Electrocatalytic Study of Paracetamol at a Single-Walled Carbon Nanotube/Nickel Nanocomposite Modified Glassy Carbon Electrode

Abstract

A rapid, simple, and sensitive method for the electrochemical determination of paracetamol was developed. A single-walled carbon nanotube/nickel (SWCNT/Ni) nanocomposite was prepared and immobilized on a glassy carbon electrode (GCE) surface via mechanical attachment. This paper reports the voltammetry study on the effect of paracetamol concentration, scan rate, pH, and temperature at a SWCNT/Ni-modified electrode in the determination of paracetamol. The characterization of the SWCNT/Ni/GCE was performed by cyclic voltammetry. Variable pressure scanning electron microscopy (VPSEM) and energy dispersive X-ray (EDX) spectrometer were used to examine the surface morphology and elemental profile of the modified electrode, respectively. Cyclic voltammetry showed significant enhancement in peak current for the determination of paracetamol at the SWCNT/Ni-modified electrode. A linear calibration curve was obtained for the paracetamol concentration between 0.05 and 0.50 mM. The SWCNT/Ni/GCE displayed a sensitivity of 64 mA M−1and a detection limit of 1.17 × 10−7 M in paracetamol detection. The proposed electrode can be applied for the determination of paracetamol in real pharmaceutical samples with satisfactory performance. Results indicate that electrodes modified with SWCNT and nickel nanoparticles exhibit better electrocatalytic activity towards paracetamol.

Multiwalled carbon nanotubes decorated with bismuth (III) oxide for electrochemical detection of an antipyretic and analgesic drug paracetamol in biological samples

“…The modification has also been applied in an attempt to reduce poor voltammetric responses caused by sluggish electrode kinetics and electrode fouling encountered at bare electrode which decrease sensitivity and reproducibility (Bouabi et al 2016). Modifiers such as multiwalled carbon nanotube-cetyltrimethyl ammonium (Gowda et al 2015), chitosan (Bouabi et al 2016), graphene (Kang et al 2010), carbon nano-tube composite film (Li et al 2006), magnesium diboride microparticles (Zidan et al 2011a(Zidan et al , 2011b, nafion/TiO 2 -graphene (Fan et al 2011), bismuth oxide nanoparticles (Zidan et al 2011a(Zidan et al , 2011b, nickel and nickel-copper alloy (Feizbakhsh et al 2012), graphene oxide (Zidan et al 2014), multiwalled carbon nanotubes and dopamine nanospheres functionalized with gold nanoparticles (Liu et al 2014), nickel oxide nanoparticles and carbon black (Deroco et al 2014), cuprous oxide nanoparticles-graphene (Yang et al 2015), graphene (Fernandez et al 2015), single-walled carbon nanotube/ nickel nanocomposite (Ngai et al 2015), cadmium selenide microspheres (Yin et al 2012), and poly(glycine) (Kuskur et al 2015) have offered great success for the decrease in overpotential and increase of sensitivity during oxidation of paracetamol. Even though the aforementioned modifiers have proved to be effective, a search for new combinations should still continue so that better sensitivity, selectivity, and good stability are achieved during electrochemical detection.…”

Cephradine-Capped Gold Nanoparticle Modified Glassy Carbon Electrode for Trace Level Sensing of Triphenyltin Hydroxide

“…Other reports regarding the sensitive detection of other analytes through CV have been presented elsewhere. [34][35][36] Effect of electrolyte.-Three electrolytes, acetate buffer, phosphate buffer and Britton Robinson buffer (BRB) were tested for selecting electrolyte with the best choice in order to get best shaped voltammogram with highest peak current for determination of TPTH. According to Fig.…”

Fabrication of Carbon@Co Nanocages/Nafion/Poly Tiopronin Composite Film and Its Application for Determination of Acetaminophen

“…16 In the last ten years, the use of modified electrodes for the quantification of acetaminophen has considerably increased. 17 A wide variety of materials such as graphene composites, 18,19 gold composites [20][21][22] and carbon nanotubes composites [23][24][25] were used for modifying electrode. However, to the best of our knowledge, electrochemical determination of acetaminophen using carbon@Co nanocages/ nafion/poly tiopronin composite modified electrode has not been reported.…”