Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H2O2 released from H9C2 cardiac cells

Lu, Jing; Hu, Yuehuai; Wang, Panxia; Chen, Zuanguang; Sun, Duanping

doi:10.1016/j.snb.2020.127909

Cited by 72 publications

(35 citation statements)

References 51 publications

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“…However, the practical applications of ECBs for a wide variety of bioanalytes have not been completely realized. Besides the cost of the electrodes, the key technical factors that determine the applicability of ECBs in clinical purposes are: ease of preparation, sensitivity, accuracy, ECBs can be manufactured in miniaturized size that can be used as POCT devices for clinical purposes [45,46]. These POCT devices are often fabricated on paper strips or carbon paste electrodes based on lab-on-chip principles and can be used with a portable electroanalytical device [46,47].…”

Section: Introductionmentioning

confidence: 99%

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Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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With the rise in public health awareness, research on point-of-care testing (POCT) has significantly advanced. Electrochemical biosensors (ECBs) are one of the most promising candidates for the future of POCT due to their quick and accurate response, ease of operation, and cost effectiveness. This review focuses on the use of metal nanoparticles (MNPs) for fabricating ECBs that has a potential to be used for POCT. The field has expanded remarkably from its initial enzymatic and immunosensor-based setups. This review provides a concise categorization of the ECBs to allow for a better understanding of the development process. The influence of structural aspects of MNPs in biocompatibility and effective sensor design has been explored. The advances in MNP-based ECBs for the detection of some of the most prominent cancer biomarkers (carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), Herceptin-2 (HER2), etc.) and small biomolecules (glucose, dopamine, hydrogen peroxide, etc.) have been discussed in detail. Additionally, the novel coronavirus (2019-nCoV) ECBs have been briefly discussed. Beyond that, the limitations and challenges that ECBs face in clinical applications are examined and possible pathways for overcoming these limitations are discussed.

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Section: Introductionmentioning

confidence: 99%

“…ECBs can be manufactured in miniaturized size that can be used as POCT devices for clinical purposes [ 45 , 46 ]. These POCT devices are often fabricated on paper strips or carbon paste electrodes based on lab-on-chip principles and can be used with a portable electroanalytical device [ 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

et al. 2020

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“…This reproducibility is quite similar to that of the sensors made with GBMs (see Section 2). Most of the sensors made with non-graphene 2D materials retained at least 90% of their initial analytical signal after being stored (in different conditions) for time periods ranging from 7 days [82] to couple of weeks [74,75,78]. Only one sensor [76] was reported to retain less than 90% (85%) of its initial analytical signal after being stored for a time period of 30 days.…”

Section: Electrochemical Sensors Built With Non-graphene 2d Materialsmentioning

confidence: 99%

“…Figure 4 shows typical results obtained at cellular level with an electrochemical H 2 O 2 sensor built using MoS 2 . A glassy carbon electrode was modified first with a mixture of MoS 2 nanosheets and Fe 3 O 4 nanoparticles coated with ZIF-8 metal organic framework nanoparticles and then with Au nanoflowers in order to obtain the H 2 O 2 sensor [82]. Before using this H 2 O 2 sensor at cellular level, fluorescence microscopy and dihydroethidium (a probe sensitive to reactive oxygen species) were used to demonstrate that the selected cells (H9C2 rat cardiomyocytes) produce H 2 O 2 following stimulation with ascorbic acid (see Fig.…”

Section: Electrochemical Sensors Built With Non-graphene 2d Materialsmentioning

confidence: 99%

2D materials in electrochemical sensors for in vitro or in vivo use

et al. 2020

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Individual cells and cell populations are at the present time investigated with a myriad of analytical tools. While most of them are commercially available, some of these analytical tools are just emerging from research laboratories and are in the developmental phase. Electrochemical sensors which allow the monitoring of low molecular weight compounds released (and / or uptaken) by cells are among these emerging tools. Such sensors are increasingly built using 2D materials (e.g. graphene-based materials, transition metal dichalcogenides, etc.) with the aim of conferring better analytical performances to these devices. The present work critically reviews studies published during the last 10 years describing electrochemical sensors made with 2D materials and exploited to monitor small compounds (e.g. H 2 O 2 , •NO, glucose, etc.) in living biological systems. It also discusses the very few 2D material-based electrochemical sensors which are wearable or usable in vivo. Finally, the present work includes a specific section about 2D material biocompatibility, a fundamental requirement for 2D material-based sensor applications in vitro and in vivo. As such, the review provides a critical view on the state of the art of electrochemical sensors made with 2D materials and used at cellular level and it evaluates the possibility that such sensors will be used on / in the human body on a wider scale.

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“…They possess many promising features like tunable structures, active sites, rapid electron transmission, and high surface area (Lee et al, 2009;Gu et al, 2014). MOFs have been extensively used in electrochemical applications (Chen et al, 2020;Lu et al, 2020;Wei et al, 2020), gas storages (Hinks et al, 2010;Zhang et al, 2020), and biomedical fields like wound healing (Fu et al, 2020;Chen et al, 2021), enhanced cancer therapy (Luo et al, 2019), imaging (Lu et al, 2018), antibacterial agents (Qi et al, 2020), cell detection (Shi et al, 2021), and drug delivery (Simon-Yarza et al, 2018) because of excellent physical and chemical properties. In addition, MOFs with catalytic activity have become an ideal modified material of electrochemical sensors for detection in real samples (Guo et al, 2020;He et al, 2020;Liu et al, 2020;Zhang et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

2D/3D Copper-Based Metal-Organic Frameworks for Electrochemical Detection of Hydrogen Peroxide

et al. 2021

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Metal-organic frameworks (MOFs) have been extensively used as modified materials of electrochemical sensors in the food industry and agricultural system. In this work, two kinds of copper-based MOFs (Cu-MOFs) with a two dimensional (2D) sheet-like structure and three dimensional (3D) octahedral structure for H2O2 detection were synthesized and compared. The synthesized 2D and 3D Cu-MOFs were modified on the glassy carbon electrode to fabricate electrochemical sensors, respectively. The sensor with 3D Cu-MOF modification (HKUST-1/GCE) presented better electrocatalytic performance than the 2D Cu-MOF modified sensor in H2O2 reduction. Under optimal conditions, the prepared sensor displayed two wide linear ranges of 2 μM–3 mM and 3–25 mM and a low detection limit of 0.68 μM. In addition, the 3D Cu-MOF sensor exhibited good selectivity and stability. Furthermore, the prepared HKUST-1/GCE was used for the detection of H2O2 in milk samples with a high recovery rate, indicating great potential and applicability for the detection of substances in food samples. This work provides a convenient, practical, and low-cost route for analysis and extends the application range of MOFs in the food industry, agricultural and environmental systems, and even in the medical field.

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Electrochemical biosensor based on gold nanoflowers-encapsulated magnetic metal-organic framework nanozymes for drug evaluation with in-situ monitoring of H2O2 released from H9C2 cardiac cells

Cited by 72 publications

References 51 publications

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

Metal Nanoparticles for Electrochemical Sensing: Progress and Challenges in the Clinical Transition of Point-of-Care Testing

2D materials in electrochemical sensors for in vitro or in vivo use

2D/3D Copper-Based Metal-Organic Frameworks for Electrochemical Detection of Hydrogen Peroxide

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