Elastic fiber pattern in regressing melanoma: a histochemical and immunohistochemical study

Kamino, Hideko; Tam, Sam; Roses, Daniel F.; Toussaint, Sonia

doi:10.1111/j.1600-0560.2010.01531.x

Cited by 21 publications

(29 citation statements)

References 24 publications

(37 reference statements)

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“…The pattern of elastic fibers in melanoma with regression is different from the melanomas with scar after a surgical procedure. The newly formed scar shows absence of elastic fibers in contrast to the “crushing” pattern in under regressing melanoma …”

Section: Use Of Evg Staining In Neoplasmsmentioning

confidence: 94%

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

et al. 2012

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Elastic fibers are important components of the skin and are responsible for skin elasticity. Genetic defects are well-known in numerous hereditary elastic tissue disorders and skin biopsies are often the first step in the evaluation of those disorders. Verhoeff-Van Gieson elastic staining is a simple method that is used for visualizing elastic fibers. With the development of modern immunohistochemical methods, the value of routine histochemical staining is sometimes underestimated. Histochemical stains are less expensive, easy to perform and help to resolve numerous diagnostic quandaries in dermatopathology. This article focuses on the value of elastic tissue staining in dermatopathology, with a focus on primary elastic tissue disorders, alopecia, inflammatory skin disorders and neoplastic proliferations. Connective tissue comprises of three types of fibers: collagen fibers, reticular fibers and elastic fibers. These fibers are made of proteins and composed of long peptide chains. While the main function of collagen and reticular fibers is to provide tensile strength and support respectively, the elastic fibers are mainly there for providing stretchability and flexibility. Elastic fibers can stretch up to 1.5 times their length, and snap back to their original length when relaxed. The long and branching arrangement of fibers enables them to stretch and recoil thus providing flexibility to tissues. Elastic fibers are composed of two structural components: elastin and microfibrils, and include elastin, elaunin and oxytalan.

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Section: Use Of Evg Staining In Neoplasmsmentioning

confidence: 94%

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

et al. 2012

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“…The elastic fibers in between melanoma cells are often lysed, while those between the cells of a nevus are preserved (Kamino et al 2010). The elastic fibers in between the cells of a congenital nevus can have an exaggerated pattern, which is particularly helpful when contrasting them with the absence of fibers in between the cells of small cell melanomas.…”

Section: Differential Diagnosismentioning

confidence: 99%

Melanoma Arising in a Pre-Existent Nevus

Massi

LeBoit

2013

Histological Diagnosis of Nevi and Melanoma

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“…In contrast, the base of scars lack that compressed elastic layer. 145,146 Differentiation of Spitz nevus from spitzoid melanoma can be problematic, as exemplified by the number of cases sent for consultation. In addition, lesions are often only partially sampled, further complicating diagnosis.…”

Section: Benign Versus Malignantmentioning

confidence: 99%

Immunohistochemistry in Dermatopathology

Ferringer

2015

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Immunohistochemistry is not a diagnostic test but a highly valuable tool that requires interpretation within a context.Objective.-To review the current status and limitations of immunohistochemistry in dermatopathology.Data Sources.-English-language literature published between 1980 and 2014.Conclusions.-Although immunohistochemistry is rarely completely specific or sensitive, it is an important adjunctive technique in dermatopathology and can be helpful in a series of diagnostic dilemmas.

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Elastic fiber pattern in regressing melanoma: a histochemical and immunohistochemical study

Abstract: We have identified distinct changes of the elastic tissue network, which more accurately define the presence of regression in melanoma and distinguish it from scarring fibrosis.

Cited by 21 publications

References 24 publications

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

The utility of elastic Verhoeff‐Van Gieson staining in dermatopathology

Melanoma Arising in a Pre-Existent Nevus

Immunohistochemistry in Dermatopathology

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