Ejaculation Disorders in Male Patients with Cancer: A Systematic Review and Meta-Analysis of Prevalence

Pizzol, Damiano; Trott, Mike; Grabovac, Igor; Yang, Lin; Barnett, Yvonne; Parris, Christopher N.; McDermott, Daragh T.; Veronese, Nicola; Kronbichler, Andreas; Ghayda, Ramy Abou; Soysal, Pınar; Jacob, Louis; Tully, Mark A.; Koyanagi, Ai; Law, Christopher Tejun; Kaya, Çoşkun; Thirumavalavan, Nannan; Loeb, Aram; Garolla, Andrea; Park, Seoyeon; Smıth, Lee; Ilie, Petre Cristian; Smith, Lee

doi:10.1097/ju.0000000000002136

Cited by 5 publications

(5 citation statements)

References 27 publications

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“…In our study age was confirmed to be an independent predictor of sampling. Several analyses showed a high prevalence of ejaculatory dysfunction among patients with cancer and cancer survivors [23]. In our series, we found that 60% of men who had accepted to participate and were not able to collect their SF reported a psychogenic inhibition; all our patients had received a diagnosis of PCa.…”

Section: Discussionmentioning

confidence: 50%

Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer

Saitta

Simone

Fasulo

et al. 2023

Cancers

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Liquid biopsy (LB) for prostate cancer (PCa) detection could represent an alternative to biopsy. Seminal fluid (SF) is a source of PCa-specific biomarkers, as 40% of ejaculate derives from the prostate. We tested the feasibility of an SF-based LB by evaluating the yield of semen self-sampling in a cohort of >750 patients with clinically localized PCa. The overall SF collection yield was 18.2% (39% when considering only compliant patients), with about a half of the patients (53.15%) not consenting to SF donation. Independent favorable predictors for SF collection were younger age and lower prostate volume. We implemented a protocol to enrich prostate-derived cells by multi-color flow cytometry and applied it on SF and urine samples from 100 patients. The number of prostate-enriched cells (SYTO-16+ PSMA+ CD45−) was variable, with higher numbers of cells isolated from SF than urine (p value < 0.001). Putative cancer cells (EpCAMhigh) were 2% of isolated cells in both specimens. The fraction of EpCAMhigh cells over prostate-enriched cells (PSMA+) significantly correlated with patient age in both semen and urine, but not with other clinical parameters, such as Gleason Score, ISUP, or TNM stage. Hence, enumeration of prostate-derived cells is not sufficient to guide PCa diagnosis; additional molecular analyses to detect patient-specific cancer lesions will be needed.

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Section: Discussionmentioning

confidence: 50%

Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer

Saitta

Simone

Fasulo

et al. 2023

Cancers

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“…Particularly, although our review identified two maternal-paternal outcomes (need for fertility treatment and birth rate), we did not identify any studies that specifically evaluated the impact of male AYA cancer on paternal reproductive health outcomes. A 2021 systematic review and meta-analysis by Pizzol et al summarized the impact of cancer treatment on ejaculatory dysfunction across all males with cancer in cross-sectional and case-control studies [ 47 ]. This review established that cancer treatment involving the lower spinal cord can impact ejaculatory function (prevalence of 6.8 to 68.7%).…”

Section: Discussionmentioning

confidence: 99%

Reproductive Health Outcomes among Adolescent and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Oveisi

Cheng

Ellis

et al. 2023

Cancers

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Background: This systematic review and meta-analysis (SRMA) aimed to synthesize the current literature on the impacts of adolescent and young adult (AYA, ages 15–39 years) cancer on reproductive health outcomes. Methods: EMBASE and Medline were searched from 1 January 2000 to 26 January 2022 for observational studies that included individuals with AYA cancer and controls which evaluated reproductive health outcomes. We used random effects models and 95% confidence intervals to obtain pooled measures of associations between AYA cancer, cancer treatment, and reproductive health outcomes. Results: The search identified 8625 articles; 21 were included. 62 reproductive outcomes were assessed and classified according to a sex-based framework as fetal/neonatal (n = 26), maternal (n = 11), fetal/neonatal-maternal (n = 23), and maternal-paternal (n = 2). Meta-analyses of crude estimates showed significant associations between AYA cancer and outcomes including preterm birth (pooled odds ratio [pOR] 1.31; 95% CI: 1.22, 1.42), gestational diabetes (pOR 1.43; 95% CI: 1.03, 1.99), and fertility treatment (pOR 2.66; 95% CI 1.71, 4.11). We also found higher odds of preterm birth (pOR 1.65; 95% CI: 1.21, 2.26) and low APGAR score at birth (pOR 2.03; 95% CI: 1.32, 3.13) among AYA cancer patients who received radiation compared to controls. Conclusions: Our SRMA quantified impacts of AYA cancers and treatments on several reproductive health outcomes.

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“…B. Pizzol et al 2021 ; Santos Gonçalves et al 2022 ), könnte aber durch differenziertere statistische Analysen ergänzt werden. Weiterhin ist zu konstatieren, dass die bisherige Literatur zur Orgasmus-Lücke sich auf cis-geschlechtliche Frauen beschränkt und Aussagen über trans Frauen somit (noch) nicht möglich sind ( Hamm und Nieder 2021 ).…”

Section: Diskussionunclassified

Der Gender Orgasm Gap. Ein kritischer Forschungsüberblick zu Geschlechterdifferenzen in der Orgasmus-Häufigkeit beim Heterosex

Döring

Mohseni

2022

Z Sex Forsch

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Zusammenfassung Einleitung Seit den 1960er-Jahren wird in Wissenschaft, Frauenbewegung und breiter Öffentlichkeit darüber diskutiert, dass und warum Frauen beim Heterosex seltener Orgasmen erleben als Männer und ob und wie man diesen Gender Orgasm Gap schließen kann. Im Rahmen eines bio-psycho-sozialen Verständnisses von Sexualität werden Gender Orgasm Gaps theoretisch sehr unterschiedlich erklärt. Forschungsziele Ziel des vorliegenden Forschungsüberblicks ist es, die bisherigen empirischen Befunde zur Größe des Gender Orgasm Gap zu berichten sowie die vorgeschlagenen Praxismaßnahmen zu seiner Überwindung zu präsentieren und kritisch zu diskutieren. Methoden Im Zuge einer systematischen Literaturrecherche wurden n = 20 empirische Publikationen zum Gender Orgasm Gap und zusätzlich n = 16 wissenschaftliche Originalarbeiten zu seinem Abbau identifiziert und kodiert (1982–2021). Ergebnisse Die eingeschlossenen Umfragen basieren auf Angaben von N = 49 940 Frauen und N = 48 329 Männern und zeigen, dass typischerweise 30 % bis 60 % der befragten Frauen berichten, beim Heterosex zum Orgasmus zu kommen, im Unterschied zu 70 % bis 100 % der Männer. Je nach Rahmenbedingungen des Heterosex schwankt die Größe des Gender Orgasm Gap zwischen –20 % und –72 % zuungunsten der Frauen. Die vorliegenden zehn bevölkerungsrepräsentativen Umfragen ergeben einen gewichteten mittleren Gender Orgasm Gap von –30 % [95 %iges Konfidenzintervall: –31 %; –30 %]. Die in der bisherigen Fachliteratur vorgeschlagenen Maßnahmen zum Schließen dieser Orgasmus-Lücke beziehen sich auf personale Faktoren, Beziehungsfaktoren, sexuelle Interaktionsfaktoren und gesellschaftliche Faktoren: Frauen wird empfohlen, den eigenen Orgasmus bewusster anzustreben und in der Beziehung offener über sexuelle Wünsche zu sprechen. Zudem wird Frauen und Männern geraten, mehr direkte klitorale Stimulation in den Heterosex zu integrieren und Orgasmen von Frauen gesellschaftlich zu demarginalisieren. Schlussfolgerung Aus dem bisherigen Forschungsstand leitet sich die Notwendigkeit ab, Fragen rund um den Gender Orgasm Gap weiterhin in Wissenschaft und Praxis zu bearbeiten. Angesichts der begrenzten Erfolge der letzten Dekaden scheint es jedoch auch geboten, die bisher verfolgten Ansätze im „Kampf um Orgasmus-Gerechtigkeit“ kritisch zu hinterfragen.

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Ejaculation Disorders in Male Patients with Cancer: A Systematic Review and Meta-Analysis of Prevalence

Cited by 5 publications

References 27 publications

Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer

Evaluation of Semen Self-Sampling Yield Predictors and CTC Isolation by Multi-Color Flow Cytometry for Liquid Biopsy of Localized Prostate Cancer

Reproductive Health Outcomes among Adolescent and Young Adult Cancer Patients: A Systematic Review and Meta-Analysis

Der Gender Orgasm Gap. Ein kritischer Forschungsüberblick zu Geschlechterdifferenzen in der Orgasmus-Häufigkeit beim Heterosex

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