Electrical correlate of circumferential contractions in human colonic circular muscle.

Huizinga, Jan D.; Waterfall, W. E.

doi:10.1136/gut.29.1.10

“…In vitro, carbachol induces bursts of action potentials, often without any appreciable underlying depolarization (Huizinga and Waterfall, 1988). Interestingly, the development of such bursts is impaired in diverticular disease (Huizinga et al, 1999b).…”

Section: Motor Patterns Determined By Cholinergic Excitation In the Amentioning

confidence: 96%

Gastrointestinal peristalsis: Joint action of enteric nerves, smooth muscle, and interstitial cells of Cajal

Huizinga

¹

1999

Microsc. Res. Tech.

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“…The role of ICC in the pig colon has not yet been elucidated. The rat model is possibly a good model for the human colon, but evaluation of this awaits further studies into the role of ICC-AP and ICC-SMP in control of the human colon musculature (17,19).…”

mentioning

confidence: 98%

“…The role of ICC in the pig colon has not yet been elucidated. The rat model is possibly a good model for the human colon, but evaluation of this awaits further studies into the role of ICC-AP and ICC-SMP in control of the human colon musculature (17,19).One feature of streptozotocin-induced diabetes in the rat is an enlarged small intestine, which appears primarily due to an increase in mucosal mass and secondarily to an increase in muscle mass (30). Despite a 39% (30) or 76% (21) increase in small intestinal muscle mass, no changes in contractile activity in response to carbachol were observed (30), although responses to electrical stimulation of cholinergic nerves were reduced (28), possibly associated with an increase in acetylcholinesterase (21).…”

mentioning

confidence: 99%

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Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus

Forrest¹,

Huizinga²,

Wang³

et al. 2008

American Journal of Physiology-Gastrointestinal and Liver Physi

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Diabetes affects many aspects of gastrointestinal motility, in part due to changes in interstitial cells of Cajal (ICC). The effect of diabetes on the colon, however, is not well characterized, and the aim of the present study was to investigate possible relationships between altered colonic motility as a consequence of streptozotocin-induced diabetes and injury to ICC. Physiological, immunohistochemical, and ultrastructural techniques were employed. The motor pattern of the rat colon was dominated by rhythmic high-amplitude, low-frequency contractions that were primarily myogenic in origin. These rhythmic contractions were induced by stretch associated with increased tension; the amplitude of the superimposed rhythmic contractions increased with increasing applied tension. In diabetic rats, the stretch-induced rhythmic contractile activity remained robust and of similar frequency but was significantly higher in amplitude compared with that in control rats. At 700 mg of applied tension, the force of contraction in circular colonic muscle strips of the diabetic rats was 370% of control values. This robust presence of low-frequency contractions is consistent with the unaffected pacemaker, the ICC associated with Auerbach's plexus, and the increased amplitude correlates with loss of and injury to ICC of the submuscular plexus and intramuscular ICC. Loss of inhibitory nitrergic nerves does not appear to be a factor based on unaltered nNOS immunoreactivity.

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“…Reference to control activity refers to data obtained in a previous study (12). The left panel of Fig.…”

Section: Solution and Drugsmentioning

confidence: 99%

Abnormal Response to Cholinergic Stimulation in the Circular Muscle Layer of the Human Colon in Diverticular Disease

Huizinga

¹

,

Waterfall²,

Stern³

1999

Scandinavian Journal of Gastroenterology

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Electrical correlate of circumferential contractions in human colonic circular muscle.

Abstract: SUMMARY The role of myogenic electrical activity in the coordination of circumferential contraction of the human colon circular muscle was investigated. Five

Cited by 25 publications

References 17 publications

Gastrointestinal peristalsis: Joint action of enteric nerves, smooth muscle, and interstitial cells of Cajal

Gastrointestinal peristalsis: Joint action of enteric nerves, smooth muscle, and interstitial cells of Cajal

Increase in stretch-induced rhythmic motor activity in the diabetic rat colon is associated with loss of ICC of the submuscular plexus

Abnormal Response to Cholinergic Stimulation in the Circular Muscle Layer of the Human Colon in Diverticular Disease

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