Electrocardiographic Analysis of Heart Rate Variability in Aging Heart

Santillo, Elpidio; Migale, Monica; Fallavollita, Luca; Marini, Luciano; Balestrini, Fabrizio

doi:10.5772/22538

Cited by 6 publications

(4 citation statements)

References 95 publications

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“…Aging is linked to a decline in cardiovascular control (Colosimo et al., 1997) and substantial research shows that aging is associated with a decrease in HRV and sympathovagal imbalance (O’Brien et al., 1986; Russoniello, 2013; Santillo et al., 2012). The age‐related reduction in resting HRV has been observed in both cross‐sectional comparisons and in a longitudinal study (Sinnreich et al., 1998).…”

Section: Introductionmentioning

confidence: 99%

Age‐related losses in cardiac autonomic activity during a daytime nap

et al. 2020

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The autonomic nervous system (ANS) plays a major role in cardiovascular adaptations to environmental changes and is thus critical for global allostasis (McEwen, 2002), or the ability of organisms to maintain stability, adaptability, and health in response to actual or perceived environmental and psychological demands. The ANS is generally conceived to have two major branches-the sympathetic system, associated with energy mobilization, and the parasympathetic system, associated with vegetative and restorative functions. In healthy adults, the activity of these branches is in dynamic

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Section: Introductionmentioning

confidence: 99%

Age‐related losses in cardiac autonomic activity during a daytime nap

et al. 2020

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“…HRV is also linked to other aspects of health that are directly impacted by autonomic function such as self-regulatory capacity and psychological and physiological stress [5,9,10]. Most HRV metrics are shown to decline normally with age, primarily during younger decades, and some of these metrics increase again after the seventh decade [4,[11][12][13][14][15]. In studies of older adults, low HRV measured by electrocardiogram (ECG) recordings has shown preliminary relationships with physical frailty [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Associations Between Heart Rate Variability Measured With a Wrist-Worn Sensor and Older Adults’ Physical Function: Observational Study

Jeste¹,

Lee²,

Wu³

et al. 2019

JMIR Mhealth Uhealth

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Background Heart rate variability (HRV), or variation in beat-to-beat intervals of the heart, is a quantitative measure of autonomic regulation of the cardiovascular system. Low HRV derived from electrocardiogram (ECG) recordings is reported to be related to physical frailty in older adults. Recent advances in wearable technology offer opportunities to more easily integrate monitoring of HRV into regular clinical geriatric health assessments. However, signals obtained from ECG versus wearable photoplethysmography (PPG) devices are different, and a critical first step preceding their widespread use is to determine whether HRV metrics derived from PPG devices also relate to older adults’ physical function. Objective This study aimed to investigate associations between HRV measured with a wrist-worn PPG device, the Empatica E4 sensor, and validated clinical measures of both objective and self-reported physical function in a cohort of older adults living independently within a continuing care senior housing community. Our primary hypothesis was that lower HRV would be associated with lower physical function. In addition, we expected that HRV would explain a significant proportion of variance in measures of physical health status. Methods We evaluated 77 participants from an ongoing study of older adults aged between 65 and 95 years. The assessments encompassed a thorough examination of domains typically included in a geriatric health evaluation. We collected HRV data with the Empatica E4 device and examined bivariate correlations between HRV quantified with the triangular index (HRV TI) and 3 widely used and validated measures of physical functioning—the Short Physical Performance Battery (SPPB), Timed Up and Go (TUG), and Medical Outcomes Study Short Form 36 (SF-36) physical composite scores. We further investigated the additional predictive power of HRV TI on physical health status, as characterized by SF-36 physical composite scores and Cumulative Illness Rating Scale for Geriatrics (CIRS-G) scores, using generalized estimating equation regression analyses with backward elimination. Results We observed significant associations of HRV TI with SPPB (n=52; Spearman ρ=0.41; P=.003), TUG (n=51; ρ=−0.40; P=.004), SF-36 physical composite scores (n=49; ρ=0.37; P=.009), and CIRS-G scores (n=52, ρ=−0.43; P=.001). In addition, the HRV TI explained a significant proportion of variance in SF-36 physical composite scores (R2=0.28 vs 0.11 without HRV) and CIRS-G scores (R2=0.33 vs 0.17 without HRV). Conclusions The HRV TI measured with a relatively novel wrist-worn PPG device was related to both objective (SPPB and TUG) and self-reported (SF-36 physical composite) measures of physical function. In addition, the HRV TI explained additional variance in self-reported physical function and cumulative illness severity beyond traditionally measured aspects of physical health. Future steps include longitudinal tracking of changes in both HRV and physical function, which will add important insights regarding the predictive value of HRV as a biomarker of physical health in older adults.

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“…Normal aging is linked with a decline in cardiovascular control (Colosimo et al, 1997) and substantial research shows that HRV decreases with age (Agelink et al, 2001; Bonnemeier et al, 2003; O’Brien et al, 1986; Russoniello et al, 2013; Santillo et al, 2012; Schwartz et al, 1991; Wrzus et al, 2013). The age-related reduction in HRV has been observed not only in cross-sectional comparisons but also in a longitudinal study (Sinnreich et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Heart rate variability is associated with amygdala functional connectivity with MPFC across younger and older adults

et al. 2016

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The ability to regulate emotion is crucial to promote well-being. Evidence suggests that the medial prefrontal cortex (mPFC) and adjacent anterior cingulate (ACC) modulate amygdala activity during emotion regulation. Yet less is known about whether the amygdala-mPFC circuit is linked with regulation of the autonomic nervous system and whether the relationship differs across the adult lifespan. The current study tested the hypothesis that heart rate variability (HRV) reflects the strength of mPFC-amygdala interaction across younger and older adults. We recorded participants’ heart rates at baseline and examined whether baseline HRV was associated with amygdala-mPFC functional connectivity during rest. We found that higher HRV was associated with stronger functional connectivity between the amygdala and the mPFC during rest across younger and older adults. In addition to this age-invariant pattern, there was an age-related change, such that greater HRV was linked with stronger functional connectivity between amygdala and ventrolateral PFC (vlPFC) in younger than in older adults. These results are in line with past evidence that vlPFC is involved in emotion regulation especially in younger adults. Taken together, our results support the neurovisceral integration model and suggest that higher heart rate variability is associated with neural mechanisms that support successful emotional regulation across the adult lifespan.

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Electrocardiographic Analysis of Heart Rate Variability in Aging Heart

Cited by 6 publications

References 95 publications

Age‐related losses in cardiac autonomic activity during a daytime nap

Age‐related losses in cardiac autonomic activity during a daytime nap

Associations Between Heart Rate Variability Measured With a Wrist-Worn Sensor and Older Adults’ Physical Function: Observational Study

Heart rate variability is associated with amygdala functional connectivity with MPFC across younger and older adults

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