Electrochemical behavior and voltammetric determination of norfloxacin at glassy carbon electrode modified with multi walled carbon nanotubes/Nafion

Huang, Ke‐Jing; Li, Xue; Xie, Wan-Zhen; Yuan, Hao

doi:10.1016/j.colsurfb.2008.02.003

Cited by 90 publications

(49 citation statements)

References 28 publications

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“…This finding was in agreement with those reported for the oxidation of fluoroquinolones, such as norfloxacin. 16 The effects of the scan rate on the peak currents and the peak potentials of ENRO and CIPRO at the modified GCE were investigated in a 0.1 mol L -1 PBS using LSV in the presence of 100.0 μmol L -1 ENRO and 100.0 μmol L -1 CIPRO. The results showed that the anodic peak currents of both compounds increased linearly with the square root of the scan rate, while the ENRO and CIPRO overlap also increased.…”

Section: Effect Of Variables On the Peak Potentials And Peak Currentsmentioning

confidence: 99%

Simultaneous Voltammetric Determination of Enrofloxacin and Ciprofloxacin in Urine and Plasma Using Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode by Least-Squares Support Vector Machines

et al. 2010

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803Fluoroquinolones are a class of synthetic antibacterial agents, which are known for their broad spectrum of antibacterial activity. These compounds are derived from nalidixic acid and naphthyridine derivatives, which have been introduced for clinical applications in the livestock and farming industries.1 In this work, two important fluoroquinolones, namely enrofloxacin (1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid) and ciprofloxacin (1-cyclopropyl-7-(1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid), were investigated and quantitatively analyzed by voltammetric methods. In several animal species, including pigs, enrofloxacin (ENRO) is de-ethylated to its primary metabolite, ciprofloxacin (CIPRO), 2 and both ENRO and CIPRO are found in the bile and urine of animals receiving ENRO. Electrochemical methods, such as polarography and voltammetry, have high sensitivity and are widely used in many areas of analytical chemistry.Recently, cathodic adsorptive stripping voltammetry on a static mercury drop electrode and principal-component regression have been applied for the determination of ENRO in the presence of CIPRO 10 at trace levels. However, the linear dynamic range of the method is too narrow, and the toxicity of mercury (as an electrode) has caused its application in routine laboratories to decline. At more negative potentials, many biological compounds are adsorbed on the surface of the Hg-electrode, diminishing the selectivity of the method. 10 On the other hand, simultaneous voltammetric determinations of ENRO and CIPRO have not been reported, since ENRO affects the oxidation potential of CIPRO and vice versa. Therefore, the direct determination of CIPRO in the presence of ENRO is not possible by univariate calibration methods.In this work, linear sweep voltammetry (LSV) used for the first time with a multiwall carbon nanotubes/glassy carbon electrode (MWCNT/GCE) provides a sensitive method for the determination of ENRO or CIPRO in the presence of the other without any pretreatment or separation. When MWCNT/GCE is used as a working electrode in the voltammetric method, ENRO affects the oxidation potential of CIPRO, whereas CIPRO does not affect that of ENRO. Because it was possible to measure ENRO without any interfering effect of CIPRO, a least-squares support vector machine (LS-SVM) model was constructed in this study to relate a CIPRO voltammogram to its concentration. The model predicts CIPRO concentration in both spiked human plasma and pharmaceutical samples. The proposed methodology is fast and simple, while it does not generate hazardous chemical wastes. Theory of Least Square Support Vector RegressionSupport vector machines (SVMs) based on statistical learning theory were introduced by Cortes and Vapnik.11 LS-SVMs are an alternate formulation of SVM described by Suykens et al. 12 Here, we only briefly describe the theory of LS-SVM. Linear least-squares models fit a linear relation between the spectrum xi and the reference va...

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Section: Effect Of Variables On the Peak Potentials And Peak Currentsmentioning

confidence: 99%

Simultaneous Voltammetric Determination of Enrofloxacin and Ciprofloxacin in Urine and Plasma Using Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode by Least-Squares Support Vector Machines

et al. 2010

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“…Adsorption has been proved to be an effective way to deal with such kind of contaminants in water. Various materials, such as carbon nanotubes [16], clay minerals, and activated carbon [15], have been used as adsorbents to remove NFX.…”

mentioning

confidence: 99%

Efficient adsorption of Norfloxacin by Fe-MCM-41 molecular sieves: Kinetic, isotherm and thermodynamic studies

Chen

Pan

et al. 2015

Chemical Engineering Journal

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“…A simple and rapid electrochemical method was developed for the determination of trace-level norfloxacin, based on the excellent properties of multi-walled carbon nanotubes (MWCNTs) [72]. The MWCNTs/Nafion film-coated glassy carbon electrode was constructed and the electrochemical behavior of norfloxacin at the electrode was investigated in detail.…”

Section: Electrochemistry Of Fluoroquino-lones At Modified Electrodesmentioning

confidence: 99%

Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions

Radi¹

2010

TOCBMJ

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This mini review describes the results regarding the voltammetric determination of micromolar, submicromolar and nanomolar concentrations of various fluoroquinolones antibacterial agents using both traditional hanging mercury drop electrode, carbon paste electrode, glassy carbon paste electrode and chemically modified electrodes. We concentrate on the interaction of quinolones with DNA in solution and at electrode surface in the context of the general development in the field.

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Electrochemical behavior and voltammetric determination of norfloxacin at glassy carbon electrode modified with multi walled carbon nanotubes/Nafion

Cited by 90 publications

References 28 publications

Simultaneous Voltammetric Determination of Enrofloxacin and Ciprofloxacin in Urine and Plasma Using Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode by Least-Squares Support Vector Machines

Simultaneous Voltammetric Determination of Enrofloxacin and Ciprofloxacin in Urine and Plasma Using Multiwall Carbon Nanotubes Modified Glassy Carbon Electrode by Least-Squares Support Vector Machines

Efficient adsorption of Norfloxacin by Fe-MCM-41 molecular sieves: Kinetic, isotherm and thermodynamic studies

Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions

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