INTRODUCTIONDrugs therapy in elderly is challenging, because of pharmacokinetic changes of ageing which often results in drug-drug interactions leading to disproportionately high rate of ADRs. ADRs are responsible for 3%-13% of all the admissions and complicate 5%-20% of hospital stay in patients aged more than 65 years.1 Age-related polypathology often demands multiple medications giving rise to polypharmacy among elderly. Polypharmacy increases the risk of drug-related events such as falls, confusion and functional decline in elderly. Polypharmacy, in-turn increases the risks of negative health outcomes like drug interactions, ADRs, hospital admission leading to economic burden. Previous studies have reported depression, cumulative co-morbidity; inappropriate prescribing practice and selected chronic conditions like diabetes mellitus and congestive heart failure as the Positive correlates of polypharmacy.2 The other factors negatively influence polypharmacy were identified to be smoking, alcohol consumption, cognitive ability, physical status and ADRs before admission.
3Identifying the predictors of polypharmacy in elderly will help to frame interventional strategies to rationalize the prescribing practices.Psychological well-being is considered as one of the important index of successful aging. Elderly population often succumbs to depression because of multiple medical ailments or individual's self-perceived health. 4 The association of depression and polypharmacy appears to be bidirectional. Depression was found to be a main ABSTRACT Background: Polypharmacy is a reliable indicator of irrational prescribing particularly among elderly. Polypharmacy increases the risk of adverse drug reactions (ADRs) exponentially imposing higher economic burden. Addressing and evaluating the prescribing practices in elderly will rationalize the drug utilization leading to improvement in quality of health care. The present study was taken to evaluate the determinants of polypharmacy and its association with depression, defined as a 15 item geriatric depression scale (GDS) >6, in elderly patients. Methods: This prospective cohort study was conducted at department of medicine, Victoria hospital, Bengaluru 100 patients aged 60 and above years was enrolled. Relevant data regarding patients' demographic details, smoking and alcohol consumption, medical diagnosis and drug details were collected. Geriatric Depression Scale was used to diagnose depression. Results: Out of 100 patients screened, 36% were males and 64% were females. Polypharmacy was noted in 73% of the elderly, of which 43% had cumulative co morbidity (≥4 diagnoses). 68% were found to have a GDS score of ≥6, which corresponded to Depression. Patients with depression (GDS score ≥6) had 1.54 (OR-1.54, 95% CI-0.59-4.01) times more risk of encountering polypharmacy (≥4 drugs). Cumulative co-morbidity (OR-1.52, 95% CI-1.08-2.11, p <0.05) was identified as an independent correlate of polypharmacy. Conclusions: Increasing age, males, Cumulative comorbidity of ≥4 diagnoses and ...