Electrical bioadhesive interface for bioelectronics

Deng, Jue; Yuk, Hyunwoo; Wu, Jingjing; Varela, Claudia E.; Chen, Xiaoyu; Roche, Ellen T.; Guo, Chuan Fei; Zhao, Xuanhe

doi:10.1038/s41563-020-00814-2

Cited by 382 publications

(304 citation statements)

References 50 publications

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“…1G) and covalent crosslinking via imide bonds (Fig. 1H), respectively (20,21,25). The off-the-shelf flexible dressing form factor and the facile adhesion to wet GI tissues without the need of other devices or stimuli (e.g., UV) synergistically endow the GI patch with unique ready-to-use and preparation-free features, similar to those features of duct-tapes.…”

Section: Design and Mechanisms Of The Gi Patchmentioning

confidence: 97%

An Off-the-Shelf Bioadhesive Patch for Sutureless Repair of Gastrointestinal Defects

Yuk

Sarrafian

et al. 2021

Preprint

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Surgical sealing and repair of injured and resected gastrointestinal (GI) organs are critical requirements for successful treatment and tissue healing. Despite being the standard of care, hand- sewn closure of GI defects using sutures faces various limitations and challenges. The process remains technically complicated and time-consuming. The needle-piercing and pointwise closure also inflict tissue damage and stress concentration, raising the risk of local failure and subsequent anastomotic leaks. To address these limitations and challenges, we introduce an off-the-shelf bioadhesive GI patch capable of atraumatic, rapid, robust, and sutureless repair of GI defects. The GI patch synergistically integrates a non-adhesive top layer and a dry bioadhesive bottom layer, resulting in a thin, flexible, transparent, and ready to use dressing with tissue-matching mechanical properties. Rapid, robust, and sutureless sealing capability of the GI patch is systematically characterized based on various standard tests in ex vivo porcine GI organ models. In vitro and in vivo rat models are utilized to validate biocompatibility and biodegradability of the GI patch including comprehensive cytotoxicity, histopathology, immunofluorescence, and blood analyses. To validate the GI patch′s efficacy in a clinically relevant setting, we demonstrate successful sutureless in vivo sealing and healing of GI defects; namely in rat stomach and colon, and porcine colon injury models. The proposed GI patch not only provides a promising alternative to suture for repair of GI defects but also offers potential clinical opportunities in the treatment and repair of other organs.

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Section: Design and Mechanisms Of The Gi Patchmentioning

confidence: 97%

An Off-the-Shelf Bioadhesive Patch for Sutureless Repair of Gastrointestinal Defects

Yuk

Sarrafian

et al. 2021

Preprint

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“…[ 338 ] The integration of tough adhesives can also strengthen the electrical signal sensing stability. [ 366 ] When wireless communication technologies are integrated, the adhesive biosensors can be used for remote health monitoring with high fidelity signals.…”

Section: Future Directionsmentioning

confidence: 99%

Multifaceted Design and Emerging Applications of Tissue Adhesives

2021

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Tissue adhesives can form appreciable adhesion with tissues and have found clinical use in a variety of medical settings such as wound closure, surgical sealants, regenerative medicine, and device attachment. The advantages of tissue adhesives include ease of implementation, rapid application, mitigation of tissue damage, and compatibility with minimally invasive procedures. The field of tissue adhesives is rapidly evolving, leading to tissue adhesives with superior mechanical properties and advanced functionality. Such adhesives enable new applications ranging from mobile health to cancer treatment. To provide guidelines for the rational design of tissue adhesives, here, existing strategies for tissue adhesives are synthesized into a multifaceted design, which comprises three design elements: the tissue, the adhesive surface, and the adhesive matrix. The mechanical, chemical, and biological considerations associated with each design element are reviewed. Throughout the report, the limitations of existing tissue adhesives and immediate opportunities for improvement are discussed. The recent progress of tissue adhesives in topical and implantable applications is highlighted, and then future directions toward next‐generation tissue adhesives are outlined. The development of tissue adhesives will fuse disciplines and make broad impacts in engineering and medicine.

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“…To achieve a stable integration of bioelectronics with tissues, Zhao et al reported an e-bioadhesive interface. [145] The combination of rGO with PVA results in a graphene nanocomposite hydrogel, which can be further interpenetrated with a network of polyacrylic acids (PAAs) grafted with N-hydroxysuccinimide ester (PAA-NHS ester). This rGO-PVA-PAA-NHS ester can be dried to prepare a carboxylic acid-containing e-bioadhesive interface.…”

Section: Dchs Used As Adhesives For Bioelectronic Applicationsmentioning

confidence: 99%

Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications

Gaillez

Rothe

et al. 2021

Adv Healthcare Materials

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Conductive hydrogels (CHs) are emerging as a promising and well-utilized platform for 3D cell culture and tissue engineering to incorporate electron signals as biorelevant physical cues. In conventional covalently crosslinked conductive hydrogels, the network dynamics (e.g., stress relaxation, shear shining, and self-healing) required for complex cellular functions and many biomedical utilities (e.g., injection) cannot be easily realized. In contrast, dynamic conductive hydrogels (DCHs) are fabricated by dynamic and reversible crosslinks. By allowing for the breaking and reforming of the reversible linkages, DCHs can provide dynamic environments for cellular functions while maintaining matrix integrity. These dynamic materials can mimic some properties of native tissues, making them well-suited for several biotechnological and medical applications. An overview of the design, synthesis, and engineering of DCHs is presented in this review, focusing on the different dynamic crosslinking mechanisms of DCHs and their biomedical applications.

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Electrical bioadhesive interface for bioelectronics

Cited by 382 publications

References 50 publications

An Off-the-Shelf Bioadhesive Patch for Sutureless Repair of Gastrointestinal Defects

An Off-the-Shelf Bioadhesive Patch for Sutureless Repair of Gastrointestinal Defects

Multifaceted Design and Emerging Applications of Tissue Adhesives

Conductive Hydrogels with Dynamic Reversible Networks for Biomedical Applications

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