2010
DOI: 10.1073/pnas.1011315107
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Electrochemical and homogeneous electron transfers to the Alzheimer amyloid-β copper complex follow a preorganization mechanism

Abstract: Deciphering the electron transfer reactivity characteristics of amyloid β-peptide copper complexes is an important task in connection with the role they are assumed to play in Alzheimer’s disease. A systematic analysis of this question with the example of the amyloid β-peptide copper complex by means of its electrochemical current–potential responses and of its homogenous reactions with electrogenerated fast electron exchanging osmium complexes revealed a quite peculiar mechanism: The reaction proceeds through… Show more

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Cited by 115 publications
(195 citation statements)
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“…Cu weakly bound to buffer is the most efficient species in consuming Asc and producing HO • . Cu(II) coordination to Aβ significantly slows down both processes, in line with a sluggish redox cycling of the Cu(Aβ) complex compared to "free" Cu [21]. Cu(II) coordination to H 2 L 2− lowers Asc consumption and HO • formation to the background level, in line with no cathodic process observed down to −0.6 V vs. NHE (normal hydrogen electrode) by voltammetry (Fig.…”
Section: Inhibition Of Cu(aβ) Ros Productionsupporting
confidence: 60%
“…Cu weakly bound to buffer is the most efficient species in consuming Asc and producing HO • . Cu(II) coordination to Aβ significantly slows down both processes, in line with a sluggish redox cycling of the Cu(Aβ) complex compared to "free" Cu [21]. Cu(II) coordination to H 2 L 2− lowers Asc consumption and HO • formation to the background level, in line with no cathodic process observed down to −0.6 V vs. NHE (normal hydrogen electrode) by voltammetry (Fig.…”
Section: Inhibition Of Cu(aβ) Ros Productionsupporting
confidence: 60%
“…37,40 These latter species are expected to be particularly stable when both, His13 and His14, coordinate to the metal through the δ nitrogen of imidazole. 65 Computed SRP value for Ia is in very good agreement with the most recent experimental values determined for Cu 2+ -Aβ (1−16) complex (between 0.28 and 0.34V), 45,66,67 in accordance with the fact that this is the dominant species at pH ∼7.…”
Section: Standard Reduction Potential Calculationssupporting
confidence: 75%
“…Furthermore, irreversible Cu(II)/Cu(I) redox processes were remarked for complexes of both Aβ peptides at potentials less positive than 0.5 V. Consistent with the previously proposed low affinity binding at His13 and His14, 14,31,32 two small anodic peaks at ca. 0.0 V and 0.4 V were observed for Aβ (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) and Aβ(1-16) mixed with 1.8 Cu(II) equiv (see Figs. 2A-2B), together with just one return cathodic peak, evidencing an irreversible Cu(II)/Cu(I) conversion.…”
Section: Methodsmentioning
confidence: 86%