties. These properties include a large surface area that enhances biorecognizers and receptor immobilization, good ability for reaction catalysis and electron transfer, and good biocompatibility. MNPs can be used alone and in combination with other classes of nanostructures. MNP-based sensors can lead to significant signal amplification, higher sensitivity, and great improvements in the detection and quantification of biomolecules and different ions. Some recent examples of biomolecular sensors using MNPs are given, and the effects of structure, shape, and other physical properties of noble MNPs and nanohybrids in biosensor performance are discussed.

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Electrochemical biosensors: recommended definitions and classification1International Union of Pure and Applied Chemistry: Physical Chemistry Division, Commission I.7 (Biophysical Chemistry); Analytical Chemistry Division, Commission V.5 (Electroanalytical Chemistry).1

Cited by 1,194 publications

References 22 publications

Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis

Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis

The Application of Nanotechnology in Medical Sciences: New Horizon of Treatment

Noble metal nanoparticles in biosensors: recent studies and applications

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