Electrically induced arterial thrombosis model in the conscious rat

Massad, L. Stewart; Plotkine, Michel; Capdeville, C.; Boulu, R

doi:10.1016/0049-3848(87)90340-9

Cited by 23 publications

(10 citation statements)

References 28 publications

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“…Time (min) 1mA 0 Average Flow Over 100 min (%Control) Fig.4 The effect of pretreatment with WEB 2086 (PAF receptor antagonist), heparin, or PPACK (irreversible thrombin inhibitor) on arterial thrombosis was determined in anesthetized rats. Analysis (4,9). Others obtained inhibition of thrombosis with aspirin doses of -3 to 10 mg/kg, but not above 10 mg/kg (5,8).…”

Section: 60 80 100mentioning

confidence: 99%

“…We have established a high throughput model of arterial thrombosis for comparing reference and experimental antithrombotic drugs. Numerous investigators have used electrolytic injury to induce occlusive arterial thrombosis in rats (1)(2)(3)(4)(5)(6). One of these groups charact enzed these thrombi as being rich in platelets and fibrin (2,5).…”

Section: Introductionmentioning

confidence: 99%

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Effects of Antithrombotic Drugs in a Rat Model of Aspirin-Insensitive Arterial Thrombosis

et al. 1993

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SummaryThese studies describe experimental conditions where aspirin is less effective than other antiplatelet and anticoagulant drugs in inhibiting acute arterial thrombosis. External electrolytic injury of the rat carotid artery was used to induce occlusive thrombi in 97% of vehicle-treated rats. Thrombi were revealed by light and electron microscopy to be comprised primarily of platelets enmeshed in a fibrin network. The thrombin inhibitor D-phenylalanyl-L-prolyl-L-arginyl chloromethy ketone (PPACK; 6 mg/kg, i. v.) decreased thrombus weight by 90%. Aspirin alone (1, 10 and 30 mg/kg, i. v.), dipyridamole alone (5 mg/kg i. v.) and aspirin (1 and 10 mg/kg, i. v.) in combination with dipyridamole (5 mg/kg, i. v.) did not inhibit thrombosis. The platelet-activating factor (PAF) antagonist, WEB 2086, (1 mg/kg i. v.) was also ineffective. Other drugs had intermediate activity. Thrombi were decreased 56% by the thromboxane receptor antagonist, BMS 180,291, either alone (5.8 mg/kg i.v.) or in combination with aspirin (10 mg/kg, i.v.). Heparin (900 U/kg, i.v.), warfarin (0.25 mg/kg, p.o. once daily for 3 days) and ticlopidine (200 mg/ kg, p.o. once daily for 3 days) reduced thrombus weight by 63, 73 and 43% respectively. Reductions in thrombus weight were always associated with improvements in either average blood flow or vessel patency.

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Section: 60 80 100mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of Antithrombotic Drugs in a Rat Model of Aspirin-Insensitive Arterial Thrombosis

et al. 1993

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“…While aforementioned studies have led to a better understanding of the mechanical mechanism for the thrombus formation, all these studies have been conducted under the conditions that the flow is either retarded (flow stasis) (Nicolaides et al, 1972;Wessler, 1962) or disturbed (secondary flow) (Chen and Lu, 2004;Wootton and Ku, 1999), or the vessels are injured/damaged by using electrical (Massad et al, 1987;Wong et al, 2000), biochemical (Begent and Born, 1970), light-dye treatment (Sato and Ohshima, 1990;Sasaki et al, 2004;Seiffge and Kremer, 1986) or photochemical means (Rucker et al, 2002). In this project, we developed a new experimental method to test the hypothesis that thrombi can be formed in bent/stretched microvessels with normal laminar blood flow by the localized hydrodynamic stimuli.…”

Section: Introductionmentioning

confidence: 99%

Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery

Liu

Mirc

2008

Journal of Biomechanics

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“…(thromboangitis obliterans, TAO) (Buerger's disease) [1] 20-45 [2] TAO Virehow [3] [ [4][5][6] -1(intercellular cell adhesion molecule-1, Icam-1) -1 (vascular cell adhesion molecule-1, Vcam-1) (thromboxane B 2 , TXB 2 ) (antiendothelial cell antibody, AECA) TAO…”

mentioning

confidence: 99%

Establishment of thromboangitis obliterans in rats

Wang

Liu

Yang

et al. 2011

2011 International Conference on Remote Sensing, Environment and Transportation Engineering

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This project utilize surgery combine chemical method to establish rat model of thromboangitis obliterans. To appraise the model we use the method of pathology, immunology and molecular biology. The result shows that injection with laurate sodium to Femoral Artery can successfully establish rat model of thromboangitis obliterans that similar to human natural disease. Rat model pathological changes obviously, the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 mRNA rise significant in the disease region of rats, thromboxane B2 and anti-endothelial cell antibody increased significant in rats serum. These character was the same as thromboangitis obliterans in human. The rat model of thromboangitis obliterans can be used in further study, this offer a platform for the research of the pathologic mechanism and treatment of these disease. Keywords-thromboangitis obliterans; animal model; laurate sodium978-1-4244-9171-1/11/$26.00 ©2011 IEEE

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Electrically induced arterial thrombosis model in the conscious rat

Cited by 23 publications

References 28 publications

Effects of Antithrombotic Drugs in a Rat Model of Aspirin-Insensitive Arterial Thrombosis

Effects of Antithrombotic Drugs in a Rat Model of Aspirin-Insensitive Arterial Thrombosis

Mechanical mechanisms of thrombosis in intact bent microvessels of rat mesentery

Establishment of thromboangitis obliterans in rats

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