Elastolytic cutaneous lesions in myeloma-associated amyloidosis

Yoneda, K.

doi:10.1001/archderm.126.5.657

Cited by 14 publications

(25 citation statements)

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“…Alternatively, fragmentation and loss of elastic fibres was reported in a patient affected by systemic LCDD with unusual lung involvement [21]. In the same way, the current authors found reports of three patients with multiple myeloma complicated by skin lesion combining light chain amyloidosis and elastolysis [22,23]. In the present study, ECM investigation in CL-LCDD showed a widespread and quite complete degradation of the elastic network involving alveoli, small airways and vessels.…”

Section: Discussionsupporting

confidence: 80%

Pathomechanisms of cyst formation in pulmonary light chain deposition disease

Colombat¹,

Caudroy²,

Lagonotte³

et al. 2008

European Respiratory Journal

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Cystic lung light chain deposition disease (CL-LCDD) is a recently described rare disorder characterised by numerous cysts and diffuse monoclonal nonamyloid light chain deposits surrounded by macrophagic giant cells. The mechanisms responsible for cyst development remain unknown.The objectives of the present study were to analyse the major components of the pulmonary extracellular matrix in CL-LCDD and to determine the influence of metalloproteinases (MMPs) by comparison with other cystic lung disorders.A virtually complete degradation of the elastic network was found in CL-LCDD. To a lesser degree, loss of fibrillar and basement membrane collagens was also observed. Macrophagic giant cells expressed MMP-1, MMP-2, MMP-9, MMP-12 and MMP-14 and in situ zymography highlighted a strong gelatinolytic activity. As in CL-LCDD, cystic lesions in Langerhans' cell histiocytosis (LCH) and lymphangioleiomyomatosis (LAM) were characterised by the lack of elastic fibres. Similarly, MMP were expressed in CL-LCDD and LCH but the labelled cells were different. In contrast, few MMPs were detected in LAM.In conclusion, elastolysis is common to cystic lung light chain deposition disease and other cystic lung disorders, suggesting its implication in cyst formation. Moreover, in cystic lung light chain deposition disease, a role of metalloproteinases in elastolysis is strongly indicated by the metalloproteinase expression and activity pattern.

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Section: Discussionsupporting

confidence: 80%

Pathomechanisms of cyst formation in pulmonary light chain deposition disease

Colombat¹,

Caudroy²,

Lagonotte³

et al. 2008

European Respiratory Journal

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“…Nevertheless, many other cutaneous clinical manifestations have been reported. Among them, alopecia, 109-111 cutis laxa, [112][113][114][115] or bullae. [116][117][118][119][120][121][122][123][124] Blisters are also frequent due to cleavage developing within the amyloid deposits and many times are hemorrhagic and occur on the tongue or bucal mucosa (Fig.…”

Section: Changes In the Skin In Systemic Amyloidosismentioning

confidence: 99%

Cutaneous Amyloidosis: A Concept Review

Fernández-Flores

2012

The American Journal of Dermatopathology

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Concepts and semantics are crucial for good communication between clinicians and pathologists. Amyloidosis was described more than 150 years ago. Therefore, the terminology related to it is abundant, varied, and sometimes complex. In this report, we intend to discuss several terms related to the disease, with special emphasis on cutaneous amyloidosis. We present a review, from Virchow to present, of the concepts related to amyloidosis: its nature, the classification of cutaneous forms of the disease, and the techniques used in its diagnosis.

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“…It may be generalized or localized. Most of the cases reported in the literature refer to the generalized form (type I) which usually develop after inflammatory episodes, hypersensitivity reactions, neoplastic and hematologic disorders or in association with particular diseases [5][6][7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…In review of the literature, few cases of localized acquired cutis laxa are described, but in the large majority the development of clinical manifestations was preceded by inflammatory lesions [5][6][7][8][9]. No medical treatment is available for correction of the pathology of disease or to reduce its progression.…”

Section: Discussionmentioning

confidence: 99%