Electro-responsive polyacrylamide-grafted-gum ghatti copolymer for transdermal drug delivery application

Birajdar, Ravindra P.; Patil, Sudha B.; Alange, Vijaykumar V.; Kulkarni, Raghavendra V.

doi:10.1080/10601325.2019.1574539

Cited by 18 publications

(4 citation statements)

References 16 publications

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“…An application of a polyacrylamide-co-grafted-gum ghatti (a polysaccharide) copolymer for transdermal delivery of an antipsychotic drug (Quetiapine fumarate) triggered by electric stimulus was also explored [100].…”

Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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Synthetic polymers, biopolymers, and their nanocomposites are being studied, and some of them are already used in different medical areas. Among the synthetic ones that can be mentioned are polyolefins, fluorinated polymers, polyesters, silicones, and others. Biopolymers such as polysaccharides (chitosan, hyaluronic acid, starch, cellulose, alginates) and proteins (silk, fibroin) have also become widely used and investigated for applications in medicine. Besides synthetic polymers and biopolymers, their nanocomposites, which are hybrids formed by a macromolecular matrix and a nanofiller (mineral or organic), have attracted great attention in the last decades in medicine and in other fields due to their outstanding properties. This review covers studies done recently using the polymers, biopolymers, nanocomposites, polymer micelles, nanomicelles, polymer hydrogels, nanogels, polymersomes, and liposomes used in medicine as drugs or drug carriers for cancer therapy and underlines their responses to internal and external stimuli able to make them more active and efficient. They are able to replace conventional cancer drug carriers, with better results. Appl. Sci. 2019, 9, 3899 2 of 24 nanocomposites offer numerous opportunities in diverse applications, including nanocarriers, tissue engineering, antimicrobials, sensors, etc. These new groups of materials have gained significant research interest due to their novel properties, which are gained through the addition of nanofillers. Polymer nanocomposites have significant potential in disease theranostics, and nanotechnology brings great promise in cancer drug carriers [4].Chemotherapy implies the use of drugs and, besides the drugs, carriers. Common products used as carriers include synthetic polymers, biopolymers, and polymer nanocomposites.Some of the most useful drugs for chemotherapy are toxic chemicals able to inhibit the proliferation of cancer cells. The use of chemotherapeutic drugs has been in part hindered by their poor solubility in water, their short biological half-life, their lack of targeting ability, and the development of multidrug resistance [5]. In the last decades, nanoparticles have shown significant promise as an oncology treatment modality. Responsive polymers represent a promising class of nanoparticles that can trigger delivery through the exploitation of a specific stimuli. Response to a stimulus is one of the most basic processes found in living systems. A tutorial review highlighted the recent developments in polymer-based approaches to internally responsive nanoparticles for oncology [6].One important goal of medicine is to develop carriers that can selectively deliver anticancer drugs to tumor cells with no or minimal side effects in healthy cells [7,8].Polymers and their nanocomposites in different forms, such as micelles, hydrogels, polymersomes, and liposomes, have important potential in cancer diagnosis and treatment.Nanocomposites are popular in many areas due to properties such as their unique design capacity, eco-friendly nature, ...

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Section: Polymer Hydrogels and Nanogelsmentioning

confidence: 99%

Polymers and Polymer Nanocomposites for Cancer Therapy

Feldman

2019

Applied Sciences

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“…Raghavendra et al also prepared transdermal film using acrylamide grafted xanthan gum to deliver drug [24]. Polyacrylamide graft xanthan gum was also used for the controlled release of ketoprofen [25].…”

Section: Resultsmentioning

confidence: 99%

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

2020

Biointerface Res Appl Chem

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The present investigation is continuation of author’s previous work. In previous work, the author was prepared acrylamide grafted copolymer of neem gum and carboxymethylatedneem gum derivatives. Neem gum polysaccharide (NGP) and its derivatives viz. acrylamide grafted neem gum (NGP-g-Am) and carboxymethylated neem gum (CMNGP) were explored as film forming agent for transdermal delivery of protein/peptide drug (albumin). It was observed that films were not prepared at all the concentrations of NGP with a given concentration range. Studies show that film cannot be prepared using CMNGP even at ahigher concentration of polymer (2 % w/v solution). So only acrylamide grafted neem gum based film were prepared and evaluated. Transdermal films were prepared by using solvent casting method. The developed films were evaluated for various parameters such as drug content, folding endurance, thickness, weight variation, surface pH, moisture uptake, in vitro drug release study and ex-vivo permeation study. The films showed more than 300 folding endurance which demonstrated the good mechanical strength of film. It was also observed that after permeation studies small cracks were also formed in the films. Fabricated films were able to deliver drug upto 7 h. Drug release study and drug permeation studies showed that formulations followed zero order and KorsmeyerPepass model of kinetics. It can be concluded from the findings of the results that acrylamide graft copolymers of neem gum were able to deliver protein/peptide drugs through transdermal route.

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“…There was a 2-fold enhancement of drug flux after the application of electric stimulus than that of patches without the application of an electric stimulus. Furthermore, the drug permeation increased with the increase in electric stimulus from 2 to 8 mA (Birajdar et al, 2019).…”

Section: Gum Ghattimentioning

confidence: 95%

“…It shows excellent water solubility which is attributed to the presence of 1-6 linked glycosidic bonds (Guo et al, 2017). Birajdar et al (2019) fabricated an electric stimulusbased reservoir type of patch for quetiapine fumarate with a reservoir composed of polyacrylamide-graftedgum ghatti copolymers and a rate-controlling membrane composed of gum ghatti and PVA. There was a 2-fold enhancement of drug flux after the application of electric stimulus than that of patches without the application of an electric stimulus.…”

Section: Gum Ghattimentioning

confidence: 99%

Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature

Parhi

Sahoo

Das

2022

Braz. J. Pharm. Sci.

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The main aim of transdermal drug delivery (TDD) is to deliver a specific dose of drug across the skin and to reach systemic circulation at a controlled rate. On the other hand skin is the target for topical drug delivery. Mentioned drug delivery systems (DDS) have numerous advantages compared to oral and parenteral routes. Avoidance of first-pass metabolism, prevent drug degradation due to harsh environment of the stomach, allow controlled drug delivery, provide patient compliance, and pain-free administration are a few of them. To achieve all of them, a DDS with suitable polymer is the primary requisite. Based on the recent trends, natural polymers have been more popular in comparison to synthetic polymers because the former possesses favourable properties including nontoxic, biodegradable, biocompatible, low cost, sustainable and renewable resources. In this context polysaccharides, composed of chains of monosaccharides bound together by glycosidic bonds, have been successfully employed to augment drug delivery into and across the skin with various formulations such as gel, membrane, patches, nanoparticles, nanofibres, nanocomposite, and microneedles. In this chapter, various polysaccharides such as cellulose, chitosan, and their semisynthetic derivatives, alginate, pectin, carrageenan etc, were discussed with their diverse topical and TDD applications. In addition, various formulations based on polysaccharides and limitations of polysaccharides were also briefly discussed.

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Electro-responsive polyacrylamide-grafted-gum ghatti copolymer for transdermal drug delivery application

Cited by 18 publications

References 16 publications

Polymers and Polymer Nanocomposites for Cancer Therapy

Polymers and Polymer Nanocomposites for Cancer Therapy

Non-invasive drug delivery system for the delivery of protein/peptide using neem gum and its derivatives

Applications of polysaccharides in topical and transdermal drug delivery: A recent update of literature

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