Elective versus symptomatic intravenous antibiotic therapy for cystic fibrosis

Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

“…Patients in the control group were prescribed IV antibiotics three times per year while 40% of the elective treatments were in response to PEs. Thus it is unclear whether elective IV antibiotics had a significant impact on reducing the rate of PE [43] , [44] . However, the number of PEs in each group were not directly compared, thus based on the reports currently available, it is difficult to conclude whether the rate of PEs can be reduced by preventative aggressive antibiotics.…”

Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

“…Patients in the control group were prescribed IV antibiotics three times per year while 40% of the elective treatments were in response to PEs. Thus it is unclear whether elective IV antibiotics had a significant impact on reducing the rate of PE [43] , [44] . However, the number of PEs in each group were not directly compared, thus based on the reports currently available, it is difficult to conclude whether the rate of PEs can be reduced by preventative aggressive antibiotics.…”

Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use

“…First, the repeated use of antibiotics will select out resistant strains, and the practice of routine 3-monthly IV antibiotic therapy in some pediatric centers may exacerbate this. 35 Furthermore, compared with conventional ''on demand'' treatment, this practice confers no advantage in pulmonary function 36,37 and may be associated with higher mortality. 36 Indeed, many of our patients had received such prophylactic IV therapy in childhood before transfer to our unit after adolescence.…”

Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from Cystic Fibrosis patients during intravenous antibiotic treatment

“…They were treated electively with i.v. AB, according to a standard used in many European CF Centres [ 27 ] to reduce pathogen burden, inflammatory responses and pulmonary destruction. The inclusion criteria were the ability to perform NL (see below) and be CF patients receiving elective i.v.…”

Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

“…Patients in the control group were prescribed IV antibiotics three times per year while 40% of the elective treatments were in response to PEs. Thus it is unclear whether elective IV antibiotics had a significant impact on reducing the rate of PE [43] , [44] . However, the number of PEs in each group were not directly compared, thus based on the reports currently available, it is difficult to conclude whether the rate of PEs can be reduced by preventative aggressive antibiotics.…”

Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use

“…First, the repeated use of antibiotics will select out resistant strains, and the practice of routine 3-monthly IV antibiotic therapy in some pediatric centers may exacerbate this. 35 Furthermore, compared with conventional ''on demand'' treatment, this practice confers no advantage in pulmonary function 36,37 and may be associated with higher mortality. 36 Indeed, many of our patients had received such prophylactic IV therapy in childhood before transfer to our unit after adolescence.…”

Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from Cystic Fibrosis patients during intravenous antibiotic treatment

“…They were treated electively with i.v. AB, according to a standard used in many European CF Centres [ 27 ] to reduce pathogen burden, inflammatory responses and pulmonary destruction. The inclusion criteria were the ability to perform NL (see below) and be CF patients receiving elective i.v.…”

Candidate Markers Associated with the Probability of Future Pulmonary Exacerbations in Cystic Fibrosis Patients

“…Patients in the control group were prescribed IV antibiotics three times per year while 40% of the elective treatments were in response to PEs. Thus it is unclear whether elective IV antibiotics had a significant impact on reducing the rate of PE [43] , [44] . However, the number of PEs in each group were not directly compared, thus based on the reports currently available, it is difficult to conclude whether the rate of PEs can be reduced by preventative aggressive antibiotics.…”

Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use

“…First, the repeated use of antibiotics will select out resistant strains, and the practice of routine 3-monthly IV antibiotic therapy in some pediatric centers may exacerbate this. 35 Furthermore, compared with conventional ''on demand'' treatment, this practice confers no advantage in pulmonary function 36,37 and may be associated with higher mortality. 36 Indeed, many of our patients had received such prophylactic IV therapy in childhood before transfer to our unit after adolescence.…”

Dynamics of soluble and cellular inflammatory markers in nasal lavage obtained from Cystic Fibrosis patients during intravenous antibiotic treatment

“…They were treated electively with i.v. AB, according to a standard used in many European CF Centres [ 27 ] to reduce pathogen burden, inflammatory responses and pulmonary destruction. The inclusion criteria were the ability to perform NL (see below) and be CF patients receiving elective i.v.…”