Electric current‐induced lymphatic activation

Kajiya, Kentaro; Matsumoto-Okazaki, Yuko; Sawane, Mika; Fukada, Kaedeko; Takasugi, Yuya; Akai, Takafumi; Saito, Naoki; Mori, Yuichiro

doi:10.1111/exd.12562

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…All methods of EStim appear to raise the intracellular calcium level to stimulate cellular proliferation [ 187 , 188 ]. However, excessive calcium can lead to cellular apoptosis [ 22 ].…”

Section: Exogenous Electric Stimulationmentioning

confidence: 99%

Bioelectricity in dental medicine: a narrative review

Min,

Gao,

Wang

2024

BioMed Eng OnLine

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Background Bioelectric signals, whether exogenous or endogenous, play crucial roles in the life processes of organisms. Recently, the significance of bioelectricity in the field of dentistry is steadily gaining greater attention. Objective This narrative review aims to comprehensively outline the theory, physiological effects, and practical applications of bioelectricity in dental medicine and to offer insights into its potential future direction. It attempts to provide dental clinicians and researchers with an electrophysiological perspective to enhance their clinical practice or fundamental research endeavors. Methods An online computer search for relevant literature was performed in PubMed, Web of Science and Cochrane Library, with the keywords “bioelectricity, endogenous electric signal, electric stimulation, dental medicine.” Results Eventually, 288 documents were included for review. The variance in ion concentration between the interior and exterior of the cell membrane, referred to as transmembrane potential, forms the fundamental basis of bioelectricity. Transmembrane potential has been established as an essential regulator of intercellular communication, mechanotransduction, migration, proliferation, and immune responses. Thus, exogenous electric stimulation can significantly alter cellular action by affecting transmembrane potential. In the field of dental medicine, electric stimulation has proven useful for assessing pulp condition, locating root apices, improving the properties of dental biomaterials, expediting orthodontic tooth movement, facilitating implant osteointegration, addressing maxillofacial malignancies, and managing neuromuscular dysfunction. Furthermore, the reprogramming of bioelectric signals holds promise as a means to guide organism development and intervene in disease processes. Besides, the development of high-throughput electrophysiological tools will be imperative for identifying ion channel targets and precisely modulating bioelectricity in the future. Conclusions Bioelectricity has found application in various concepts of dental medicine but large-scale, standardized, randomized controlled clinical trials are still necessary in the future. In addition, the precise, repeatable and predictable measurement and modulation methods of bioelectric signal patterns are essential research direction. Graphical abstract

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“…All methods of EStim appear to raise the intracellular calcium level to stimulate cellular proliferation [ 187 , 188 ]. However, excessive calcium can lead to cellular apoptosis [ 22 ].…”

Section: Exogenous Electric Stimulationmentioning

confidence: 99%

Bioelectricity in dental medicine: a narrative review

Min,

Gao,

Wang

2024

BioMed Eng OnLine

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“…Even though lymphatic drainage is not an essential factor in wound healing, lymphedema is linked to persistent wounds and inhibits wound healing [ 32 ]. In addition, via the FAK pathway, electrical stimulation has been demonstrated to promote the proliferation and migration of lymphatic endothelial cells [ 33 , 34 ].…”

Section: Electrical Stimulation Of Cellsmentioning

confidence: 99%

Effects of Electrical Stimulation of the Cell: Wound Healing, Cell Proliferation, Apoptosis, and Signal Transduction

Katoh

2023

Medical Sciences

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Electrical stimulation of the cell can have a number of different effects depending on the type of cell being stimulated. In general, electrical stimulation can cause the cell to become more active, increase its metabolism, and change its gene expression. For example, if the electrical stimulation is of low intensity and short duration, it may simply cause the cell to depolarize. However, if the electrical stimulation is of high intensity or long duration, it may cause the cell to become hyperpolarized. The electrical stimulation of cells is a process by which an electrical current is applied to cells in order to change their function or behavior. This process can be used to treat various medical conditions and has been shown to be effective in a number of studies. In this review, the effects of electrical stimulation on the cell are summarized.

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“…Kajiya et al [ 47 ] studied the behaviors of human dermal lymphatic endothelial cells (LECs) on two electrode materials. In one system, the cells were plated on a fibronectin-coated ITO electrode, with a platinum electrode placed above the cells to form capacitors.…”

Section: Electrode-based Esmentioning

confidence: 99%

Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research

2021

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Research on the cellular response to electrical stimulation (ES) and its mechanisms focusing on potential clinic applications has been quietly intensified recently. However, the unconventional nature of this methodology has fertilized a great variety of techniques that make the interpretation and comparison of experimental outcomes complicated. This work reviews more than a hundred publications identified mostly from Medline, categorizes the techniques, and comments on their merits and weaknesses. Electrode-based ES, conductive substrate-mediated ES, and noninvasive stimulation are the three principal categories used in biomedical research and clinic. ES has been found to enhance cell proliferation, growth, migration, and stem cell differentiation, showing an important potential in manipulating cellular activities in both normal and pathological conditions. However, inappropriate parameters or setup can have negative effects. The complexity of the delivered electric signals depends on how they are generated and in what form. It is also difficult to equate one set of parameters with another. Mechanistic studies are rare and badly needed. Even so, ES in combination with advanced materials and nanotechnology is developing a strong footing in biomedical research and regenerative medicine.

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Electric current‐induced lymphatic activation

Cited by 8 publications

References 9 publications

Bioelectricity in dental medicine: a narrative review

Bioelectricity in dental medicine: a narrative review

Effects of Electrical Stimulation of the Cell: Wound Healing, Cell Proliferation, Apoptosis, and Signal Transduction

Electrical Stimulation and Cellular Behaviors in Electric Field in Biomedical Research

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