Elastic, Conductive, Polymeric Hydrogels and Sponges

Lu, Yun; He, Wenming; Cao, T.Q.; Guo, Haitao; Zhang, Yongyi; Li, Qingwen; Shao, Ziqiang; Cui, Yulin; Zhang, Xuetong

doi:10.1038/srep05792

Cited by 150 publications

(107 citation statements)

References 50 publications

(58 reference statements)

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“…However, conductive biomaterials for ECPs have proven to attain a better performance for the functionalization of cardiomyocytes, including for the maturation of the myocardium and for synchronous contraction. [13,[37][38][39] The synchronous contraction ability is mainly based on the expression of cardiac-specific proteins. One such specific cardiac markers is α-actinin, which has been connected to the maturation of the myocardium and regulation of muscle contractions.…”

Section: Effect Of Incorporated Ppy On In Vitro Functionalization Of mentioning

confidence: 99%

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Wang

Jiang

Hua

et al. 2016

Adv Funct Materials

157

130

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The engineered cardiac patch (ECP) is a promising strategy to repair infarct myocardium and restore the cardiac function. An ideal ECP should be able to mimic the primary attributes of native myocardium, which includes a high resilience, good cardiomyocyte adhesion, and synchronous contraction. Here, a mussel‐inspired dopamine crosslinker is used to integrate polypyrrole (Ppy) nanoparticles, gelatin‐methyacrylate, and poly(ethylene glycol) diacrylate into a cryogel form. The dopamine crosslinker and Ppy nanoparticles are coordinated to obtain optimal mechanical and superelastic properties for the ECP. The dopamine facilitates the uniform distribution of the Ppy nanoparticles, which migrate and fuse from the scaffold to the surface of the cardiomyocytes, revealing a potential mechanism for restoring infarct myocardium. The incorporated Ppy nanoparticles thus significantly enhance the functionalization of the cardiomyocytes, resulting in excellent synchronous contraction by increasing the expression of α‐actinin and CX‐43. Cardiomyocytes‐loaded ECP can improve the cardiac function in myocardial‐infarction (MI) affected rat models. The results show that the fractional shortening and ejection fraction are elevated by about 50% and that the infarct size is reduced by 42.6%. Collectively, this study highlights an effective cardiac patch based on mussel‐inspired conductive particle adhesion and a superelastic cryogel promising for the restoration of infarcted myocardium.

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Section: Effect Of Incorporated Ppy On In Vitro Functionalization Of mentioning

confidence: 99%

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Wang

Jiang

Hua

et al. 2016

Adv Funct Materials

157

130

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“…concentrated polyaniline (PANI) solutions tend to gelatinize with time. Since then, the preparation of conducting polymer hydrogels has been intensively investigated in the past decade, involving cross-linking with chemical bonds or physical nodes (crystallites or aggregates) [27][28][29][30][31]. Besides, conducting polymer hydrogels can also be prepared by incorporating of conducting polymers with the host hydrogel matrix [32,33].…”

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confidence: 99%

Conducting polymer hydrogel materials for high-performance flexible solid-state supercapacitors

et al. 2016

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Different from solid electrodes, conducting polymer hydrogel electrodes swollen with water and ions, can reach contact with the electrolyte solution at the molecular level, which will result in more efficient electrochemical process of supercapacitors. Besides, the inherent soft nature of hydrogel material offers the electrode superior flexibility, which benefits to gain high flexibility for devices. Here, this perspective briefly introduces the current research progress in the field of conducting polymer hydrogel electrodes-based flexible solid-state supercapacitor and gives an outlook on the future trend of research.Keywords: Conducting polymer hydrogels, flexible supercapacitor, soft electrode, polyaniline, integrated device Nowadays, flexible energy storage devices (batteries and supercapacitors) have received widely attentions as the rapid progress of flexible and wearable electronics [1,2]. Flexible solid-state supercapacitors represent a new type of supercapacitor that can work under consecutive bending, stretching and even twisting states [3][4][5]. However, it remains a large challenge to obtain a flexible solid-state supercapacitor with high electrochemical performance and superior flexibility. The performance of a flexible supercapacitor mainly depends on the properties of electrode materials and the device configuration [6]. The electrode materials of supercapacitor include various nanocarbons, conducting polymers and transition metal oxides [7][8][9][10][11][12]. Conducting polymer electrodes possess several merits, such as high electric conductivity, large capacitance, inherent flexibility and easy to processing [13][14][15][16][17][18]. However, the separations of the molecular chains in conducting polymers are generally small relative to the double layer thickness, which results in low capacitance [19]. Besides, the low ionic mobility in the polymer matrix reduces the maximum power density of such electrodes [20].On the other hand, the current device configuration of the flexible solid-state supercapacitor somewhat hinders the device to gain better performance. Generally, a flexible solid-state supercapacitor consists of a "sandwich" laminated structure, including two flexible solid electrodes and the middle gel polymer electrolyte layer [21]. In terms of this structure, the solid electrode materials hardly make a sufficient contact with the gel polymer electrolyte that possesses large viscosity and poor diffusion, which results in low capacitance and sluggish the electrochemical response.Hydrogel is made up of solid three-dimensional polymeric networks and large amounts of water medium [22]. Generally, the hydrogels are employed as solid-state electrolyte of supercapacitors, such as polyvinyl alcohol (PVA) gel polymer electrolyte. Recently, conducting polymer hydrogels were used as electrode materials for supercapacitors instead of traditional solid electrodes [19,[23][24][25]. This "aqua material electrode" is conducting polymer matrix swollen with water and ions, which hence produce a...

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“…Conducting polymer hydrogels (CPHs) are another unique types of hydrogels that are employed chemical industries, implants of electrochemical biosensors, and for electro-stimulated drug release [172]. CPHs have the ability as conductive flexible electrodes for supercapacitor purpose [173], also it is used in bioelectronics, server as energy storage devices and biosensors of glucose enzymes with high sensitivity [174].…”

Section: Hydrogels For Pharmaceutical Applicationsmentioning

confidence: 99%

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

Raza

Zafar

Zhu

et al. 2017

Preprint

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Hydrogels evolved as an outstanding carrier material for local and controlled drug delivery that tend to the shortcomings of old conventional dosage forms for small drugs (NSAIDS) and large peptides and proteins. Aqueous swellable and crosslinked polymeric network structure of hydrogels is composed of various natural, synthetic and semisynthetic biodegradable polymers. Hydrogels have remarkable properties of functionality, reversibility, sterilizability, and biocompatibility. All these dynamic properties of hydrogels have increased the interest in their use as a carrier for peptides and proteins to be released slowly in a sustained manner. The therapeutical peptide and proteins are remarkable therapeutic agents in today's world that allows the treatment of severe, chronic and life-threatening diseases, such as diabetes, rheumatoid arthritis, hepatitis in an easy manner. Despite few limitations, hydrogels provide fine tuning of proteins and peptides delivery with enormous impact in clinical medicine. The primary objective of this article is to review current issues concerned with the therapeutics peptides and proteins and impact of remarkable properties of hydrogels on these therapeutic agents. Different routes for pharmaceutical peptides and proteins and superiority over other drugs candidates are presented. The article will also review literature concerning classification of hydrogels on different basis, polymers used, release mechanisms their physical and chemical characteristics and diverse applications.

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Elastic, Conductive, Polymeric Hydrogels and Sponges

Cited by 150 publications

References 50 publications

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Mussel‐Inspired Conductive Cryogel as Cardiac Tissue Patch to Repair Myocardial Infarction by Migration of Conductive Nanoparticles

Conducting polymer hydrogel materials for high-performance flexible solid-state supercapacitors

A Review on Recent Advances in Stabilizing Peptides/Proteins upon Fabrication in Hydrogels from Biodegradable Polymers

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