Electrochemical biosensing based on polypyrrole/titania nanotube hybrid

Xie, Yibing; Zhao, Ye

doi:10.1016/j.msec.2013.08.036

Cited by 31 publications

(21 citation statements)

References 23 publications

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“…The surface affinity of electrode substrate materials is critical for GOx immobilization. The hydrophilicity of electrode substrate materials is strongly related to enzymic bioelectrocatalytic activity . Water contact angle measurement was carried out to assess the hydrophilic properties of electrode materials.…”

Section: Resultsmentioning

confidence: 99%

“…The hydrophilicity of electrode substrate materials is strongly related to enzymic bioelectrocatalytic activity. 34 Water contact angle measurement was carried out to assess the hydrophilic properties of electrode materials. Usually, the water contact angle directly reflects the wettability of materials, which is related to the hydrophilicity and surface roughness.…”

Section: Electrochemical Performance Of Different Electrodesmentioning

confidence: 99%

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Bioelectrocatalytic performance of glucose oxidase/nitrogen-doped titania nanotube array enzyme electrode

Xie

Wang

2015

J. Chem. Technol. Biotechnol.

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BACKGROUND The substrate materials of enzyme electrodes strongly affect bioelectrocatalytic activity. TiO2 nanotube arrays (NTAs) show good affinity to glucose oxidase (GOx) but low conductivity. TiN NTAs show good conductivity but low affinity to GOx. Nitrogen‐doped TiO2 (N‐TiO2) NTA with good hydrophilicity and conductivity was designed to prepare a GOx/N‐TiO2 NTA enzyme electrode to promote bioelectrocatalytic performance. RESULTS N‐TiO2 NTA had a well‐ordered nanoarray structure with slightly distorted pore mouth and wrinkled nanotube wall. N‐TiO2 NTA exhibited decreased charge transfer resistance and similar contact angle to TiO2 NTA, presenting high electrical conductivity and good hydrophilicity. GOx/N‐TiO2 NTA exhibited highly increased current response at a potential of −0.45 V, presenting good bioelectrocatalysis towards glucose. A GOx/N‐TiO2 NTA enzyme electrode was used to fabricate a glucose biosensor, showing a high sensitivity of 733.17 µA mM−1 cm−2 and a linear range of 0.05–0.85 mmol L−1 and low detection limit of 2.9 µmol L−1 for glucose determination. It exhibited high selectivity in the presence of common interfering substances and was used to determine glucose in serum. It also had good reproducibility and long‐time storage stability. In addition, the GOx/N‐TiO2 NTA enzyme electrode was used to fabricate a glucose fuel cell, showing maximum power density of 23.92 µW cm−2 as well as good bioelectrocatalytic stability. CONCLUSION High bioelectrocatalytic activity and stability of GOx/N‐TiO2 NTA proved that N‐TiO2 NTA could act as a reasonable supporting substrate material for enzyme electrodes for various bioelectrocatalytic applications. © 2015 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Section: Electrochemical Performance Of Different Electrodesmentioning

confidence: 99%

Bioelectrocatalytic performance of glucose oxidase/nitrogen-doped titania nanotube array enzyme electrode

Xie

Wang

2015

J. Chem. Technol. Biotechnol.

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“…The conductive composite was formed using electropolymerization of Py on a G surface, followed by acid treatment. Inorganic nanoparticles incorporated into CP layers also improve the analytical parameters of biosensors [220], [221], [222]. A sensitive electrochemical biosensor for the detection of L-glutamate, based on immobilization of glutamate oxidase (GluOx) onto a PPy/zinc oxide nanorod (ZnONR)…”

Section: Undoped Icps and Cross-linked Icpsmentioning

confidence: 99%

“…The biosensor showed an optimum response at pH 8. Zhao [221]. GOD was immobilized onto PPy/TiO2 nanotubes (TiO2NT) via a glutaraldehyde cross-linker ( Fig.…”

Section: Undoped Icps and Cross-linked Icpsmentioning

confidence: 99%

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Tomczykowa

Płońska‐Brzezińska

2019

Preprint

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This review is focused on current state-of-the-art research on electroactive-based materials and their synthesis, as well as their physicochemical and biological properties. Special attention is paid to pristine intrinsically conducting polymers (ICPs) and their composites with other organic and inorganic components, well-defined micro- and nanostructures, and enhanced surface areas compared with those of conventionally prepared ICPs. Hydrogels, due to their defined porous structures and being filled with aqueous solution, offer the ability to increase the amount of immobilized chemical, biological or biochemical molecules. When other components are incorporated into ICPs, the materials form composites; in this particular case, they form conductive composites. The design and synthesis of conductive composites result in the inheritance of the advantages of each component and offer new features because of the synergistic effects between the components. The resulting structures of ICPs, conducting polymer hydrogels and their composites, as well as the unusual physicochemical properties, biocompatibility and multi-functionality of these materials, facilitate their bioapplications. The synergistic effects between constituents have made these materials particularly attractive as sensing elements for biological agents, and they also enable the immobilization of bioreceptors such as enzymes, antigen–antibodies, and nucleic acids onto their surfaces for the detection of an array of biological agents. Currently, these materials have unlimited applicability in biomedicine. In this review, we have limited discussion to three areas in which it seems that the use of ICPs and materials, including their different forms, are particularly interesting, namely, biosensors, delivery of drugs and tissue engineering.

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“…To improve its property, for example, Xie and Zhao used a conducting polymer (polypyrrole) to coat the TiNT array surface for developing a glucose biosensor. 11 Alternatively, one effective method is to load a noble metal, especially gold nanoparticles, onto the TiNT array surface. This is because Au nanoparticles have a good catalytic activity on the supporting material, depending on the particle size, dispersion, and composition.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Highly Uniform Gold Nanoparticles-Titanium Dioxide Nanotube Arrays for H2O2 Sensing

Puttharugsa

Aeimbhu

2018

ANAL. SCI.

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This research was to prepare the titanium dioxide nanotube arrays (TiNT arrays) and deposit the Au nanoparticles on its surface using the pulse electrodeposition technique. The Au nanoparticles-TiNT arrays (AuNP-TiNT arrays) were characterized by field emission scanning electron microscopy (FESEM), X-ray diffraction, and cyclic voltammetry. The results showed that the Au nanoparticles were uniformly dispersed on the TiNT array surface. The size and loading of Au nanoparticles can be controlled by deposition time, deposition potential, and concentration of HAuCl. The AuNP-TiNT arrays were then used as a working electrode for hydrogen peroxide (HO) detection. Compared with the pure TiNT array electrode, the AuNP-TiNT array electrode had higher sensitivity for the detection of HO and thus provided a simple, promising, and cost-effective sensing platform for the development of enzyme-based biosensors.

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Electrochemical biosensing based on polypyrrole/titania nanotube hybrid

Cited by 31 publications

References 23 publications

Bioelectrocatalytic performance of glucose oxidase/nitrogen-doped titania nanotube array enzyme electrode

Bioelectrocatalytic performance of glucose oxidase/nitrogen-doped titania nanotube array enzyme electrode

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Fabrication of Highly Uniform Gold Nanoparticles-Titanium Dioxide Nanotube Arrays for H2O2 Sensing

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